GSK1120212 (JTP-74057, Trametinib)

Name: GSK1120212 (JTP-74057, Trametinib)
SKU: A11029
Price: 25 USD
Rating: 5 (15 reviews)

Catalog No.: A11029

MEK Inhibitor

Adooq's GSK1120212 (JTP-74057, Trametinib) has been cited by 15 publications

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
Size	Price	Stock
5mg	$25.00	In stock
10mg	$45.00	In stock
50mg	$55.00	In stock
100mg	$95.00	In stock
200mg	$135.00	In stock
500mg	$250.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

Bulk Inquiry

Notify me when the price drops

Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Loading distributor info...

Adooq Products cited in reputable paper

Adooq's GSK1120212 (JTP-74057, Trametinib) has been cited by 15 publications

Song Han, .et al. , Neoplasia, 2025, Jan:59:101070 PMID: 39541736

Majid Momeny, .et al. , EMBO Mol Med, 2024, Jun 17 PMID: 38886591

Meenu Kesarwani, .et al. , Blood Adv, 2024, Jun 11;8(11):2765-2776 PMID: 38531054

Saeko Yoshioka, .et al. , Int J Tryptophan Res, 2022, Nov 30;15 PMID: 36467776

Tsung-Ming Chang, .et al. , Journal of Biomedical Science, 2022, 29:92

Nao Yamagishi, .et al. , Biol Pharm Bull, 2022, 45(10):1553-1558 PMID: 36184515

Hayato Mizuta, .et al. , Nat Commun, 2021, Feb 24;12(1):1261 PMID: 33627640

Keisuke Yanagida, .et al. , Dev Cell, 2020, 52 (6), 779-793 PMID: 32059774

Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Kanemaru Y, .et al. , Acta Neuropathol Commun, 2019, Jul 25;7(1):119 PMID: 31345255

Chul Min Park, .et al. , Oncol Lett, 2018, Feb; 15(2): 1758-1762 PMID: 29434871

Sumi T, .et al. , Biochem Biophys Res Commun, 2018, Jun 18;501(1):253-258 PMID: 29727601

Toshiyuki Sumi, .et al. , Int J Oncol, 2018, Jul; 53(1): 33-46 PMID: 29658609

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Yuki Kawasaki, .et al. , Sci Rep, 2016, 6: 31502 PMID: 27531070

Biological Activity

Discription

GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A11029
Formula	C26H23FIN5O4
Molecular Weight	615.4
CAS Number	871700-17-3
SMILES	CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
Synonyms	GSK-1120212, GSK212, Trametinib
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 19 mg/mL (30.87 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.25 mL	81.25 mL	162.5 mL
0.5 mM	3.25 mL	16.25 mL	32.5 mL
1 mM	1.62 mL	8.12 mL	16.25 mL
5 mM	0.32 mL	1.62 mL	3.25 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