Refametinib

Catalog No.: A11264

MEK inhibitor

Refametinib

Refametinib Chemical Structure

CAS NO. 923032-37-5

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$180.00
50 mg
$300.00
10mM * 1mL in DMSO
$111.00
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Biological Activity

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
Targets
MEK1 MEK2
19 nM47 nM
In vitro DMSO 95 mg/mL (165.98 mM)
Water Insoluble
Ethanol 95 mg/mL (165.98 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.47 mL 87.36 mL 174.72 mL
0.5 mM 3.49 mL 17.47 mL 34.94 mL
1 mM 1.75 mL 8.74 mL 17.47 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11264
Actions Inhibitor
CAS No. 923032-37-5
Formula C19H20F3IN2O5S
M. Wt 572.34
Purity >98%
Synonyms BAY 869766,RDEA119, Bay 86-9766
SMILES COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[[email protected]@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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