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Biological Activity
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
Targets
| MEK1 | ||||
| 3.2 nM |
| In vitro | DMSO | 99 mg/mL (196.33 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.83 mL | 99.17 mL | 198.33 mL |
| 0.5 mM | 3.97 mL | 19.83 mL | 39.67 mL |
| 1 mM | 1.98 mL | 9.92 mL | 19.83 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.97 mL |
*The above data is based on the productmolecular weight 504.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11040 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1035555-63-5 |
| Formula | C17H15F2IN4O4 |
| M. Wt | 504.2 |
| Purity | >98% |
| Synonyms | TAK733 |
| SMILES | CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)C[[email protected]](CO)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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