Refametinib

Catalog No.: A11264

MEK inhibitor

Refametinib

Refametinib Chemical Structure

CAS NO. 923032-37-5

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Availability: In stock

Package Price Qty
10 mg
$90.00
25 mg
$180.00
50 mg
$300.00
10mM * 1mL in DMSO
$111.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
Targets
MEK1 MEK2
19 nM47 nM
In vitro DMSO 100 mg/mL (174.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 100 mg/mL (174.72 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.47 mL 87.36 mL 174.72 mL
0.5 mM 3.49 mL 17.47 mL 34.94 mL
1 mM 1.75 mL 8.74 mL 17.47 mL
5 mM 0.35 mL 1.75 mL 3.49 mL

*The above data is based on the productmolecular weight 572.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11264
Actions Inhibitor
M. Wt 572.34
Formula C19H20F3IN2O5S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 923032-37-5
Synonyms BAY 869766,RDEA119, Bay 86-9766
SMILES COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[[email protected]@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F

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