FTY720 (Fingolimod)

Catalog No.: A10408

S1P Receptor antagonist

FTY720 (Fingolimod)

FTY720 (Fingolimod) Chemical Structure

CAS NO. 162359-56-0

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.

Availability: In stock

Package Price Qty
100 mg
$60.00
200 mg
$100.00
500 mg
$200.00
10mM * 1mL in DMSO
$61.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Mayu Idehara, .et al. Inulooligosaccharides in Atractylodis lanceae rhizoma and Atractylodis rhizoma of hochuekkito formula are essential for regulation of the pulmonary immune system of immuno-compromised mice, Traditional & Kampo Medicine, 2020, 22 July
  • Zengzi Zhou, .et al. Effects of immunomodulatory drug Fingolimod (FTY720) on Chlamydia dissemination and pathogenesis, Infect Immun, 2020, Oct 19;88(11):e00281-20 PMID: 32868341
  • Luwa Yuan, .et al. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking, Sci Rep, 2019, 9:11156 PMID: 31371790
  • Sakai Y, .et al. Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system, Int J Biol Macromol, 2018, Nov 22;124:505-514 PMID: 30471397
  • >

Biological Activity

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine.
Targets
S1P receptor (K562, NK cells )
0.033 nM
In vitro (25°C) DMSO 64 mg/mL (186.09 mM)
Water 64 mg/mL (186.09 mM)
Ethanol 64 mg/mL (186.09 mM)
In vivo Saline 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.08 mL 145.39 mL 290.78 mL
0.5 mM 5.82 mL 29.08 mL 58.16 mL
1 mM 2.91 mL 14.54 mL 29.08 mL
5 mM 0.58 mL 2.91 mL 5.82 mL

*The above data is based on the productmolecular weight 343.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10408
Actions Antagonist
CAS No. 162359-56-0
Formula C19H33NO2.HCl
M. Wt 343.9
Purity >98%
Synonyms Gilenia
SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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