Refametinib

Name: Refametinib
SKU: A11264
Price: 90 USD
Rating: 5 (288 reviews)

Catalog No.: A11264

MEK inhibitor

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

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Grouped product items
Product Name	Price	Stock
Refametinib 10mg	$90.00	In stock
Refametinib 25mg	$180.00	In stock
Refametinib 50mg	$300.00	In stock
*Refametinib 10mM 1mL in DMSO**	$111.00	In stock
Bulk Size	Bulk Discount

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Data Sheet

SDS

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Biological Activity

Discription

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Targets

Target	Value

Product Information

Catalog Num	A11264
Formula	C19H20F3IN2O5S
Molecular Weight	572.34
CAS Number	923032-37-5
SMILES	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[C@@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F
Synonyms	BAY 869766,RDEA119, Bay 86-9766
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	95 mg/mL (165.98 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (165.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.47 mL	87.36 mL	174.72 mL
0.5 mM	3.49 mL	17.47 mL	34.94 mL
1 mM	1.75 mL	8.74 mL	17.47 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