JAK3-IN-2

Catalog No.: A18323

JAK3 inhibitor

JAK3-IN-2

JAK3-IN-2 Chemical Structure

CAS NO. 1443235-95-7

JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.

Availability: In stock

Package Price Qty
5 mg
$80.00
10 mg
$140.00
50 mg
$420.00
100 mg
$750.00
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Biological Activity

JAK3-IN-2 is a potent and highly selective JAK3 inhibitor with IC50 of 0.15 nM. dispalys >4,300-fold selectivity over JAK1, JAK2 and TYK2, and other kinases BMX, EGFR, ITK and BTK; blocks cytokine signaling through JAK3, but not through other JAK family enzymes; inhibits IL-7 induced pSTAT5 in CD3+, CD8+ T cells with IC50 of 280 nM; sufficiently blocks the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.54 mL 142.7 mL 285.41 mL
0.5 mM 5.71 mL 28.54 mL 57.08 mL
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL

*The above data is based on the productmolecular weight 350.378. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18323
Actions Inhibitor
M. Wt 350.378
Formula C19H18N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1443235-95-7
Synonyms JAK3 inhibitor 2
SMILES O=C(C1=CNC2=NC=NC(C3=CC=CC(NC(C(C)=C)=O)=C3)=C21)OCC

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