PF-06651600

Catalog No.: A16803

JAK3 inhibitor

PF-06651600

PF-06651600 Chemical Structure

CAS NO. 1792180-81-4

PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$480.00
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Biological Activity

PF-06651600 is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.05 mL 175.23 mL 350.46 mL
0.5 mM 7.01 mL 35.05 mL 70.09 mL
1 mM 3.5 mL 17.52 mL 35.05 mL
5 mM 0.7 mL 3.5 mL 7.01 mL

*The above data is based on the productmolecular weight 285.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16803
Actions Inhibitor
CAS No. 1792180-81-4
Formula C15H19N5O
M. Wt 285.34
Purity >98%
Synonyms PF06651600, PF 06651600
SMILES C=CC(N1[[email protected]@H](C)CC[[email protected]@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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