Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
IDX375 is a selective non-nucleoside inhibitor targeting the Hepatitis C Virus (HCV) NS5B polymerase. This compound exhibits potent inhibitory activity primarily against HCV genotypes 1a and 1b. The binding interactions and structural conformation of IDX375 have been validated through X-ray co-crystallization studies, providing insight into its mechanism of action. This reagent is useful for research applications focusing on HCV replication and therapeutic development. -
Endogenous Metabolite
Dihydro FF-MAS is a steroid triterpenoid that serves as an important intermediate in the cholesterol synthesis pathway. This compound has been shown to induce the resumption of meiosis in cultured mouse oocytes in vitro, making it a valuable tool for studying reproductive processes. Additionally, Dihydro FF-MAS can be utilized in research focused on lipid metabolism, offering insights into cellular and physiological mechanisms related to these biological systems. -
Fungal Metabolite
Acremine F is a fungal metabolite derived from the genus Acremonium, known for its antimicrobial properties. This compound exhibits significant activity against various fungal strains, making it a valuable tool for antifungal research and development. Its unique bioactivity profile supports studies in mycology and the exploration of potential therapeutic applications in treating fungal infections. -
Endogenous Metabolite
Conglobatin C1 is an endogenous bacterial metabolite that exhibits notable anticancer activity. It demonstrates cytotoxic effects against NS-1 mouse myeloma cells, with an IC50 of 1.05 μg/mL. This compound is valuable for research applications aimed at understanding cancer cell biology and exploring potential therapeutic strategies in oncology. -
Endogenous Metabolite
Guanosine triphosphate tritris (GTP tritris) is an essential endogenous metabolite involved in myogenic cell differentiation and modulation of miRNA-myogenic regulator factors. It facilitates the export of exosomes rich in guanosine and is a key activated precursor for RNA synthesis. GTP tritris is crucial for mitochondrial function, aiding in protein import into the matrix, initiating peptide synthesis, and driving polypeptide chain elongation. Furthermore, it serves as a phosphate and pyrophosphate carrier, activating signal transducing G proteins that influence cellular processes such as proliferation and apoptosis, while participating in vesicle docking and fusion through interactions with small GTPases. -
Endogenous Metabolite
Stercobilinogen is an endogenous metabolite derived from the bacterial metabolism of bilirubin. It serves as a significant biomarker in the study of gut microbiota and its influence on bilirubin metabolism. This compound is instrumental in metabolic research and contributes to the understanding of gastrointestinal health and liver function. -
Endogenous Metabolite
1,2-Dinervonoyl-sn-glycero-3-phosphocholine is an endogenous metabolite characterized by its two 24-carbon fatty acid chains, each containing a cis double bond at the 15th carbon. This phospholipid is believed to play a significant role in neuronal differentiation signaling and modulates various cellular processes in the nervous system. It serves as a valuable reagent for research aimed at elucidating the mechanisms of neurodevelopment and synaptic function. -
Endogenous Metabolite
1,6-Dimethylnaphthalene is an organic compound primarily recognized for its role as an endogenous metabolite. This compound exhibits flavoring and synergistic properties, making it valuable in various chemical synthesis applications. Additionally, 1,6-Dimethylnaphthalene serves as a catalyst in select reactions, contributing to compound development and environmental science research. Its unique characteristics make it suitable for the production of high-performance materials. -
Endogenous Metabolite
3-(Oleoyloxy)propane-1,2-diyl distearate targets endogenous metabolites and is classified as a triacylglycerol. This compound features stearic acid moieties at the sn-1 and sn-2 positions, with an oleic acid residue at the sn-3 position. It is naturally occurring in cocoa butter and various vegetable oils, making it relevant for studies on lipid metabolism and dietary fats. -
Pheromone
(7Z)-7-Tricosene is a naturally occurring pheromone primarily known for its role in insect communication, particularly produced by Aleochar curtula. This compound exhibits key biological activity by influencing mating behaviors and social interactions among certain insect species. It is valuable for research applications in entomology, behavioral ecology, and the study of chemical signaling in insects. -
Endogenous Metabolite
