AZD6244 (Selumetinib)

Catalog No.: A10257

MEK inhibitor

AZD6244 (Selumetinib) Chemical Structure

CAS NO. 606143-52-6

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

Availability: In stock

Package Price Qty
100 mg
$80.00
250 mg
$150.00
500 mg
$250.00
10mM * 1mL in DMSO
$64.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
Targets
MEK1 (Cell-free assay)
14 nM
In vitro (25°C) DMSO 91 mg/mL heating (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.85 mL 109.24 mL 218.48 mL
0.5 mM 4.37 mL 21.85 mL 43.7 mL
1 mM 2.18 mL 10.92 mL 21.85 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10257
Actions Inhibitor
M. Wt 457.7
Formula C17H15BrClFN4O3
Solubility DMSO>92mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 606143-52-6
Synonyms ARRY-142886
SMILES CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

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