Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Chia-Chi Chang, .et al. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057
Biological Activity
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
Targets
MEK1 (Cell-free assay) | ||||
14 nM |
In vitro (25°C) | DMSO | Warmed: 80 mg/mL (174.79 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 21.85 mL | 109.24 mL | 218.48 mL |
0.5 mM | 4.37 mL | 21.85 mL | 43.7 mL |
1 mM | 2.18 mL | 10.92 mL | 21.85 mL |
5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10257 |
---|---|
Actions | Inhibitor |
CAS No. | 606143-52-6 |
Formula | C17H15BrClFN4O3 |
M. Wt | 457.7 |
Purity | >98% |
Synonyms | ARRY-142886 |
SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD184352 (CI-1040)
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 th…
TCS ERK 11e (VX-11e)
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are
PD 334581
PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor…
PD318088
PD318088 is an inhibitor of MEK1 AND MEK2.
Refametinib
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
RO4927350
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Keywords:buy AZD6244 (Selumetinib) | AZD6244 (Selumetinib) Supplier | purchase | cost | manufacturer | order | distributor | buy 606143-52-6| 606143-52-6 Supplier | purchase 606143-52-6 | 606143-52-6 cost | 606143-52-6 manufacturer | order 606143-52-6 | 606143-52-6 distributor