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PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Targets
| MEK1 (Cell-free assay) | MEK2 (Cell-free assay) | |||
| 17 nM | 17 nM |
| In vitro (25°C) | DMSO | 96 mg/mL (200.55 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 14 mg/mL (29.24 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.89 mL | 104.45 mL | 208.9 mL |
| 0.5 mM | 4.18 mL | 20.89 mL | 41.78 mL |
| 1 mM | 2.09 mL | 10.44 mL | 20.89 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10212 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 478.7 |
| Formula | C17H14ClF2IN2O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 212631-79-3 |
| Synonyms | CI-1040 |
| SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl |
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