Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Cephapirin lactone is an endogenous metabolite derived from the antibiotic cephapirin. This compound serves as a significant marker in pharmacokinetic studies and can be utilized to explore metabolic pathways associated with beta-lactam antibiotics. Research applications include investigating the metabolic fate of cephapirin and assessing potential impacts on therapeutic efficacy. -
Endogenous Metabolite
(±)-Mellein is an endogenous metabolite with a chemical structure of 8-hydroxy-3-methyl-3,4-dihydroisochromen-1-one, primarily derived from the marine organism Helicascus kanaloanus. This compound has garnered interest in biochemical research due to its potential biological activity, including roles in cellular signaling and metabolic pathways. Research applications may encompass studies of metabolic processes and effects on various biological systems. -
Fungal Secondary Metabolite
Endocrocin is an anthraquinone and a notable fungal secondary metabolite. It functions primarily as a chemotaxis inhibitor, exhibiting significant immunosuppressive properties. This compound is valuable in research focused on immune response modulation and the study of fungal-derived metabolites in therapeutic applications. -
Endogenous Metabolite
Lignoceroyl ethanolamide is an endogenous metabolite belonging to the fatty N-acyl ethanolamine class, which are recognized as endocannabinoids. This compound may play a role in various biological processes, although the specific functions and significance of its ethanolamine derivative remain to be fully elucidated. Research involving lignoceroyl ethanolamide could provide insights into endocannabinoid signaling pathways and their implications in neurological functions. -
Endogenous Metabolite
Glutamic acid diethyl ester acts as a glutamate antagonist and functions as an endogenous metabolite. This compound is utilized in biochemical research to investigate the mechanisms of glutamate signaling. Additionally, it serves as a precursor for the synthesis of various derivatives and exhibits potential industrial applications. Its unique properties position it as a valuable reagent in compound development efforts. -
Endogenous Metabolite
Methylbenzethonium chloride hydrate is a quaternary ammonium compound that acts as an endogenous metabolite. It exhibits antimicrobial activity and can be utilized in various biochemical research applications, particularly in the study of surface-active agents and their interactions with biological membranes. This reagent is commonly used in experiments involving cell membrane permeability and antimicrobial efficacy assessments. -
Endogenous Metabolite
DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a unique endogenous metabolite that features an inverted charge orientation compared to conventional phosphocholine lipids. This compound contains a quaternary amine located near the bilayer interface, along with a phosphate group extending into the aqueous environment. This distinctive configuration allows for the investigation of biophysical properties and the biological implications of charge inversion at the bilayer surface, making it valuable for studies in membrane biology and lipid interactions. -
Endogenous Metabolite
BFE-37 is an endogenous metabolite that exhibits significant heat resistance, making it ideal for studying microbial stability in food products. It demonstrates a survival rate change of 6.53 log CFU/mL after exposure to 55 °C for 5 minutes in acidic orange juice. The compound's dynamic behavior at varying temperatures reveals a first-order logarithmic linear inactivation characteristic, underscoring its robustness under heat treatment. Research involving BFE-37 contributes to understanding the effects of mild heat treatments on juice products and aids in the development of microbial control strategies within the food industry. -
Endogenous Metabolite
Trans-Phenothrin is a synthetic pyrethroid that primarily targets adult arthropods, exhibiting insecticidal properties against fleas and ticks. Significant differences in biological activity have been observed among its enantiomers when compared to fenvalerate and d-trans-phenothrin. This compound is utilized in agricultural research for its effectiveness as an insecticide against pests like Plutella xylostella, making it a valuable reagent in entomological studies and pest management strategies. -
Endogenous Metabolite
Lentztrehalose A is a trehalose analog that functions as an endogenous metabolite. It exhibits notable antitumor activity and is isolated from actinomycetes. This compound is useful in cancer research and cellular metabolism studies, providing insights into its potential therapeutic applications. -
