Total item
Cart Subtotal
$0.00 Biological Activity
Lazertinib (YH25448,GNS-1480) is a potent, highly mutant-selective and irreversible EGFR-TKI with IC50 values of 1.7 nM, 2 nM, 5 nM, 20.6 nM and 76 nM for Del19/T790M, L858R/T790M, Del19, L85R and Wild type EGFR respectively, showing much higher IC50 values aganist ErbB2 and ErbB4.
| In vitro | DMSO | 4 mg/mL (7.21 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.03 mL | 90.15 mL | 180.29 mL |
| 0.5 mM | 3.61 mL | 18.03 mL | 36.06 mL |
| 1 mM | 1.8 mL | 9.01 mL | 18.03 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.61 mL |
*The above data is based on the productmolecular weight 554.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16827 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1903008-80-9 |
| Formula | C30H34N8O3 |
| M. Wt | 554.66 |
| Purity | >98% |
| Synonyms | YH 25448, YH-25448, GNS1480, GNS 1480 |
| SMILES | C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy Lazertinib (YH25448,GNS-1480) | Lazertinib (YH25448,GNS-1480) Supplier | purchase | cost | manufacturer | order | distributor | buy 1903008-80-9| 1903008-80-9 Supplier | purchase 1903008-80-9 | 1903008-80-9 cost | 1903008-80-9 manufacturer | order 1903008-80-9 | 1903008-80-9 distributor
Adooq Quality Guarantee
We promise all products perform as described.