MEK162 (ARRY-438162, Binimetinib)

Catalog No.: A11493

MEK1/2 inhibitor

MEK162 (ARRY-438162, Binimetinib)

MEK162 (ARRY-438162, Binimetinib) Chemical Structure

CAS NO. 606143-89-9

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$60.00
50 mg
$90.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • S Shahab, .et al. MEK Inhibition Suppresses Growth of Atypical Teratoid/Rhabdoid Tumors, J Neuropathol Exp Neurol, 2020, Jul 1;79(7):746-753
  • Seidel D, .et al. A multidimensional impedance platform for the real-time analysis of single and combination drug pharmacology in patient-derived viable melanoma models, Biosens Bioelectron, 2019, Jan 1;123:185-194 PMID: 30201332
  • Alquezar C, .et al. Increasing progranulin levels and blockade of the ERK1/2 pathway: Upstream and downstream strategies for the treatment of progranulin deficient frontotemporal dementia, Eur Neuropsychopharmacol, 2015, Mar;25(3):386-403 PMID: 25624003

Biological Activity

MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
Targets
MEK
12 nM
In vitro (25°C) DMSO 88 mg/mL (199.44 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.73 mL 113.64 mL 227.27 mL
0.5 mM 4.55 mL 22.73 mL 45.45 mL
1 mM 2.27 mL 11.36 mL 22.73 mL
5 mM 0.45 mL 2.27 mL 4.55 mL

*The above data is based on the productmolecular weight 440.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11493
Actions Inhibitor
M. Wt 440.0
Formula C17H15BrF2N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 606143-89-9
Synonyms ARRY-162, MEK-162, MEK 162
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

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