PD0325901

Catalog No.: A10256

MEK inhibitor

PD0325901

PD0325901 Chemical Structure

CAS NO. 391210-10-9

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.

Availability: In stock

Package Price Qty
5 mg
$45.00
10 mg
$90.00
25 mg
$150.00
100 mg
$310.00
10mM * 1mL in DMSO
$60.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Fukumoto S, .et al. Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27, Acta Histochem, 2018, Feb;120(2):142-150 PMID: 29397960
  • Yoshiteru Yano, .et al. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells, Regenerative Therapy, 2016, 3 (2016) 1-6

Biological Activity

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
Targets
MEK (Cell-free assay)
0.33 nM
In vitro (25°C) DMSO 89 mg/mL (184.57 mM)
Water Insoluble
Ethanol 37 mg/mL (76.73 mM)
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.74 mL 103.69 mL 207.38 mL
0.5 mM 4.15 mL 20.74 mL 41.48 mL
1 mM 2.07 mL 10.37 mL 20.74 mL
5 mM 0.41 mL 2.07 mL 4.15 mL

*The above data is based on the productmolecular weight 482.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10256
Actions Inhibitor
CAS No. 391210-10-9
Formula C16H14F3IN2O4
M. Wt 482.2
Purity >98%
SMILES C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[[email protected]@H](CO)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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