ATP magnesium is an essential endogenous metabolite involved in energy storage and metabolism. It provides the necessary metabolic energy for various cellular processes and acts as a coenzyme in biochemical reactions. Additionally, ATP magnesium plays a critical role as a signaling molecule in immune responses and inflammatory processes, making it valuable for research into cellular signaling and metabolic pathways. -
Endogenous Metabolite
Pirbuterol dihydrochloride is a beta-2 adrenergic agonist that acts primarily as a bronchodilator. It exhibits comparable duration of action to albuterol when administered via inhalation, making it a useful agent for respiratory conditions. With similar beta-2 selectivity to albuterol in human studies, Pirbuterol dihydrochloride is valuable in research focused on airway responsiveness and therapeutic interventions for asthma or chronic obstructive pulmonary disease (COPD). -
Endogenous Metabolite
Ribulose 1,5-bisphosphate (RuBP) is a crucial photosynthetic intermediate that serves as a substrate for carbon fixation. It plays a pivotal role in catalyzing the carboxylation reaction and is essential for the regeneration phase of the Calvin cycle. RuBP binds tightly to inactive RuBP carboxylase, influencing photosynthetic efficiency and control dynamics. This compound is widely utilized in research focused on photosynthesis mechanisms and enzyme dynamics related to carbon fixation processes. -
Endogenous Metabolite
Docosapentaenoylcarnitine (C22:5n3) is an endogenous metabolite that plays a role in metabolic processes. This compound is involved in the regulation of fatty acid metabolism and has been implicated in various physiological pathways. Its unique structure allows it to participate in research applications related to lipid metabolism and energy homeostasis. -
Endogenous Metabolite
CHET3 is an endogenous metabolite that acts as a selective activator of TASK-3-containing K2P channels. It demonstrates significant analgesic activity, effectively modulating the membrane excitability of specific small sensory neurons. Research applications include studying acute and chronic pain models in mice, where CHET3's effects on thermal hypersensitivity and mechanical hyperalgesia can be thoroughly examined. The analgesic effects of CHET3 are sensitive to pharmacological inhibition and genetic knockout of TASK-3, highlighting its precise mechanism of action. -
Endogenous MetaboliteModulator
10(S),17(S)-DiHDHA is a dihydroxy fatty acid derived from docosahexaenoic acid (DHA) that serves as a modulator of endogenous metabolites. This compound demonstrates significant neuroprotective and anti-inflammatory properties, making it valuable for research in neurobiology and inflammation. It is commonly used in studies focusing on neuronal preservation and the regulation of inflammatory responses. -
Endogenous Metabolite
Pyrocatechol sulfate is an endogenous phenolic metabolite linked to dietary intake, particularly from foods such as berries, and may reflect gut microbiota status. It is a promising urinary biomarker for assessing kidney function, dialytic clearance, whole grain consumption, and regular coffee intake. Furthermore, Pyrocatechol sulfate contributes to the modulation of various biological activities, including neuroprotection and the regulation of cardiomyocyte rhythmicity, making it valuable for studies in nutrition, metabolism, and cardiovascular health. -
PROTOX Inhibitor
Acifluorfen sodium is a protoporphyrinogen oxidase (PROTOX) inhibitor that leads to the accumulation of protoporphyrin IX (PPIX). This compound is primarily utilized in agricultural research as a herbicide, where it demonstrates the capacity to induce oxidative damage in target plant species by promoting photooxidative degradation of pigments and lipids. Additionally, its effects on liver tumor induction in rodent models make it a valuable tool for studying tumorigenesis and the mechanisms of oxidative stress. -
Endogenous Metabolite
Lophophine hydrochloride is an endogenous metabolite derived from the plant Lophophora diffusa, serving as an important intermediate in the synthesis of anhalonine and lophophorine. This compound exhibits notable biological activity, with anhalonine inducing mild sedative effects in amphibian models, while lophophorine is associated with significant neuroactive responses, including prolonged convulsions, increased reflex excitability, muscle rigidity, and paralysis in both rabbit and frog models. Lophophine hydrochloride is relevant for research in neuropharmacology and the study of natural product-derived compounds. -
Endogenous Metabolite
