Total item
Cart Subtotal
$0.00 Biological Activity
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Targets
| MEK1 (Cell-free assay) | MEK2 (Cell-free assay) | |||
| 0.92 nM | 1.8 nM |
| In vitro (25°C) | DMSO | 100 mg/mL heating (162.49 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 15 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.25 mL | 81.25 mL | 162.5 mL |
| 0.5 mM | 3.25 mL | 16.25 mL | 32.5 mL |
| 1 mM | 1.62 mL | 8.12 mL | 16.25 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.25 mL |
*The above data is based on the productmolecular weight 615.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11029 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 615.4 |
| Formula | C26H23FIN5O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 871700-17-3 |
| Synonyms | GSK-1120212, GSK212, Trametinib |
| SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5 |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
RO4927350
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
TAK-733
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
RO4987655
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineopl…
GDC-0973 (Cobimetinib)
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively f…
BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xen…
AS703026 (Pimasertib)
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced oste…
Keywords:buy GSK1120212 (JTP-74057, Trametinib) | GSK1120212 (JTP-74057, Trametinib) Supplier | purchase GSK1120212 (JTP-74057, Trametinib) | GSK1120212 (JTP-74057, Trametinib) cost | GSK1120212 (JTP-74057, Trametinib) manufacturer | order GSK1120212 (JTP-74057, Trametinib) | GSK1120212 (JTP-74057, Trametinib) distributor | buy 871700-17-3| 871700-17-3 Supplier | purchase 871700-17-3 | 871700-17-3 cost | 871700-17-3 manufacturer | order 871700-17-3 | 871700-17-3 distributor
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
Not your Region? View all Distributors
Adooq Quality Guarantee
We promise all products perform as described.