Other Countries
You have no items in your shopping cart.
Publications citing Adooq Products
AZD6244 (Selumetinib) Citations (1)
- Chia-Chi Chang,et al. Upregulation of lactate dehydrogenase a by 14-3-3汎 leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 27150057
Chemical Information
| Catalog Num | A10257 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 457.7 |
| Formula | C17H15BrClFN4O3 |
| Solubility | DMSO>92mg/mL Water<1mg/mL Ethanol<1mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 606143-52-6 |
| Synonyms | ARRY-142886 |
| SMILES code | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| Chemical Name | 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide |
Description |
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 91 mg/mL heating (198.82 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.85 mL | 109.24 mL | 218.48mL |
| 0.5 mM | 4.37 mL | 21.85 mL | 43.7 mL |
| 1 mM | 2.18 mL | 10.92 mL | 21.85 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$40.50
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2. ...
Special Price Starting at: $40.50
Special Price Starting at:
$250.00
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. ...
Special Price Starting at: $250.00
Special Price Starting at:
$140.00
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1. ...
Special Price Starting at: $140.00
Special Price Starting at:
$81.00
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. ...
Special Price Starting at: $81.00
Special Price Starting at:
$220.00
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. ...
Special Price Starting at: $220.00
Special Price Starting at:
$108.00
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when ...
Special Price Starting at: $108.00
Special Price Starting at:
$94.50
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well a ...
Special Price Starting at: $94.50
Special Price Starting at:
$36.00
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases. ...
Special Price Starting at: $36.00
Special Price Starting at:
$45.00
Kobe0065 inhibits anchorage-dependent and -independent growth, blocks MEK/ERK activity and induces apoptosis in H-rasG12V transformed NIH3T3 cells. ...
Special Price Starting at: $45.00
Special Price Starting at:
$81.00
VRT752271 is a pyrrole inhibitors of ERK protein kinase. ...
Special Price Starting at: $81.00
Special Price Starting at:
$165.00
Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). ...
Special Price Starting at: $165.00
Special Price Starting at:
$45.00
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. ...
Special Price Starting at: $45.00
Special Price Starting at:
$214.00
Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. ...
Special Price Starting at: $214.00
Special Price Starting at:
$90.00
BIX02188 is a potent and selective inhibitor of MEK5. ...
Special Price Starting at: $90.00
Special Price Starting at:
$83.70
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor . ...
Special Price Starting at: $83.70
Special Price Starting at:
$50.00
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. ...
Special Price Starting at: $50.00
Special Price Starting at:
$99.00
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. ...
Special Price Starting at: $99.00
Special Price Starting at:
$160.00
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor. ...
Special Price Starting at: $160.00
Special Price Starting at:
$110.00
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1. ...
Special Price Starting at: $110.00
Special Price Starting at:
$36.00
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in ...
Special Price Starting at: $36.00
Special Price Starting at:
$36.00
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2. ...
Special Price Starting at: $36.00
Special Price Starting at:
$200.00
G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects. ...
Special Price Starting at: $200.00
Special Price Starting at:
$81.00
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. ...
Special Price Starting at: $81.00
Special Price Starting at:
$140.00
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. ...
Special Price Starting at: $140.00
Special Price Starting at:
$27.00
Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic. ...
Special Price Starting at: $27.00
Special Price Starting at:
$200.00
MEK inhibitor is a potent MEK inhibitor, antitumor agent. ...
Special Price Starting at: $200.00
Special Price Starting at:
$36.00
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. ...
Special Price Starting at: $36.00
Special Price Starting at:
$76.50
Arctigenin is an antioxidant, anti-inflammatory, antiproliferative and antiviral agent. It inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation ( ...
Special Price Starting at: $76.50
Special Price Starting at:
$36.00
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous ...
Special Price Starting at: $36.00
Special Price Starting at:
$140.00
Cobimetinib is a potent, highly selective inhibitor of MEK1/2. ...
Special Price Starting at: $140.00
Keywords:buy AZD6244 (Selumetinib) | AZD6244 (Selumetinib) Supplier | purchase AZD6244 (Selumetinib) | AZD6244 (Selumetinib) cost | AZD6244 (Selumetinib) manufacturer | order AZD6244 (Selumetinib) | AZD6244 (Selumetinib) distributor | buy 606143-52-6| 606143-52-6 Supplier | purchase 606143-52-6 | 606143-52-6 cost | 606143-52-6 manufacturer | order 606143-52-6 | 606143-52-6 distributor
We Using Safe Payments:
