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Biological Activity
MTX-211 is a dual inhibitor of EGFR and PI3K, which plays important roles in the progression of KRAS mutant colorectal cancer. MTX-211 has the potential for the treatment of KRAS mutant colorectal cancer.
| In vitro | DMSO | 22 mg/mL (45.99 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.91 mL | 104.53 mL | 209.06 mL |
| 0.5 mM | 4.18 mL | 20.91 mL | 41.81 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.91 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.3234. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18324 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1952236-05-3 |
| Formula | C20H14Cl2FN5O2S |
| M. Wt | 478.3234 |
| Purity | >98% |
| Synonyms | MTX211, MTX 211 |
| SMILES | CS(=O)(NC1=CC(C2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2)=CN=C1Cl)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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