Diheptanoyl Thio-PC is a substrate designed for the enzymatic activity of phospholipase A2s (PLA2s), excluding cytosolic PLA2 and PAF-acetyl hydrolase. This compound undergoes hydrolysis at the sn-2 position, releasing a free thiol group on lysophospholipid. The resulting free thiol can be quantitatively measured using chromogenic assays, such as DTNB (Ellman’s reagent) and DTP, making it valuable for studies involving phospholipase activity and lipid metabolism. -
Insect Pheromone
(Z)-14-Methyl-8-hexadecenal is a sex pheromone that targets mating behaviors in male Trogoderma beetles. This compound is known to elicit mating responses, making it valuable for studies on insect communication and behavior. Its applications extend to research in chemical ecology and pest management strategies, providing insights into insect attraction and reproductive processes. -
Endogenous Metabolite
Trans-Jasmone is an endogenous metabolite known for its aroma-inducing properties. This compound exhibits potential biological activity and is primarily utilized in the flavoring and fragrance industries to enhance the sensory profile of products. Its role as a flavoring agent makes it valuable for research applications related to aroma chemistry and sensory analysis. -
Endogenous metabolite
Cyclobenzaprine b-D-glucuronide is an endogenous metabolite of Cyclobenzaprine, primarily involved in the drug's metabolic pathways. This compound may facilitate research into the pharmacokinetics of Cyclobenzaprine and its therapeutic applications. Additionally, it holds potential for investigating treatment strategies related to coronavirus infections, thereby contributing to the broader understanding of antiviral therapeutic mechanisms. -
Endogenous Metabolite
C22 Phytoceramide (t18:0/22:0) is an endogenous sphingolipid that plays a vital role in cellular signaling and membrane structure. Isolated from Moro blood orange (Citrus sinensis) peels and present in primary human astrocytes, it is crucial for studying lipid metabolism and neurobiology. This compound is employed in research applications related to skin health, cellular differentiation, and neurodegenerative diseases. -
Endogenous Metabolite
A-395N is a structural analog of A-395, designed as a control probe for research involving the polycomb protein EED. This protein is critical to the Polycomb repressive complex 2 (PRC2), which mediates transcriptional repression through histone H3K27 methylation. A-395N exhibits no pharmacological activity in biochemical or cellular assays, confirming its effectiveness as a control compound in studies exploring EED function and PRC2-related pathways. -
Endogenous Metabolite
(+/-) 13-HODE cholesteryl ester is an endogenous metabolite derived from atherosclerotic lesions, produced through the Cu2+-catalyzed oxidation of low-density lipoprotein (LDL). It is synthesized by the action of lipoxygenase enzymes, particularly 15-lipoxygenase from rabbit reticulocytes and human monocytes, acting on cholesteryl linoleate, a key component of LDL. This compound is essential for studying lipid metabolism and the pathophysiological mechanisms involved in atherosclerosis and related cardiovascular conditions. -
Endogenous Metabolite
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is an endogenous metabolite derived from the bacterium Streptomyces albus. This compound exhibits significant biological activity, facilitating studies in microbiology and metabolic pathways. Its use in research provides insights into natural product biosynthesis and potential applications in antibiotic development. -
Endogenous Metabolite
2-Methyldecanenitrile is an endogenous metabolite known for its distinctive fragrance properties. This compound possesses a rich peach aroma complemented by frankincense undertones, making it suitable for use in perfume formulations. Its remarkable stability across a wide pH range allows it to maintain a consistent fruity effect even at low concentrations, enhancing scent profiles in various applications. -
Endogenous Metabolite
Prostaglandin F2α-1-glyceryl ester serves as an endogenous metabolite targeting 15-hydroxyprostaglandin dehydrogenase (15-HPGDH). This compound plays a role in the regulation of prostaglandin signaling pathways and is essential for studying lipid mediators in various physiological processes. Its biological activity can be leveraged in research applications focused on inflammation, reproductive biology, and vascular function. -
Endogenous Metabolite
PMX 53 monoacetate is a potent orally active antagonist of CD88 (C5aR), primarily inhibiting C5a-induced neutrophil myeloperoxidase release and chemotactic activity. It demonstrates an IC50 of 20 nM for myeloperoxidase release and 75 nM for chemotaxis, making it an effective tool for studying neutrophil responses. Additionally, PMX 53 monoacetate acts as an agonist of MrgX2, further broadening its potential applications in research involving inflammatory processes and pain signaling pathways. -
Endogenous Metabolites
