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GSK1120212 (JTP-74057, Trametinib)
Catalog No.: A11029
MEK Inhibitor
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Adooq Products cited in reputable paper
Adooq's GSK1120212 (JTP-74057, Trametinib) has been cited by 15 publications
Song Han, .et al. , Neoplasia , 2025, Jan:59:101070 PMID: 39541736 Majid Momeny, .et al. , EMBO Mol Med , 2024, Jun 17 PMID: 38886591 Meenu Kesarwani, .et al. , Blood Adv , 2024, Jun 11;8(11):2765-2776 PMID: 38531054 Saeko Yoshioka, .et al. , Int J Tryptophan Res , 2022, Nov 30;15 PMID: 36467776 Tsung-Ming Chang, .et al. , Journal of Biomedical Science , 2022, 29:92 Nao Yamagishi, .et al. , Biol Pharm Bull , 2022, 45(10):1553-1558 PMID: 36184515 Hayato Mizuta, .et al. , Nat Commun , 2021, Feb 24;12(1):1261 PMID: 33627640 Keisuke Yanagida, .et al. , Dev Cell , 2020, 52 (6), 779-793 PMID: 32059774 Hamzehlou S, .et al. , Eur J Pharmacol , 2019, Nov 15;863:172705 PMID: 31574259 Kanemaru Y, .et al. , Acta Neuropathol Commun , 2019, Jul 25;7(1):119 PMID: 31345255 Chul Min Park, .et al. , Oncol Lett , 2018, Feb; 15(2): 1758-1762 PMID: 29434871 Sumi T, .et al. , Biochem Biophys Res Commun , 2018, Jun 18;501(1):253-258 PMID: 29727601 Toshiyuki Sumi, .et al. , Int J Oncol , 2018, Jul; 53(1): 33-46 PMID: 29658609 Fujita KI, .et al. , J Pharm Sci , 2017, Sep;106(9):2632-2641 PMID: 28479358 Yuki Kawasaki, .et al. , Sci Rep , 2016, 6: 31502 PMID: 27531070
Biological Activity
Discription
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Targets
Solubility
In vitro (25°C)
DMSO
Warmed: 19 mg/mL (30.87 mM)
Water
Insoluble
Ethanol
Insoluble
In vivo
4% DMSO+corn oil
2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass
1 mg
5 mg
10 mg
0.1 mM
16.25 mL
81.25 mL
162.5 mL
0.5 mM
3.25 mL
16.25 mL
32.5 mL
1 mM
1.62 mL
8.12 mL
16.25 mL
5 mM
0.32 mL
1.62 mL
3.25 mL
Useful Calculator
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
* Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1 V1 = C2 V2
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