Abrocitinib (PF-04965842)

Catalog No.: A18318

JAK1 inhibitor

Abrocitinib (PF-04965842)

Abrocitinib (PF-04965842) Chemical Structure

CAS NO. 1622902-68-4

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Availability: In stock

Package Price Qty
5 mg
$180.00
10 mg
$320.00
50 mg
$1,200.00
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Biological Activity

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.
In vitro DMSO 58 mg/mL (179.34 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.92 mL 154.6 mL 309.2 mL
0.5 mM 6.18 mL 30.92 mL 61.84 mL
1 mM 3.09 mL 15.46 mL 30.92 mL
5 mM 0.62 mL 3.09 mL 6.18 mL

*The above data is based on the productmolecular weight 323.415. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18318
Actions Inhibitor
CAS No. 1622902-68-4
Formula C14H21N5O2S
M. Wt 323.415
Purity >98%
Synonyms PF04965842. PF 04965842
SMILES CN([[email protected]]1C[[email protected]@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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