JAK / Stat

Items 151 to 175 of 175 total

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  1. AZD3759

    Catalog No. A15551
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    EGFR inhibitor
    AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. Learn More
  2. ASP8273 (Naquotinib)

    Catalog No. A14408
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    irreversible EGFR inhibitor
    ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. Learn More
  3. EGF816 (Nazartinib)

    Catalog No. A14416
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    EGFR T790M inhibitor
    EGF816 is a novel covalent inhibitor of mutant-selective EGFR; overcomes T790M-mediated resistance in NSCLC. Learn More
  4. CL-387785 (EKI-785)

    Catalog No. A13146
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    EGFR inhibitor
    CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level. Learn More
  5. AG-18 (Tyrphostin 23)

    Catalog No. A15940
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    EGFR Inhibitor
    AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell line A431. Learn More
  6. DM1-SMCC

    Catalog No. A15955
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    potent EGFR inhibitor
    DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate. Learn More
  7. PD168393

    Catalog No. A12725
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    EGFR inhibitor
    PD168393 is a potent, cell-permeable, irreversible inhibitor of EGFR with IC50 value of 700 pM. Learn More
  8. EAI045

    Catalog No. A16193
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    EGFR inhbitor
    EAI045 ia a potent and selective EGFR inhbitor. EAI045 targets selected drug-resistant EGFR mutants but spares the wild-type receptor. Learn More
  9. Anlotinib

    Catalog No. A16253
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    EGFR inhibitor
    Anlotinib is a EGFR inhibitor extracted from patent 2015185012 A1, compound 1,which can be used to treat non-small cell lung cancer. Learn More
  10. PD158780

    Catalog No. A16254
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    EGFR inhibitor
    PD158780 is a very potent inhibitor of EGFR with IC50 of 0.08 nM; pan-specific antagonist of ErbB receptor. Learn More
  11. TX1-85-1

    Catalog No. A16361
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    Her3 (ErbB3) ligand
    TX1-85-1 is ErbB3 inhibitor. TX2-121-1 may exert Her3-dependent pharmacology through an allosteric mechanismthereby disrupting interactions between Her3 and other proteins such as Her3 or cMet consistent with results presented here and distinct from conventional kinase inhibitors, which block catalytic function. Learn More
  12. ARRY-380 (Irbinitinib)

    Catalog No. A16413
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    HER2 inhibitor
    ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. Learn More
  13. Erlotinib

    Catalog No. A11416
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    EGFR inhibitor
    Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. When erlotinib binds to EGFR, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated. Learn More
  14. AG-1517

    Catalog No. A13001
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    EGFR inhibitor
    AG 1517 is a potent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR. Learn More
  15. AV412

    Catalog No. A15460
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    EGFR inhibitor
    AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M?and ErbB2, respectively. Learn More
  16. Avitinib (AC0010)

    Catalog No. A16826
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    irreversible EGFR inhibitor
    Avitinib (AC0010) is a pyrrolopyrimidine-based irreversible EGFR inhibitor that is mutation-selective with IC50 value of 0.18 nM against EGFR L858R/T790M double mutations, nearly 43-fold greater potency over wild-type EGFR (IC50 value, 7.68 nM). It has comparable anti-tumor activity and tolerated toxicity. Learn More
  17. Lazertinib (YH25448,GNS-1480)

    Catalog No. A16827
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    EGFR inhibitor
    Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4. Learn More
  18. Tyrphostin AG-528

    Catalog No. A17072
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    EGFR inhibitor
    Tyrphostin AG-528, also known as Tyrphostin B66, is a EGFR protein tyrosine kinase inhibitor. Learn More
  19. Pyrotinib Racemate

    Catalog No. A17068
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    EGFR/HER2 dual inhibitor
    Pyrotinib Racemate is the racemate of Pyrotinib. Pyrotinib is a potent and selective EGFR/HER2 dual inhibitor. Learn More
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    AG-494

    Catalog No. A17142
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    EGFR inhibitor
    AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells. Learn More
  20. Lavendustin A

    Catalog No. A17119
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    EGFR inhibitor
    Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with IC50 value of 11 nM). Learn More
  21. AG-99

    Catalog No. A17123
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    EGFR inhibitor
    AG-99 is an epidermal growth factor receptor (EGFR) kinase inhibitor with IC50 value of 10 μM. Learn More
  22. AG 555

    Catalog No. A18337
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    EGFR inhibitor
    AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor. Learn More
  23. RG14620

    Catalog No. A18327
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    EGFR inhibitor
    RG14620 is an EGFR inhibitor with an IC50 of 3 μM. Learn More
  24. MTX-211

    Catalog No. A18324
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    EGFR/PI3K dual inhibitor
    MTX-211 is a dual inhibitor of EGFR and PI3K, which plays important roles in the progression of KRAS mutant colorectal cancer. MTX-211 has the potential for the treatment of KRAS mutant colorectal cancer. Learn More

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