Endogenous Metabolite
(Z)-Octadec-8-enoic acid, also known as cis-8-octadecenoic acid, is a monounsaturated fatty acid and an essential endogenous metabolite. This compound demonstrates significant biological activity, serving as a key component in lipid metabolism and cellular signaling pathways. Research applications include studies related to metabolism, dietary impacts on health, and the role of fatty acids in various physiological processes. Found naturally in partially hydrogenated vegetable oils and milk fat, it is relevant for investigations into dietary fats and their biological implications. -
Endogenous Metabolite
Isomer-CM 352 is an antifibrinolytic agent targeting matrix metalloproteinases. This compound demonstrates significant ability to reduce hematoma expansion while promoting functional and neurological recovery in models of intracerebral hemorrhage. Isomer-CM 352 enhances neurological outcomes by inhibiting hematoma growth, indicating its potential application in the management of acute neurological conditions. -
Fungal Metabolite
2-(2-Hydroxypropionylamino)-benzamide is a fungal metabolite that functions as a proangiogenic agent. This compound has been shown to stimulate blood vessel formation, making it valuable for research focused on angiogenesis and related biological processes. Its unique properties may provide insights into therapeutic applications in areas such as wound healing and tissue regeneration. -
Endogenous Metabolite
NE58018 is a potent inhibitor of bone resorption, primarily targeting Farnesyl pyrophosphate synthase (FPPS). This compound demonstrates enhanced inhibitory activity due to its structural features and the presence of aminophosphonates. NE58018 modulates the interactions of Thr201 and Tyr204 residues, which are critical for substrate binding and catalysis, thereby increasing the overall inhibition of FPPS. It is useful in research related to bone metabolism and related disorders. -
Endogenous Metabolite
Butenachlor is a selective herbicide targeting endogenous metabolites in plants. It is utilized for the effective control of grass and certain broad-leaved weeds, demonstrating significant herbicidal activity. This compound is primarily applied in agricultural research to study plant physiology and weed management strategies. -
Pheromone
4-Methyl-5-nonanol is a pheromone known for its role in chemical communication among organisms. This compound is significant in various biological activities, including attracting mates and signaling alarm responses. It is utilized in research applications focused on behavioral studies and chemical ecology. -
Insect Pheromone
(E)-10-Dodecenol is an insect pheromone that acts primarily as a signaling compound for communication in certain moth species, notably eliciting electroantennographic responses in male pea moths. This compound plays a crucial role in mating behavior and can be used in research related to pest control and ecological studies of insect behavior. Its specific action in luring male insects makes it valuable for studies focusing on sexual attraction and pheromone signaling pathways. -
Endogenous Metabolite
DL-4-Hydroxy-2-ketoglutarate acts as a substrate for the enzymes glutamic oxalacetic aminotransferase (GOT) and 2-keto-4-hydroxyglutarate aldolase, mediating the reversible conversion of 2-keto-4-hydroxyglutarate to pyruvate and glyoxylate. This endogenous metabolite is valuable in mass spectrometry applications for the rapid analysis of negatively charged, water-soluble cellular metabolites, aiding in metabolic pathway studies and biomarker discovery. -
Endogenous Metabolite
ADR-925 is an active chelated iron metabolite known for its protective effects against doxorubicin-induced damage in neonatal rat cardiomyocytes. This compound plays a crucial role in cellular iron homeostasis and may enhance cell viability under stress conditions. ADR-925 is primarily utilized in research applications focused on cardiotoxicity, metabolic regulation, and iron-related cellular pathways. -
Endogenous Metabolite
Hexaenoic acid is a very long chain polyunsaturated fatty acid (VLCPUFA) that serves as an endogenous metabolite in cellular membranes, particularly in ceramides and sphingomyelin. This C34:6 compound is predominantly found in the retina, sperm, and brain tissues. Its specific biological activities remain largely uncharacterized, but research suggests that it may play a role in the activation of protein kinase C, making it a candidate for studies on lipid signaling and cellular function. -
Endogenous Metabolite
