Signaling Pathway
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| Discription | Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2. | ||
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| Catalog Num | A16392 |
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| Formula | C18H17Cl2FN4OS |
| Molecular Weight | 427.32 |
| CAS Number | 1047644-62-1 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl |
| Synonyms | GSK 2110183, GSK2110183, GSK-2110183 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 79 mg/mL (184.87 mM) | |
| Water | Insoluble | ||
| Ethanol | 79 mg/mL (184.87 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.4 mL | 117.01 mL | 234.02 mL |
| 0.5 mM | 4.68 mL | 23.4 mL | 46.8 mL |
| 1 mM | 2.34 mL | 11.7 mL | 23.4 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.68 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
