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- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Biological Activity
Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.42 mL | 72.09 mL | 144.19 mL |
| 0.5 mM | 2.88 mL | 14.42 mL | 28.84 mL |
| 1 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
*The above data is based on the productmolecular weight 693.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21450 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1187431-43-1 |
| Formula | C28H29FIN5O5S |
| M. Wt | 693.53 |
| Purity | >98% |
| Synonyms | GSK-1120212 (DMSO solvate), GSK1120212, GSK 1120212; JTP-74057 (DMSO solvate), JTP74057, JTP 74057 |
| SMILES | CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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