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JAK1 inhibitor
In Stock
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| Target | Activity | Value |
|---|---|---|
| JAK1 | IC50 | 29 nM |
| JAK2 | IC50 | 803 nM |
| Tyk2 | IC50 | 1253 nM |
| Cell Line | Activity | Value | Description | Reference |
|---|---|---|---|---|
| TF-1 | IC50 | 1.4 μM | Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO addition and further incubated for 4 hrs fluorescence based assay | [PMID: 32462873] |
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1622902-68-4 |
| Applications | JAK1 inhibitor |
| Formula | C14H21N5O2S |
| Molecular Weight | 323.415 |
| Synonyms | PF04965842. PF 04965842; PF-04965842 |
| SMILES | CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2 |
| Solvent | Reported Solubility |
|---|---|
| DMSO | 58 mg/mL (179.34 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
