MEK/ERK

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  1. Inhibitor (33)


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Catalog No. Product Name Product Information
A12002

Arctigenin

Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM)
A10089

AS703026 (Pimasertib)

AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
A10257

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
A10115

AZD8330

AZD8330 is a MEK inhibitor that specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation.
A15762

BI-847325

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A10151

BIX 02189

BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
A10150

BIX02188

BIX02188 is a potent and selective inhibitor of MEK5.
A11927

Chlortetracycline Hydrochloride

Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic.
A15051

Cobimetinib (R-enantiomer)

Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
A15050

Cobimetinib (racemate)

Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
A14380

G-479

G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
A12974

GDC-0623

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
A11441

GDC-0973

GDC-0973, a selective inhibitor of MEK, also known as mitogen activated protein kinase kinase (MAPKK), is a key component of the RAS/RAF/MEK/ERK pathway, which is frequently activated in human tumors.
A11029

GSK1120212 (JTP-74057, Trametinib)

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
A10453

Honokiol

Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
A13135

Kobe0065

Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells.
A15157

MEK inhibitor

MEK inhibitor is a potent MEK inhibitor, antitumor agent.
A11493

MEK162 (ARRY-438162, Binimetinib)

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
A16032

PD 198306

PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
A16044

PD 334581

PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1.
A10256

PD0325901

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
A10212

PD184352 (CI-1040)

PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK).
A10704

PD318088

PD318088 is an inhibitor of MEK1 AND MEK2.
A10705

PD98059

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
A11264

Refametinib

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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