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Biological Activity
PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).
| In vitro | DMSO | 76 mg/mL (159.35 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.7 mL | 113.52 mL | 227.03 mL |
| 0.5 mM | 4.54 mL | 22.7 mL | 45.41 mL |
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16807 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1210608-43-7 |
| Formula | C24H23F3N4O |
| M. Wt | 440.47 |
| Purity | >98% |
| Synonyms | LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base |
| SMILES | O=C(NC1=C([[email protected]]2C[[email protected]@H](N)C[[email protected]@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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