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PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.05 mL | 175.23 mL | 350.46 mL |
| 0.5 mM | 7.01 mL | 35.05 mL | 70.09 mL |
| 1 mM | 3.5 mL | 17.52 mL | 35.05 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16803 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 285.34 |
| Formula | C15H19N5O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1792180-81-4 |
| Synonyms | PF06651600, PF 06651600 |
| SMILES | C=CC(N1[[email protected]@H](C)CC[[email protected]@H](NC2=C3C(NC=C3)=NC=N2)C1)=O |
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