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Biological Activity
Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.
| In vitro | DMSO | 58 mg/mL (179.34 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.92 mL | 154.6 mL | 309.2 mL |
| 0.5 mM | 6.18 mL | 30.92 mL | 61.84 mL |
| 1 mM | 3.09 mL | 15.46 mL | 30.92 mL |
| 5 mM | 0.62 mL | 3.09 mL | 6.18 mL |
*The above data is based on the productmolecular weight 323.415. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18318 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1622902-68-4 |
| Formula | C14H21N5O2S |
| M. Wt | 323.415 |
| Purity | >98% |
| Synonyms | PF04965842. PF 04965842 |
| SMILES | CN([[email protected]]1C[[email protected]@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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