Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
Biological Activity
PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).
| In vitro | DMSO | 76 mg/mL (159.35 mM) | |
| Water | Insoluble | ||
| Ethanol | 76 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.7 mL | 113.52 mL | 227.03 mL |
| 0.5 mM | 4.54 mL | 22.7 mL | 45.41 mL |
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
*The above data is based on the productmolecular weight 440.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16807 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1210608-43-7 |
| Formula | C24H23F3N4O |
| M. Wt | 440.47 |
| Purity | >98% |
| Synonyms | LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base |
| SMILES | O=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy PIM447 (LGH447) | PIM447 (LGH447) Supplier | purchase | cost | manufacturer | order | distributor | buy 1210608-43-7| 1210608-43-7 Supplier | purchase 1210608-43-7 | 1210608-43-7 cost | 1210608-43-7 manufacturer | order 1210608-43-7 | 1210608-43-7 distributor
Adooq Quality Guarantee
We promise all products perform as described.