Lazertinib (YH25448,GNS-1480)

Catalog No.: A16827

EGFR inhibitor

Lazertinib (YH25448,GNS-1480)

Lazertinib (YH25448,GNS-1480) Chemical Structure

CAS NO. 1903008-80-9

Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.

Availability: In stock

Package Price Qty
5 mg
$190.00
10 mg
$350.00
50 mg
$950.00
100 mg
$1,600.00
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Biological Activity

Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.15 mL 180.29 mL
0.5 mM 3.61 mL 18.03 mL 36.06 mL
1 mM 1.8 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

*The above data is based on the productmolecular weight 554.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16827
Actions Inhibitor
M. Wt 554.66
Formula C30H34N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1903008-80-9
Synonyms YH 25448, YH-25448, GNS1480, GNS 1480
SMILES C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O

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