Fig. 1 · Structure

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SMI-16a

Cat. No. A17157 CAS 587852-28-6

Pim kinase inhibitor

SMI-16a is a selective Pim kinase inhibitor with IC50 values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
PC-12 IC50 7 μM Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay [PMID: 15109648]
PC-3 IC50 48 μM Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay [PMID: 19072652]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 587852-28-6
Applications Pim kinase inhibitor
Formula C13H13NO3S
Molecular Weight 263.31
SMILES
O=C(NC/1=O)SC1=C\C2=CC=C(OCCC)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 52 mg/mL (197.48 mM)
Water Insoluble
Ethanol 4 mg/mL (15.19 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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