Catalog No.: A12974
MEK1 inhibitor
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
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GDC-0623 5mg
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GDC-0623 10mg
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GDC-0623 25mg
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Biological Activity
Discription GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
Target Value
Product Information
Catalog Num A12974
Formula C16H14FIN4O3
Molecular Weight 456.21
CAS Number 1168091-68-6
Synonyms GDC0623, GDC 0632

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro (25°C) DMSO Warmed: 89 mg/mL (195.08 mM)
Water Insoluble
Ethanol Warmed: 5 mg/mL (10.95 mM)
In vivo 5% DMSO+45% PEG 300+ddH2O 19 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.92 mL 109.6 mL 219.2 mL
0.5 mM 4.38 mL 21.92 mL 43.84 mL
1 mM 2.19 mL 10.96 mL 21.92 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
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