• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD

Akt

Items 1-50 of 215

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A11286
    AKT inhibitor VIII (AKTI-1/2)

    AKT inhibitor

    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
    Quick View
  2. A15541
    SC79

    Akt phosphorylation activator

    SC79 is an AKT activator. SC79 binds to the plecktrin homology (PH) domain of Akt that mimics the binding of PtdIns(3,4,5)P3 to induce a conformational change in Akt that enhances phosphorylation and activation.
    Quick View
  3. A10709
    Perifosine (NSC-639966)

    Akt inhibitor

    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
    Quick View
  4. A11034
    A-674563

    Akt inhibitor

    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
    Quick View
  5. A13460
    Deguelin
    Deguelin is a natural product that displays profound antiproliferative activity.
    Quick View
  6. A11030
    GSK690693

    AKT inhibitor

    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
    Quick View
  7. A11759
    Capivasertib (AZD5363)

    AKT inhibitor

    Capivasertib (AZD5363) is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.

    Quick View
  8. A10003
    MK-2206 2HCl

    AKT Inhibitor

    MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
    Quick View
  9. A12404
    ONO 2506
    ONO 2506 inhibits S100B synthesis in activated cultured astrocytes.
    Quick View
  10. A12435
    Akt-l-1

    AKT1 inhibitor

    Akt-I-1 is a specific inhibitor of Akt1 (IC(50) 4.6 μM) and does not inhibit AKT2, or AKT3
    Quick View
  11. A12464
    AT13148

    multi-AGC kinase inhibitor

    AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
    Quick View
  12. A12720
    TIC10 isomer

    AKT inhibitor

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics.
    Quick View
  13. A12877
    KP372-1

    Akt Inhibitor

    KP372-1 is a synthetic small molecule AKT inhibitor.
    Quick View
  14. A13030
    Afuresertib HCl

    AKT inhibitor

    Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
    Quick View
  15. A13210
    Triciribine

    AKT Inhibitor

    Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt.
    Quick View
  16. A13364
    Borussertib

    Akt inhibitor

    Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt.
    Quick View
  17. A11246
    GDC-0068 (Ipatasertib, RG-7440)

    Akt Inhibitor

    GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
    Quick View
  18. A11262
    Cenisertib

    multi-kinase inhibitor

    Cenisertib (AS-703569) is a multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3.
    Quick View
  19. A11285
    AKT Kinase Inhibitor

    Akt kinase inhibitor

    AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
    Quick View
  20. A11287
    A-443654

    Akt inhibitor

    A-443654, a specific Akt inhibitor with Ki value of 160 pM, interferes with mitotic progression and bipolar spindle formation.
    Quick View
  21. A11453
    Isobavachalcone

    Akt inhibitor

    Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM).
    Quick View
  22. A12081
    SC 66

    Akt inhibitor

    SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo.
    Quick View
  23. A13554
    SR-13668

    AKT inhibitor

    SR-13668 is an Akt inhibitor, is also an orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities.
    Quick View
  24. A13590
    10-DEBC HCl

    AKT/PKB inhibitor

    10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein.
    Quick View
  25. A14121
    CTX 0294885

    Broad-Spectrum Kinase Inhibitor

    CTX-0294885 is a novel broad-spectrum kinase inhibitor. CTx-0294885 exhibits inhibitory activity against a broad range of kinases in vitro.
    Quick View
  26. A14138
    Miltefosine

    PI3K/Akt inhibitor

    Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa
    Quick View
  27. A15809
    GSK2141795 (Uprosertib, GSK795)

    Akt inhibitor

    Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
    Quick View
  28. A15903
    TIC10

    Akt Inhibitor

    TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2.
    Quick View
  29. A16233
    Tomatidine

    ERK/Akt/NF-kB inhibitor

    Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
    Quick View
  30. A16285
    Akt1 and Akt2-IN-1

    AKT 1/2 inhibitor

    Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
    Quick View
  31. A16286
    ARQ-092 (Miransertib)

    AKT inhibitor

    ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
    Quick View
  32. A16392
    Afuresertib

    Akt inhibitor

    Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
    Quick View
  33. A20847
    AS194949

    SHIP-2 inhibitor

    AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5?? phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
    Quick View
  34. A20924
    3CAI

    AKT1/AKT2 inhibitor

    3CAI is a potent and specific AKT1 and AKT2 inhibitor.
    Quick View
  35. A21009
    AKT-IN-1

    AKT inhibitor

    AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM.
    Quick View
  36. A21053
    GSK2110183 analog 1
    GSK2110183 analog 1 is the structural analogue of GSK2110183.
    Quick View
  37. A21087
    Solenopsin

    ATP-competitive AKT inhibitor

    Solenopsin is an ATP-competitive AKT inhibitor with IC50 value of 10 μM .
    Quick View
  38. A21198
    YS-49

