Total item
Cart Subtotal
$0.00 Details
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Targets
| MEK1 (Cell-free assay) | MEK2 (Cell-free assay) | |||
| 17 nM | 17 nM |
| In vitro (25°C) | DMSO | 96 mg/mL (200.55 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 14 mg/mL (29.24 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.89 mL | 104.45 mL | 208.9 mL |
| 0.5 mM | 4.18 mL | 20.89 mL | 41.78 mL |
| 1 mM | 2.09 mL | 10.44 mL | 20.89 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10212 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 478.7 |
| Formula | C17H14ClF2IN2O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 212631-79-3 |
| Synonyms | CI-1040 |
| SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
RO4927350
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
TAK-733
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
RO4987655
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineopl…
GDC-0973 (Cobimetinib)
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively f…
BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xen…
GSK1120212 (JTP-74057, Trametinib)
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Keywords:buy PD184352 (CI-1040) | PD184352 (CI-1040) Supplier | purchase PD184352 (CI-1040) | PD184352 (CI-1040) cost | PD184352 (CI-1040) manufacturer | order PD184352 (CI-1040) | PD184352 (CI-1040) distributor | buy 212631-79-3| 212631-79-3 Supplier | purchase 212631-79-3 | 212631-79-3 cost | 212631-79-3 manufacturer | order 212631-79-3 | 212631-79-3 distributor
Adooq Quality Guarantee
We promise all products perform as described.