GSK1120212 (JTP-74057, Trametinib)

Catalog No.: A11029

MEK Inhibitor

GSK1120212 (JTP-74057, Trametinib) Chemical Structure

CAS NO. 871700-17-3

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $32.00

10 mg

Regular Price: $60.00

Special Price $48.00

50 mg

Regular Price: $80.00

Special Price $64.00

100 mg

Regular Price: $120.00

Special Price $96.00

10mM * 1mL in DMSO
$55.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Targets
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
0.92 nM1.8 nM
In vitro (25°C) DMSO 100 mg/mL heating (162.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.25 mL 81.25 mL 162.5 mL
0.5 mM 3.25 mL 16.25 mL 32.5 mL
1 mM 1.62 mL 8.12 mL 16.25 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11029
Actions Inhibitor
M. Wt 615.4
Formula C26H23FIN5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 871700-17-3
Synonyms GSK-1120212, GSK212, Trametinib
SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

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