Epoxide hydrolase is an enzyme that catalyzes the hydrolysis of epoxides, converting them into diols. This enzyme is crucial for the metabolism of endogenous metabolites, including environmental pollutants and lipids, thereby facilitating detoxification and modulating inflammatory responses and cardiovascular health. Furthermore, epoxide hydrolase is applicable in asymmetric catalytic reactions, particularly in the asymmetric ring-opening of epoxides, enabling the synthesis of chiral drug molecules for pharmaceutical research. -
Endogenous Metabolite
3-Benzylidenecamphor, an endogenous metabolite, serves primarily as a UV absorber with strong photostability and antioxidant properties. This compound is effective in protecting skin from UV damage and is frequently incorporated into sunscreen formulations. Additionally, 3-Benzylidenecamphor enhances the shelf life and safety of cosmetic products, making it valuable for research into skincare and beauty applications. -
Endogenous Metabolite
Tocol is a synthetic derivative of vitamin E that functions as an endogenous metabolite. Unlike (±)-α-tocopherol, Tocol does not inhibit retinol-induced erythrocyte hemolysis or enhance the microviscosity of rat liver phosphatidylcholine liposomes. This unique profile makes Tocol a valuable tool for research focused on cellular membrane dynamics and vitamin E metabolism. Its distinct biological activity may offer insights into the mechanistic roles of vitamin E derivatives in various physiological contexts. -
Endogenous Metabolite
Sandosaponin A is a saponin that primarily targets human recombinant aldehyde reductase (hAKR1B1), exhibiting notable inhibitory activity. This compound effectively inhibits the reduction of both l-idose and 4-hydroxynonenal, highlighting its role in distinguishing between different aldehyde reductase inhibitors in complex mixtures. The mechanism of inhibition by Sandosaponin A is thought to involve its interaction with diverse substrates, making it a valuable tool for research focused on metabolic pathways and enzyme regulation. -
Endogenous Metabolite
(+)-Norgestrel is a synthetic progestin that primarily targets progesterone receptors to regulate reproductive hormone activity. It is widely utilized in contraceptive formulations and plays a significant role in managing hormonal levels during menopause. Research applications include studies on reproductive health, hormonal therapies, and the mechanism of action of progestins in various biological systems. -
O-Alkyl-N-acyloxy Homologues
Oxy-Arachidonoyl ethanolamide is an O-alkyl-N-acyl oxime derivative that acts on O-Alkyl-N-acyl homologues. This compound exhibits significant biological activity, particularly in the modulation of endocannabinoid systems. It is employed in research applications focusing on cannabinoid receptor signaling, lipid metabolism, and neuroprotective studies, illuminating potential therapeutic pathways for various neurological diseases. -
Endogenous Metabolite
D-Xylonic acid is an endogenous metabolite involved in the interconversion of pentose and glucuronate metabolites. This compound serves as an important intermediate in carbohydrate metabolism and is relevant in studies focused on metabolic pathways. Its biological activity influences various physiological processes, making it valuable for research in biochemistry and metabolic disease. -
Endogenous Metabolite
Glyphosate-13C,15N is a stable isotope-labeled form of glyphosate, incorporating 13C and 15N. This compound serves as an endogenous metabolite and is utilized in metabolic studies to trace absorption, distribution, and metabolism in biological systems. Its unique isotopic labeling facilitates advanced analytical techniques, including mass spectrometry, for investigating the pharmacokinetics and environmental interactions of glyphosate. -
Endogenous Metabolite
Badione A is a naturally occurring metabolite derived from the fungus Xerocomus badius, known for its ability to form stable salts with potassium ions. This compound exhibits potential biological activity that may be valuable in metabolic studies and the exploration of ion interactions in biological systems. Its unique properties make Badione A a useful reagent for research applications in the fields of biochemistry and pharmacology. -
Endogenous Metabolite
Aeruginosin B is a phenazine pigment that functions as an endogenous metabolite, primarily derived from Pseudomonas aeruginosa. This compound demonstrates antimicrobial activity and plays a role in the regulation of various biological processes. Aeruginosin B is often utilized in research to study microbial interactions, pathogenicity, and the biochemical pathways associated with phenazine derivatives. -
Endogenous Metabolite
