GDC-0623

Name: GDC-0623
SKU: A12974
Price: 140 USD
Rating: 5 (288 reviews)

Catalog No.: A12974

MEK1 inhibitor

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Notify me when the price drops

Important Notice: For research use only. We do not sell to patients.

Data Sheet

SDS

Contact your local distributors

Not your Region? View all Distributors

Adooq Products cited in reputable paper

Biological Activity

Discription

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

Targets

Target	Value

Chemical Information

Catalog Num	A12974
Formula	C16H14FIN4O3
Molecular Weight	456.21
CAS Number	1168091-68-6
SMILES	O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO
Synonyms	GDC0623, GDC 0632
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 89 mg/mL (195.08 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (10.95 mM)
In vivo	5% DMSO+45% PEG 300+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.92 mL	109.6 mL	219.2 mL
0.5 mM	4.38 mL	21.92 mL	43.84 mL
1 mM	2.19 mL	10.96 mL	21.92 mL
5 mM	0.44 mL	2.19 mL	4.38 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Product Name	Price	Stock
GDC-0623 5mg	$140.00	In stock
GDC-0623 10mg	$250.00	In stock
GDC-0623 25mg	$550.00	In stock