GDC-0623

Catalog No.: A12974

MEK1 inhibitor

GDC-0623

GDC-0623 Chemical Structure

CAS NO. 1168091-68-6

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

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5 mg

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Special Price $112.00

10 mg

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25 mg

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Special Price $440.00

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Biological Activity

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Targets
MEK1
0.13 nM
In vitro (25°C) DMSO Warmed: 89 mg/mL (195.08 mM)
Water Insoluble
Ethanol Warmed: 5 mg/mL (10.95 mM)
In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.92 mL 109.6 mL 219.2 mL
0.5 mM 4.38 mL 21.92 mL 43.84 mL
1 mM 2.19 mL 10.96 mL 21.92 mL
5 mM 0.44 mL 2.19 mL 4.38 mL

*The above data is based on the productmolecular weight 456.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12974
Actions Inhibitor
CAS No. 1168091-68-6
Formula C16H14FIN4O3
M. Wt 456.21
Purity >98%
Synonyms GDC0623, GDC 0632
SMILES O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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