Trametinib (DMSO solvate)

Catalog No.: A21450

MEK inhibitor

Trametinib (DMSO solvate)

Trametinib (DMSO solvate) Chemical Structure

CAS NO. 1187431-43-1

Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.

Availability: In stock

Package Price Qty
10 mg
$54.00
25 mg
$108.00
50 mg
$186.00
100 mg
$318.00
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Biological Activity

Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.42 mL 72.09 mL 144.19 mL
0.5 mM 2.88 mL 14.42 mL 28.84 mL
1 mM 1.44 mL 7.21 mL 14.42 mL
5 mM 0.29 mL 1.44 mL 2.88 mL

*The above data is based on the productmolecular weight 693.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21450
Actions Inhibitor
M. Wt 693.53
Formula C28H29FIN5O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1187431-43-1
Synonyms GSK-1120212 (DMSO solvate), GSK1120212, GSK 1120212; JTP-74057 (DMSO solvate), JTP74057, JTP 74057
SMILES CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O

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