Upadacitinib (ABT-494)

Catalog No.: A18316

JAK1 Inhibitor

Upadacitinib (ABT-494)

Upadacitinib (ABT-494) Chemical Structure

CAS NO. 1310726-60-3

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2)

Availability: In stock

Package Price Qty
2 mg
$50.00
5 mg
$100.00
10 mg
$150.00
50 mg
$350.00
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Biological Activity

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.45 mL 262.9 mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.15 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18316
Actions Inhibitor
M. Wt 380.37
Formula C17H19F3N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1310726-60-3
Synonyms ABT 494, ABT494
SMILES CCC1CN(CC1C2=CN=C3N2C4=C(NC=C4)N=C3)C(=O)NCC(F)(F)F

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