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AZD6244 (Selumetinib)

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AZD6244 (Selumetinib)

Name: AZD6244 (Selumetinib)
Brand: Adooq Bioscience
SKU: A10257
Rating: 100 (1 reviews)

Catalog No.: A10257

MEK inhibitor

Product Citations (1)

AZD6244 (Selumetinib) Chemical Structure

CAS NO. 606143-52-6

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

Availability: In stock

Package	Price	Qty
100 mg	Regular Price: $80.00 Special Price $64.00
250 mg	Regular Price: $150.00 Special Price $120.00
500 mg	Regular Price: $250.00 Special Price $200.00
10mM * 1mL in DMSO	Regular Price: $64.00 Special Price $51.20
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AZD6244 (Selumetinib)

Chia-Chi Chang, .et al. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 PMID: 27150057

Biological Activity

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

Targets

MEK1 (Cell-free assay)
14 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 80 mg/mL (174.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.85 mL	109.24 mL	218.48 mL
0.5 mM	4.37 mL	21.85 mL	43.7 mL
1 mM	2.18 mL	10.92 mL	21.85 mL
5 mM	0.44 mL	2.18 mL	4.37 mL

*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10257
Actions	Inhibitor
CAS No.	606143-52-6
Formula	C17H15BrClFN4O3
M. Wt	457.7
Purity	>98%
Synonyms	ARRY-142886
SMILES	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.