    PI3K/Akt activator

    YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells.
    Quick View
  39. A19825
    Guggulsterone
    Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt.
    Quick View
  40. A20147
    AKT-IN-2

    AKT inhibitor

    AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1.
    Quick View
  41. A20255
    Recilisib (free acid)

    radioprotectant

    Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
    Quick View
  42. A20421
    BAY1125976

    allosteric Akt1/Akt2 inhibitor

    BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
    Quick View
  43. A15006
    AT7867 2HCl

    Akt inhibitor

    AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
    Quick View
  44. A17293
    4-Methylbenzylidene camphor
    4-Methylbenzylidene camphor(4-MBC; Enzacamene)is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation.
    Quick View
  45. A36695
    9(10)-Nitrooleate

    Akt Activator

    9(10)-Nitrooleate is an Akt activator that enhances enzymatic activity and promotes nitric oxide bioavailability. By inducing the phosphorylation of Akt and ERK1/2, it regulates the multi-site phosphorylation of eNOS and optimizes its interaction with Hsp90, contributing to its vasoprotective effects. Additionally, 9(10)-Nitrooleate activates PPARα, PPARδ, and PPARγ receptors, influencing adipogenesis, glucose uptake, and inflammatory gene expression. Its immunosuppressive properties also inhibit neutrophil migration and cytokine secretion, making it valuable for research on sepsis and related inflammatory conditions.
    Quick View
  46. A36706
    PI3K/AKT/ERK/CREB activator 1

    PI3K/AKT/ERK/CREB Activator

    PI3K/AKT/ERK/CREB Activator 1 is a small molecule that stimulates the PI3K/AKT/ERK/CREB signaling pathway. It enhances neuronal survival and proliferation, promoting the viability of damaged neurons and facilitating synapse formation. This compound also reduces neuroinflammation by decreasing pro-inflammatory cytokine levels, and it has shown potential in preserving synaptic structure and improving spatial memory in Alzheimer's disease models. PI3K/AKT/ERK/CREB Activator 1 is a valuable tool for research focused on neurodegenerative disorders, particularly Alzheimer's disease.
    Quick View
  47. A36751
    D-87503

    PI3k/Akt/mTOR Inhibitor

    D-87503 is a potent inhibitor of the PI3K/Akt/mTOR signaling pathway, exhibiting IC50 values of 62 nM for PI3K and 0.76 μM for Erk2. This compound effectively attenuates the activity of downstream substrates, including Akt and Rsk1, making it a valuable tool for studying cellular processes regulated by this pathway. D-87503 has applications in cancer research and investigates the role of PI3K signaling in various physiological conditions.
    Quick View
  48. A36155
    19-epi-Scholaricine

    AKT/mTOR Inhibitor

    19-epi-Scholaricine is a potent AKT/mTOR inhibitor, classified as an orally active indole alkaloid. This compound downregulates profibrotic and apoptotic proteins, such as HRAS, HSP90AA1, and KDR, while upregulating the cell cycle regulator CDK2. Furthermore, 19-epi-Scholaricine inhibits ROS production and reduces inflammatory mediator release, leading to decreased podocyte apoptosis, renal inflammation, and oxidative stress. It is a valuable tool for research into chronic glomerulonephritis and membranous nephropathy.
    Quick View
  49. A31961
    Propylparaben sodium

    Estrogen Receptor Agonist, Voltage-Gated Sodium Channel Blocker, PI3K-AKT/JNK Signaling Modulator,

    Propylparaben sodium acts as a weak estrogen receptor agonist and serves as a voltage-gated sodium channel blocker, while also modulating the PI3K-AKT and JNK signaling pathways. It is known to induce oxidative stress, affecting the estrous cycle and hormone levels, as well as ovarian reserve function. Propylparaben sodium can inhibit the growth of antral follicles and influence the accumulation of steroid hormones in follicle culture media. This compound is suitable for research related to ovarian aging and myocardial ischemia-reperfusion injury.
    Quick View
  50. A31975
    Ephemeranthol A

    NF-κB/MAPK/FAK/Akt Inhibitor

    Ephemeranthol A is an inhibitor of NF-κB, MAPK, FAK, and Akt signaling pathways. This phenanthrene compound demonstrates notable anti-inflammatory effects through the inhibition of NF-κB and MAPK pathways in macrophages. Additionally, Ephemeranthol A induces apoptosis and inhibits metastasis in non-small cell lung cancer by suppressing FAK/Akt signaling and epithelial-mesenchymal transition (EMT) processes. It is applicable for research into acute and chronic inflammatory diseases as well as non-small cell lung cancer.
    Quick View

Items 1-50 of 215

Page
per page
Set Descending Direction