Cyperin is an endogenous metabolite derived from the fungus A. cypericola, primarily targeting enoyl-acyl carrier protein reductase (ENR) in plants, with an IC50 of 89 μM. It exhibits phytotoxic effects by inducing necrosis in various plant species and significantly inhibiting root growth in A. thaliana seedlings, with an IC50 of 38.4 μM. Cyperin serves as a valuable tool for studying plant stress responses and investigating the mechanisms of phytotoxicity in plant biology. -
Endogenous Metabolite
(2R,3R)-2,3,4-Trihydroxybutanoic acid, commonly referred to as erythronic acid, functions as an endogenous metabolite involved in various biological processes. This naturally occurring organic acid is present in multiple biological fluids, including aqueous humor, urine, plasma, cerebrospinal fluid, and synovial fluid, in both healthy adults and children. Its production occurs through the oxidation of GlcNAc, making it a valuable compound for research into metabolic pathways and related health studies. -
Endogenous Metabolite
Methyl dotriacontanoate is a naturally occurring fatty acid methyl ester. It serves as an endogenous metabolite found in the cuticular wax of Picea abies needles and in sediment samples from various geographical locations, including the Harney River in Florida and Lake Kivu in the East African Rift Valley. Its presence in these environments suggests potential roles in ecological and biochemical research applications, particularly in studies related to plant metabolism and natural wax formations. -
Endogenous Metabolite
Glucoberteroin is an endogenous metabolite derived from the glucosinolate family, isolated from Degenia velebitica. It primarily functions by inhibiting protein glycosylation and carbonylation, leading to a reduction in carbonyl protein production. This compound has potential applications in research focused on skin aging and the molecular mechanisms underlying age-related changes in skin biology. -
Endogenous Metabolite
Oleic Acid-2,6-diisopropylanilide is a potent inhibitor of acylCoA:cholesterol acyltransferase (ACAT), a key enzyme involved in the synthesis of cholesteryl esters related to dietary cholesterol absorption, with an IC50 of 7 nM. This compound has demonstrated biological activity by lowering low-density lipoproteins and increasing high-density lipoprotein levels in animal models subjected to high-fat, high-cholesterol diets. It serves as a valuable tool in research applications focused on lipid metabolism and cardiovascular disease. -
Endogenous Metabolite
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside that functions as an endogenous metabolite in various organisms, including humans, E. coli, and mice. It serves as an important intermediate in the biosynthesis of uridine monophosphate (UMP), making it crucial for nucleotide synthesis. This compound is commonly utilized in research to investigate the enzymatic mechanism of orotidine 5′-monophosphate decarboxylase, providing insights into metabolic pathways and cellular function. -
Endogenous Metabolite
Diphenamid is a potent herbicide that primarily targets the enzyme acetyl-CoA carboxylase, inhibiting key metabolic pathways in plants. Its use as a model compound for studying organic pollutants offers insights into wastewater treatment processes, particularly under varying anionic conditions. The degradation pattern of diphenamid is influenced by diverse inorganic ions, including chromium (VI) and nitrogen oxides, while prolonged exposure significantly alters its toxicity profile. Toxicity assessments on selected algal species indicate increased toxicity following extended treatment periods, making diphenamid relevant for environmental toxicity studies and pollutant degradation research. -
Endogenous Metabolite
6,7-Dimethyl-5,6,7,8-tetrahydropterin hydrochloride acts as a synthetic analogue of tetrahydro-L-biopterin, functioning as a crucial cofactor for various nitric oxide synthase isoforms, as well as phenylalanine, tyrosine, and tryptophan hydroxylases. This reagent plays an essential role in metabolic pathways involving neurotransmitter synthesis and is valuable for research into nitric oxide signaling, as well as disorders related to the metabolism of monoamines. Its use facilitates investigations into various physiological and pathological processes linked to these enzymes. -
Endogenous Metabolite
1,2-Dipropionyl-sn-glycero-3-phosphocholine targets the phospholipid characteristics important in membrane biology. This compound serves as an endogenous metabolite and is instrumental in studying the interactions between water molecules and the phosphocholine headgroup in aqueous environments. Its unique structure allows for detailed investigation into membrane dynamics and lipid bilayer properties. -
Endogenous Metabolite