Ethyl glutamate is an amino acid derivative that acts as an endogenous metabolite, promoting cell growth and proliferation. This compound is valuable in research related to cellular biology and metabolic pathways, providing insights into amino acid metabolism and its effects on cellular processes. Its role in supporting cell viability makes it a useful tool for studies investigating growth factors and metabolic regulation in various biological contexts. -
Endogenous Metabolite
Lipoxin A5 is an endogenous metabolite derived from eicosapentaenoic acid, predominantly found in pig white blood cells. It exhibits contractile activity on guinea pig lung parenchymal strips, demonstrating a force comparable to that of Lipoxin A4 and Lipoxin B4. However, unlike Lipoxin A4 and Lipoxin B4, Lipoxin A5 does not induce vasodilation in aortic smooth muscle. This compound is valuable for research into inflammatory processes and the pharmacological modulation of respiratory function. -
Endogenous Metabolite
8(Z)-Eicosenoic acid is a cis-unsaturated free fatty acid that serves as an endogenous metabolite. This 20-carbon chain fatty acid potentiates acetylcholine receptor channel currents without causing depression and enhances the phosphorylation of protein kinase C epsilon (PKCε) substrates in Xenopus oocytes. It represents approximately 6% of the fatty acid composition in seed oil derived from Bursera collina, making it significant for studies in fatty acid metabolism and receptor pharmacology. -
Endogenous Metabolite
OT-730 is a selective beta-blocker prodrug that targets endogenous metabolites involved in ocular disease pathways. This compound is primarily utilized in research focused on understanding the mechanisms of ocular disorders and the potential therapeutic interventions therein. Its unique pharmacological profile makes it a valuable tool for investigating the role of beta-adrenergic signaling in eye health and disease. -
Endogenous Metabolite
Bhimanone is an endogenous metabolite that exhibits bioinactive properties. Isolated from the genus Streptomyces, this tetralone may serve as a valuable reference compound in metabolic studies. Its structural characteristics can aid in the investigation of biosynthetic pathways and natural product chemistry. -
Endogenous Metabolite
Furan fatty acid F5 (12,15-epoxy-13-methyl-12,14-eicosadienoic acid) is an endogenous metabolite originally isolated from northern pike (Esox lucius). This compound has been shown to exhibit alterations in liver levels during starvation in cod, indicating its potential role in metabolic pathways. Furan fatty acid F5 can be used in research applications aimed at understanding lipid metabolism and the biochemical responses to nutritional stressors. -
Endogenous Metabolite
(E/Z)-Linoleoyl-CoA is an endogenous metabolite that serves as a substrate for analyzing the specificity and kinetics of acyl-CoA. Its unique ability to substitute for different substrates allows for the investigation of amino acid substitutions, which can impact the reactivity with various desaturases. Research involving (E/Z)-Linoleoyl-CoA enhances the understanding of substrate specificity in mammalian fatty acid desaturases and facilitates the development of methods for the efficient production of valuable fatty acids. -
Endogenous Metabolite
Camylofin dihydrochloride is an antispasmodic agent primarily targeting smooth muscle activity. It is effective in alleviating smooth muscle spasms, making it useful in managing conditions such as labor-related discomfort and ulcerative colitis. Additionally, the content of camylofin dihydrochloride in pharmaceutical formulations can be quantitatively analyzed using gas chromatography, facilitating quality control and research applications in therapeutic studies. -
Endogenous Metabolite
N-Acetylciprofloxacin is the metabolic product of the antibiotic Ciprofloxacin. This compound is of interest in studies investigating the pharmacokinetics and metabolic pathways of fluoroquinolones. Its biological activity may offer insights into the safety, efficacy, and potential side effects of Ciprofloxacin in therapeutic applications. Research involving N-Acetylciprofloxacin can aid in understanding antibiotic resistance mechanisms and tissue distribution in various biological systems. -
Insect Pheromone
(2E,13Z)-Octadecadienal is an insect sex pheromone identified for its role in attracting clearwing moths (Synanthedon tipulformis) and raspberry crown borers (Pennisetia marginata). This compound is notable for its capacity to elicit strong antennal responses in male insects, making it a valuable tool in pest management research and the study of insect behavioral ecology. Its isolation from (2E,13Z)-Octadecadienyl acetate further underscores its significance in applications related to insect signaling and attraction mechanisms.
