Akt

Inhibitory Selectivity
Catalog No.Inhibitor Name Akt Akt1 Akt2 Akt3 Other Targets
A10003MK-2206 2HCl
***
***
**
A10709Perifosine
*
A11030GSK690693
****
***
***
PKCθ,PKCη,PrkX
A11246Ipatasertib
****
**
***
A11759AZD5363
****
***
***
ROCK2
A11024PF-04691502
****
PI3Kδ,PI3Kα,PI3Kγ
A10094AT7867
**
***
**
PKA,p70 S6K
A13210Triciribine
*
HIV-1
A11031CCT128930
****
p70 S6K,PKA
A11034A-674563
***
PKA,CDK2,GSK-3β
A11032PHT-427
*
PDK-1
A11286Akti-1/2
**
*
*
A15809Uprosertib
*
*
**
A16392Afuresertib
****
****
****
A12464AT13148
**
*
**
PKA,ROCK2,ROCK1
A14138Miltefosine
PI3K,PKC
A10453Honokiol
MEK
A12720TIC10 Analogue
ERK
A13460Deguelin
PI3K
A15903TIC10
ERK
A11287A-443654
****
A1359010-DEBC HCl
*
A16286ARQ-092 (Miransertib)
****
****
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



Items 1 to 25 of 32 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
Catalog No. Product Name Application Product Information
A13590

10-DEBC HCl

AKT/PKB inhibitor‎
10-DEBC HCl is a selective inhibitor of Akt/PKB. It inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 ??M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein.
A11287 SALE

A-443654

Akt inhibitor
A-443654, a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation.
A11034 SALE

A-674563

Akt inhibitor
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
A16392

Afuresertib

Akt inhibitor
Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
A13030 SALE

Afuresertib HCl

AKT inhibitor‎
Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
A11286 SALE

AKT inhibitor VIII (AKTI-1/2)

AKT inhibitor
AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 ?M for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
A16285

Akt1 and Akt2-IN-1

AKT inhibitor
Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity.
A16286

ARQ-092 (Miransertib)

AKT inhibitor
ARQ 092 is an oral activie, potent and selective AKT inhibitor with IC50 values: 5.0 nM (AKT1); 4.5 nM (AKT2); 16 nM (AKT3).
A12464

AT13148

multi-AGC kinase inhibitor
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
A10094

AT7867

AKT inhibitor
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
A15006

AT7867 2HCl

Akt inhibitor
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
A11759 SALE

AZD5363

AKT inhibitor
AZD5363 is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.
A11031 SALE

CCT128930

AKT Inhibitor
CCT128930 is an ATP-competitive AKT inhibitor that is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference.
A13460 SALE

Deguelin

-
Deguelin is a natural product that displays profound antiproliferative activity.
A11246 SALE

GDC-0068

Akt Inhibitor
GDC-0068 is an ATP-competitive small molecule inhibitor of all three isoforms of Akt
A15809

GSK2141795 (Uprosertib, GSK795)

Akt inhibitor
Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
A11030 SALE

GSK690693

AKT inhibitor
GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor.
A10453 SALE

Honokiol

Antiangiogenic and Antitumor Agent
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
A12877

KP372-1

Akt Inhibitor
KP372-1 is a synthetic small molecule AKT inhibitor.
A14138

Miltefosine

PI3K/Akt inhibitor
Miltefosine inhibits PI3K/Akt activity with ED50 of 17.2 μM and 8.1 μM in carcinoma cell lines A431 and HeLa
A10003 SALE

MK-2206 2HCl

AKT Inhibitor
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively.
A10709 SALE

Perifosine (NSC-639966)

Akt inhibitor
Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
A11024 SALE

PF-04691502

PI3K/mTOR Inhibitor
PF-04691502 is a PI3K/mTOR kinase inhibitor, is also an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway.
A11032 SALE

PHT-427

AKT Inhibitor
PHT-427 is a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
A12081 SALE

SC 66

Akt inhibitor
SC 66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. It exhibits anticancer activity in vitro and in vivo.

Items 1 to 25 of 32 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction