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GDC-0623

GDC-0623

Name: GDC-0623
Brand: Adooq Bioscience
SKU: A12974
Rating: 100 (268 reviews)

Catalog No.: A12974

MEK1 inhibitor

GDC-0623 Chemical Structure

CAS NO. 1168091-68-6

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

Availability: In stock

Package	Price	Qty
5 mg	$140.00
10 mg	$250.00
25 mg	$550.00
Custom Size	Get quote

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Adooq Products cited in reputable paper

Biological Activity

GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.

Targets

MEK1
0.13 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 89 mg/mL (195.08 mM)
	Water	Insoluble
	Ethanol	Warmed: 5 mg/mL (10.95 mM)
In vivo	5% DMSO+45% PEG 300+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.92 mL	109.6 mL	219.2 mL
0.5 mM	4.38 mL	21.92 mL	43.84 mL
1 mM	2.19 mL	10.96 mL	21.92 mL
5 mM	0.44 mL	2.19 mL	4.38 mL

*The above data is based on the productmolecular weight 456.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12974
Actions	Inhibitor
CAS No.	1168091-68-6
Formula	C16H14FIN4O3
M. Wt	456.21
Purity	>98%
Synonyms	GDC0623, GDC 0632
SMILES	O=C(C1=C(NC2=CC=C(I)C=C2F)N3C(C=C1)=CN=C3)NOCCO
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.