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GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Targets
| MEK1 | ||||
| 0.13 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.92 mL | 109.6 mL | 219.2 mL |
| 0.5 mM | 4.38 mL | 21.92 mL | 43.84 mL |
| 1 mM | 2.19 mL | 10.96 mL | 21.92 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
*The above data is based on the productmolecular weight 456.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12974 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 456.21 |
| Formula | C16H14FIN4O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1168091-68-6 |
| Synonyms | GDC0623, GDC 0632 |
| SMILES | O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO |
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