PD184352 (CI-1040)

Catalog No.: A10212

MEK1/2 inhibitor

PD184352 (CI-1040) Chemical Structure

CAS NO. 212631-79-3

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$75.00
25 mg
$150.00
100 mg
$420.00
10mM * 1mL in DMSO
$97.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
Targets
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
17 nM17 nM
In vitro (25°C) DMSO 96 mg/mL (200.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol 14 mg/mL (29.24 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.89 mL 104.45 mL 208.9 mL
0.5 mM 4.18 mL 20.89 mL 41.78 mL
1 mM 2.09 mL 10.44 mL 20.89 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10212
Actions Inhibitor
M. Wt 478.7
Formula C17H14ClF2IN2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 212631-79-3
Synonyms CI-1040
SMILES C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl

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