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PD184352 (CI-1040)


MEK1/2 inhibitor

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Catalog No. A10212

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD184352 5mg A10212-5

Regular Price: €38.00

Special Price: €34.20

PD184352 10mg A10212-10

Regular Price: €71.25

Special Price: €64.13

PD184352 25mg A10212-25

Regular Price: €142.50

Special Price: €128.25

PD184352 100mg A10212-100

Regular Price: €399.00

Special Price: €359.10

PD184352 (CI-1040) 10mM * 1mL in DMSO A10212-10mM-D

Regular Price: €92.15

Special Price: €82.94

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

PD184352 (CI-1040)

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Chemical Information

Catalog Num A10212
Actions Inhibitor
M. Wt 478.7
Formula C17H14ClF2IN2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 212631-79-3
Synonyms CI-1040

Biological Activity

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
17 nM17 nM


Solubility (25°C) * In vitro DMSO 96 mg/mL (200.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol 14 mg/mL (29.24 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.89 mL 104.45 mL 208.9mL
0.5 mM 4.18 mL 20.89 mL 41.78 mL
1 mM 2.09 mL 10.44 mL 20.89 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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