Catalog No.: A10256

MEK inhibitor


PD0325901 Chemical Structure

CAS NO. 391210-10-9

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.

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5 mg
10 mg
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100 mg
10mM * 1mL in DMSO
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  • Jan Langkabel, .et al. Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs, bioRxiv, 2021, January 25
  • Ryan Clarke, .et al. Sequential Activation of Guide RNAs to Enable Successive CRISPR-Cas9 Activities, Mol Cell, 2021, Jan 21;81(2):226-238.e5 PMID: 33378644
  • Tzeng SF, .et al. O-Glycosylation-mediated signaling circuit drives metastatic castration-resistant prostate cancer, FASEB J, 2018, Jun 15:fj201800687 PMID: 29906246
  • Fukumoto S, .et al. Synergistic anti-proliferative effects of mTOR and MEK inhibitors in high-grade chondrosarcoma cell line OUMS-27, Acta Histochem, 2018, Feb;120(2):142-150 PMID: 29397960
  • Yoshiteru Yano, .et al. Non-neural and cardiac differentiating properties of Tbx6-expressing mouse embryonic stem cells, Regenerative Therapy, 2016, 3 (2016) 1-6

Biological Activity

PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
MEK (Cell-free assay)
0.33 nM
In vitro (25°C) DMSO 89 mg/mL (184.57 mM)
Water Insoluble
Ethanol 37 mg/mL (76.73 mM)
In vivo 5%DMSO+40%PEG300+5%Tween80+50%ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.74 mL 103.69 mL 207.38 mL
0.5 mM 4.15 mL 20.74 mL 41.48 mL
1 mM 2.07 mL 10.37 mL 20.74 mL
5 mM 0.41 mL 2.07 mL 4.15 mL

*The above data is based on the productmolecular weight 482.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10256
Actions Inhibitor
CAS No. 391210-10-9
Formula C16H14F3IN2O4
M. Wt 482.2
Purity >98%
SMILES C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOC[[email protected]@H](CO)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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