PD184352 (CI-1040)

PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
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PD184352 5mg
$40.00
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PD184352 10mg
$75.00
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PD184352 25mg
$150.00
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PD184352 100mg
$420.00
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PD184352 (CI-1040) 10mM * 1mL in DMSO
$97.00
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Adooq Products cited in reputable paper
Adooq's PD184352 (CI-1040) has been cited by 2 publications
  • Sachio Suzuki, .et al. , Cell Chem Biol, 2022, Sep 15;29(9):1446-1464 PMID: 35835118
  • Masaru Yoshikawa, .et al. , J Am Chem Soc, 2021, May 5;143(17):6434-6446 PMID: 33890764
  • Biological Activity
    Discription PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
    Targets
    Target Value
    Product Information
    Catalog Num A10212
    Formula C17H14ClF2IN2O2
    Molecular Weight 478.7
    CAS Number 212631-79-3
    SMILES C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 92 mg/mL (192.19 mM)
    Water Insoluble
    Ethanol 13 mg/mL (27.15 mM)
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol, pH 9 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 20.89 mL 104.45 mL 208.9 mL
    0.5 mM 4.18 mL 20.89 mL 41.78 mL
    1 mM 2.09 mL 10.44 mL 20.89 mL
    5 mM 0.42 mL 2.09 mL 4.18 mL
    Useful Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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