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AZD6244 (Selumetinib)

Catalog No.: A10257

MEK inhibitor

AZD6244 (Selumetinib)

AZD6244 (Selumetinib) Chemical Structure

CAS NO. 606143-52-6

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

Availability: In stock

Package Price Qty
100 mg
250 mg
500 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chia-Chi Chang, .et al. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057

Biological Activity

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
MEK1 (Cell-free assay)
14 nM
In vitro (25°C) DMSO Warmed: 80 mg/mL (174.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.85 mL 109.24 mL 218.48 mL
0.5 mM 4.37 mL 21.85 mL 43.7 mL
1 mM 2.18 mL 10.92 mL 21.85 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10257
Actions Inhibitor
CAS No. 606143-52-6
Formula C17H15BrClFN4O3
M. Wt 457.7
Purity >98%
Synonyms ARRY-142886

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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