Catalog No.: A10150

MEK5 inhibitor


BIX02188 Chemical Structure

CAS NO. 1094614-84-2, 334949-59-6

BIX02188 is a potent and selective inhibitor of MEK5.

Availability: In stock

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Biological Activity

BIX02188 is a potent and selective inhibitor of MEK5.
Target Value
MEK5IC50: 4.3nM
ERK5IC50: 810nM
TGFβR1IC50: 1.8μM
MEK1IC50: >6.3μM
MEK2IC50: >6.3μM
ERK1IC50: >6.3μM
JNK2IC50: >6.3μM
EGFRIC50: >6.3μM
STK16IC50: >6.3μM
In vitro (25°C) DMSO 39 mg/mL (94.54 mM)
Water Insoluble
Ethanol 3 mg/mL (7.27 mM)
In vivo 5% DMSO+40% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.21 mL 242.42 mL
0.5 mM 4.85 mL 24.24 mL 48.48 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10150
Actions Inhibitor
CAS No. 1094614-84-2, 334949-59-6
Formula C25H24N4O2
M. Wt 412.5
Purity >98%
Synonyms BIX-02188
SMILES CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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