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Biological Activity
Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.
| In vitro | DMSO | 79 mg/mL (184.87 mM) | |
| Water | Insoluble | ||
| Ethanol | 79 mg/mL (184.87 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.4 mL | 117.01 mL | 234.02 mL |
| 0.5 mM | 4.68 mL | 23.4 mL | 46.8 mL |
| 1 mM | 2.34 mL | 11.7 mL | 23.4 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
*The above data is based on the productmolecular weight 427.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16392 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1047644-62-1 |
| Formula | C18H17Cl2FN4OS |
| M. Wt | 427.32 |
| Purity | >98% |
| Synonyms | GSK 2110183, GSK2110183, GSK-2110183 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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