PIM447 (LGH447)

Catalog No.: A16807

Pim inhibitor

PIM447 (LGH447)

PIM447 (LGH447) Chemical Structure

CAS NO. 1210608-43-7

PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).

Availability: In stock

Package Price Qty
2 mg
$160.00
5 mg
$380.00
10 mg
$500.00
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Biological Activity

PIM447 is a novel pan-PIM kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. It also inhibits GSK3β, PKN1, and PKCτ, but at a significantly lower potency with IC50 between 1 and 5 μM (>105-fold differential relative to the Ki on PIMs).
In vitro DMSO 76 mg/mL (159.35 mM)
Water Insoluble
Ethanol 76 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.52 mL 227.03 mL
0.5 mM 4.54 mL 22.7 mL 45.41 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16807
Actions Inhibitor
CAS No. 1210608-43-7
Formula C24H23F3N4O
M. Wt 440.47
Purity >98%
Synonyms LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base
SMILES O=C(NC1=C([[email protected]]2C[[email protected]@H](N)C[[email protected]@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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