BIX02188

Catalog No.: A10150

MEK5 inhibitor

BIX02188

BIX02188 Chemical Structure

CAS NO. 1094614-84-2

BIX02188 is a potent and selective inhibitor of MEK5.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $160.00

Special Price $128.00

50 mg

Regular Price: $450.00

Special Price $360.00

100 mg

Regular Price: $750.00

Special Price $600.00

10mM * 1mL in DMSO
$136.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

BIX02188 is a potent and selective inhibitor of MEK5.
Targets
Target Value
MEK5IC50: 4.3nM
ERK5IC50: 810nM
TGFβR1IC50: 1.8μM
MEK1IC50: >6.3μM
MEK2IC50: >6.3μM
ERK1IC50: >6.3μM
JNK2IC50: >6.3μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM
In vitro (25°C) DMSO 43 mg/mL (104.24 mM)
Water <1 mg/mL (<1 mM)
Ethanol 3 mg/mL (7.27 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.45 mL 117.23 mL 234.47 mL
0.5 mM 4.69 mL 23.45 mL 46.89 mL
1 mM 2.34 mL 11.72 mL 23.45 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

*The above data is based on the productmolecular weight 426.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10150
Actions Inhibitor
M. Wt 426.5
Formula C26H26N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1094614-84-2
Synonyms BIX-02188
SMILES CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4

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