Target & Activity
| Target | Activity | Value |
|---|---|---|
| MEK1 | 19 nM | |
| MEK2 | 47 nM |
Fig. 1 · Structure
Documents & Downloads
Refametinib
Cat. No.
A11264
CAS
923032-37-5
MEK inhibitor
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 923032-37-5 |
| Applications | MEK inhibitor |
| Formula | C19H20F3IN2O5S |
| Molecular Weight | 572.34 |
| Synonyms | BAY 869766; RDEA119 |
| SMILES | COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 95 mg/mL (165.98 mM) |
| Water | Insoluble |
| Ethanol | 95 mg/mL (165.98 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.