GSK1120212 (JTP-74057, Trametinib)

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
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Product Name Price Stock Qty
GSK1120212 5mg
$30.00
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GSK1120212 10mg
$50.00
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GSK1120212 50mg
$80.00
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GSK1120212 100mg
$120.00
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GSK1120212 10mM * 1mL in DMSO
$55.00
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Adooq Products cited in reputable paper
Adooq's GSK1120212 (JTP-74057, Trametinib) has been cited by 14 publications
  • Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591
  • Meenu Kesarwani, .et al. , Blood Adv, 2024, Jun 11;8(11):2765-2776 PMID: 38531054
  • Saeko Yoshioka, .et al. , Int J Tryptophan Res, 2022, Nov 30;15 PMID: 36467776
  • Tsung-Ming Chang, .et al. , Journal of Biomedical Science, 2022, 29:92
  • Nao Yamagishi, .et al. , Biol Pharm Bull, 2022, 45(10):1553-1558 PMID: 36184515
  • Hayato Mizuta, .et al. , Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640
  • Keisuke Yanagida, .et al. , Dev Cell, 2020, 52 (6), 779-793 PMID: 32059774
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Kanemaru Y, .et al. , Acta Neuropathol Commun, 2019, Jul 25;7(1):119 PMID: 31345255
  • Chul Min Park, .et al. , Oncol Lett, 2018, Feb; 15(2): 1758-1762 PMID: 29434871
  • Sumi T, .et al. , Biochem Biophys Res Commun, 2018, Jun 18;501(1):253-258 PMID: 29727601
  • Toshiyuki Sumi, .et al. , Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Yuki Kawasaki, .et al. , Sci Rep, 2016, 6: 31502 PMID: 27531070
  • Biological Activity
    Discription GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
    Targets
    Target Value
    Product Information
    Catalog Num A11029
    Formula C26H23FIN5O4
    Molecular Weight 615.4
    CAS Number 871700-17-3
    SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
    Synonyms GSK-1120212, GSK212, Trametinib
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 19 mg/mL (30.87 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 4% DMSO+corn oil 2 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.25 mL 81.25 mL 162.5 mL
    0.5 mM 3.25 mL 16.25 mL 32.5 mL
    1 mM 1.62 mL 8.12 mL 16.25 mL
    5 mM 0.32 mL 1.62 mL 3.25 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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