GSK1120212 (JTP-74057, Trametinib)

Catalog No.: A11029

MEK Inhibitor

GSK1120212 (JTP-74057, Trametinib)

GSK1120212 (JTP-74057, Trametinib) Chemical Structure

CAS NO. 871700-17-3

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$60.00
50 mg
$80.00
100 mg
$120.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Kanemaru Y, .et al. Dramatic response of BRAF V600E-mutant epithelioid glioblastoma to combination therapy with BRAF and MEK inhibitor: establishment and xenograft of a cell line to predict clinical efficacy, Acta Neuropathol Commun, 2019, Jul 25;7(1):119 PMID: 31345255
  • Chul Min Park, .et al. Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways, Oncol Lett, 2018, Feb; 15(2): 1758–1762 PMID: 29434871
  • Sumi T, .et al. Trametinib downregulates survivin expression in RB1-positive KRAS-mutant lung adenocarcinoma cells, Biochem Biophys Res Commun, 2018, Jun 18;501(1):253-258 PMID: 29727601
  • Toshiyuki Sumi, .et al. Survivin knockdown induces senescence in TTF-1-expressing, KRAS-mutant lung adenocarcinomas, Int J Oncol, 2018, Jul; 53(1): 33–46 PMID: 29658609
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Yuki Kawasaki, .et al. Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain, Sci Rep, 2016, 6: 31502 PMID: 27531070

Biological Activity

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Targets
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
0.92 nM1.8 nM
In vitro (25°C) DMSO 100 mg/mL heating (162.49 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.25 mL 81.25 mL 162.5 mL
0.5 mM 3.25 mL 16.25 mL 32.5 mL
1 mM 1.62 mL 8.12 mL 16.25 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11029
Actions Inhibitor
M. Wt 615.4
Formula C26H23FIN5O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 871700-17-3
Synonyms GSK-1120212, GSK212, Trametinib
SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

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