Refametinib

Name: Refametinib
Brand: Adooq Bioscience
SKU: A11264
Rating: 100 (268 reviews)

Catalog No.: A11264

MEK inhibitor

Refametinib Chemical Structure

CAS NO. 923032-37-5

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Availability: In stock

Package	Price	Qty
10 mg	$90.00
25 mg	$180.00
50 mg	$300.00
10mM * 1mL in DMSO	$111.00
Custom Size	Get quote

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Biological Activity

Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.

Targets

MEK1	MEK2
19 nM	47 nM

Solubility *

In vitro	DMSO	95 mg/mL (165.98 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (165.98 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.47 mL	87.36 mL	174.72 mL
0.5 mM	3.49 mL	17.47 mL	34.94 mL
1 mM	1.75 mL	8.74 mL	17.47 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

*The above data is based on the productmolecular weight 572.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11264
Actions	Inhibitor
CAS No.	923032-37-5
Formula	C19H20F3IN2O5S
M. Wt	572.34
Purity	>98%
Synonyms	BAY 869766,RDEA119, Bay 86-9766
SMILES	COC1=CC(=C(C(=C1NS(=O)(=O)C2(CC2)C[[email protected]@H](CO)O)NC3=C(C=C(C=C3)I)F)F)F
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.