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AZD6244 (Selumetinib)

MEK inhibitor

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Catalog No. A10257

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AZD6244 100mg A10257-100
€76.00
AZD6244 250mg A10257-250
€142.50
AZD6244 500mg A10257-500
€237.50
AZD6244 (Selumetinib) 10mM * 1mL in DMSO A10257-10mM-D
€60.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.

AZD6244 (Selumetinib)

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Publications citing Adooq Products
AZD6244 (Selumetinib)  Citations (1)
  • Chia-Chi Chang,et al. Upregulation of lactate dehydrogenase a by 14-3-3汎 leads to increased glycolysis critical for breast cancer initiation and progression, Oncotarget, 2016, Jun 7; 7(23): 35270-35283 27150057

Chemical Information

Catalog Num A10257
Actions Inhibitor
M. Wt 457.7
Formula C17H15BrClFN4O3
Solubility DMSO>92mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 606143-52-6
Synonyms ARRY-142886
SMILES code CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO
Chemical Name 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Biological Activity

Description
 AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
Targets
MEK1 (Cell-free assay)
14 nM

Solubility

Solubility (25°C) * In vitro DMSO 91 mg/mL heating (198.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.85 mL 109.24 mL 218.48mL
0.5 mM 4.37 mL 21.85 mL 43.7 mL
1 mM 2.18 mL 10.92 mL 21.85 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 457.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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