1-(Palmitoyloxy)-3-(stearoyloxy)propan-2-yl oleate is a triacylglycerol comprising palmitic acid at the sn-1 position, oleic acid at the sn-2 position, and stearic acid at the sn-3 position. This compound serves as an important endogenous metabolite and is predominantly found in cocoa butter. Its study can provide insights into lipid metabolism and storage, as well as the physiological roles of triacylglycerols in various biological processes. -
Endogenous Metabolite
Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism. -
Endogenous Metabolite
Metoxuron is a phenylurea herbicide that acts primarily by inhibiting photosynthesis in target plants. It effectively controls a range of annual grasses and broadleaf weeds, making it suitable for use in crops such as wheat, barley, and carrots. This compound serves as a valuable tool in agricultural research focused on weed management and herbicide efficacy studies. -
Endogenous Metabolite
D-Fructose-6-phosphate is an endogenous metabolite that plays a vital role in cellular metabolism through its involvement in the glycolysis and pentose phosphate pathways. This compound influences cell growth and autophagy and can be hydrolyzed by Fructose-1,6-bisphosphatase. Additionally, it can be isomerized to D-glucose-6-phosphate by phosphoglucose isomerase. D-Fructose-6-phosphate serves as a useful reagent for research on metabolic disorders, including studies related to Lewy body dementia. -
Fungal Metabolite
6-Hydroxyramulosin is a fungal metabolite that exhibits significant anticancer activity. It demonstrates cytotoxic effects against human lung cancer A549 and bladder cancer T24 cell lines, with IC50 values of 14.2 µg/mL and 15.3 µg/mL, respectively. This compound may serve as a valuable tool in cancer research, potentially aiding the development of novel therapeutic strategies. -
Endogenous Metabolite
Verdantiol is an endogenous metabolite categorized as a flavanol. It exhibits potential biological activity through its antioxidant properties, contributing to cellular defense mechanisms. This compound is primarily utilized in research applications focusing on metabolic pathways, oxidative stress studies, and evaluating the role of flavanols in human health. -
Endogenous Metabolite
DL-Stearoylcarnitine is the racemic form of Stearoylcarnitine, an endogenous metabolite involved in fatty acid metabolism. It plays a critical role in the transport of long-chain fatty acids into mitochondria for beta-oxidation. This compound is useful in research focused on metabolic disorders, energy metabolism, and mitochondrial dysfunction. Its biological activity can provide insights into lipid metabolism and potential therapeutic targets for related diseases. -
Endogenous Metabolite
18:0,22:6 PS sodium is a phospholipid that plays a critical role in the composition of synaptic vesicles and cholesterol metabolism. This endogenous metabolite is important for studying lipid interactions and their effects on synaptic function. Research applications include investigating neurochemical signaling processes and lipid metabolism in various biological systems. -
Endogenous Metabolite
α-Hydroxytriazolam is a significant endogenous metabolite of ranitidine, primarily acting as a proof-of-concept compound in pharmacokinetic studies. It demonstrates biological activity by influencing drug metabolism and clearance pathways. This compound is particularly relevant in research applications involving drug interactions and the evaluation of metabolic profiles in pharmacological studies. -
Insect Pheromone
(Z)-11-Hexadecenoic acid functions as a sex pheromone specifically targeting male pine processionary moths (Thaumetopoea pityocampa). This compound serves as a useful tool in entomological research and pest management, aiding in the study of insect behavior and the development of attractants for monitoring and controlling pest populations. Its application in ecological studies can help in understanding the interactions between species and their environment. -
Endogenous Metabolite
1,2-Dioleoyl-3-docosohexaenoyl-rac-glycerol is a triacylglycerol comprised of oleic acid at the sn-1 and sn-2 positions, and docosahexaenoic acid at the sn-3 position. This endogenous metabolite is known to be present in human breast milk, highlighting its potential relevance in nutritional and developmental research. It serves as a valuable tool for studying lipid metabolism and elucidating the role of specific fatty acids in cellular processes. -
Endogenous Metabolite
9-OxoODE is an endogenous metabolite formed through the oxidation of the allylic hydroxyl group in either 9(S)- or 9(R)-HODE. This compound is present in rabbit reticulocyte plasma and mitochondrial membranes, accounting for approximately 2% of the total linoleate residues in these membranes. 9-OxoODE is predominantly esterified to membrane lipids, making it relevant for studies investigating lipid metabolism, oxidative stress, and cell membrane dynamics in various biological contexts. -
Insect Pheromone
Nonyl acetate is an insect pheromone that serves as a chemical signal for communication among pea moths (Cydia nigricana). This compound is utilized in research focused on insect behavior, particularly in the study of mating and attraction mechanisms. Its distinctive role in the ecological interactions of pests makes it an important tool for understanding and managing insect populations. -
Endogenous Metabolite
Denagliptin is a small molecule inhibitor of dipeptidyl peptidase IV (DPP-4), primarily targeting endogenous metabolites involved in glucose metabolism. This compound demonstrates significant activity in the research of type 2 diabetes and offers insights into endocrine and metabolic disorders. While stable in the solid state, Denagliptin is known to degrade in solution and in various excipient mixtures, with degradation primarily occurring through cyclization reactions. Understanding its degradation pathways is crucial for advancing formulation development and regulatory compliance. -
Endogenous Metabolite
Platelet aggregation-IN-2 is an endogenous metabolite that functions as an effective anti-platelet aggregation agent. It demonstrates significant anticoagulant properties by inhibiting platelet aggregation, thereby reducing the risk of thrombosis. This compound holds potential applications in the prevention and management of cardiovascular diseases through its capacity to modulate platelet functions. -
Endogenous Metabolite
12(R)-HEPE is a monohydroxy fatty acid derived from eicosapentaenoic acid (EPA) and produced by the eggs of the sea urchin, Strongylocentrotus purpuratus. While the specific biological activities of 12(R)-HEPE remain underexplored, it is hypothesized to exhibit physiological effects akin to those of 12(R)-HETE. This compound serves as a valuable endogenous metabolite for research applications in lipid signaling and inflammatory responses. -
Endogenous Metabolite
L-Primapterin (7-Biopterin) is an endogenous metabolite that serves as a significant biomarker for hyperphenylalaninemia variant primapterinuria. This compound is primarily involved in the metabolism of phenylalanine and is excreted in the urine. Its detection and quantification are essential for research on phenylketonuria and related metabolic disorders, aiding in the understanding of amino acid metabolism and its clinical implications. -
Endogenous Metabolite
Anirolac (RS37326) is a nonsteroidal anti-inflammatory agent that targets endogenous pathways to provide analgesic effects. Demonstrating significant efficacy, Anirolac effectively alleviates moderate to severe postpartum uterine pain, with analgesia scores markedly superior to placebo, particularly at a dose of 100 mg within the first six hours. This compound is valuable for research applications aimed at understanding pain management and inflammation in obstetric contexts. -
Endogenous Metabolite
L-Pyroglutamic acid sodium primarily targets glutathione metabolism and acts as an endogenous metabolite. As the biologically active levo-isomer of pyroglutamic acid, it is involved in key metabolic processes within the body. This compound has been identified as a potential biomarker for systemic lupus erythematosus (SLE), making it a valuable tool in related research applications. -
Endogenous Metabolite
2-Iodoestradiol is a potent ligand for human sex hormone binding globulin (SHBG) with a high binding affinity, demonstrating competition with dihydrotestosterone at the same site on SHBG. Its binding affinity constant at physiological pH and 37 degrees Celsius is 2.4 x 10^9 M^-1, surpassing that of SHBG itself. Additionally, 2-Iodoestradiol can bind to serum albumin, although with reduced affinity. The radioisotope 125I-derivative of this compound is commonly employed in studies investigating the binding dynamics of human SHBG, making it a valuable tool for biological research applications. -
Endogenous Metabolite
Deacetyldiltiazem is an endogenous metabolite primarily acting as a coronary vasodilator. It is found in the plasma of individuals treated with Diltiazem and is metabolized via deacetylation, primarily catalyzed by the rat Ces2a enzyme. In vitro studies reveal that Deacetyldiltiazem exhibits efficient deacetylase activity, with Km values comparable to those observed in rat liver microsomes. Research on Deacetyldiltiazem contributes to the understanding of metabolic kinetic variations of compounds across different species.
