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PD184352 (CI-1040)

PD184352 (CI-1040)

Name: PD184352 (CI-1040)
Brand: Adooq Bioscience
SKU: A10212
Rating: 100 (268 reviews)

Catalog No.: A10212

MEK1/2 inhibitor

PD184352 (CI-1040) Chemical Structure

CAS NO. 212631-79-3

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Availability: In stock

Package	Price	Qty
5 mg	$40.00
10 mg	$75.00
25 mg	$150.00
100 mg	$420.00
10mM * 1mL in DMSO	$97.00
Custom Size	Get quote

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Biological Activity

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Targets

MEK1 (Cell-free assay)	MEK2 (Cell-free assay)
17 nM	17 nM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (192.19 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (27.15 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol, pH 9	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.89 mL	104.45 mL	208.9 mL
0.5 mM	4.18 mL	20.89 mL	41.78 mL
1 mM	2.09 mL	10.44 mL	20.89 mL
5 mM	0.42 mL	2.09 mL	4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10212
Actions	Inhibitor
CAS No.	212631-79-3
Formula	C17H14ClF2IN2O2
M. Wt	478.7
Solubility	DMSO
Purity	>98%
Synonyms	CI-1040
SMILES	C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.