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- Anna Nakanishi, .et al. Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model mice, Regen Ther, 2022, Sep 9;21:351-361 PMID: 36161099
- Isamu Ogawa, .et al. Suspension culture of human induced pluripotent stem cell-derived intestinal organoids using natural polysaccharides, Biomaterials, 2022, Sep;288:121696 PMID: 36038421
- Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
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- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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Biological Activity
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
Targets
MEK1 (Cell-free assay) | ||||
2 μM |
In vitro (25°C) | DMSO | Warmed: 13 mg/mL (48.63 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 37.41 mL | 187.06 mL | 374.11 mL |
0.5 mM | 7.48 mL | 37.41 mL | 74.82 mL |
1 mM | 3.74 mL | 18.71 mL | 37.41 mL |
5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
*The above data is based on the productmolecular weight 267.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10705 |
---|---|
Actions | Inhibitor |
CAS No. | 167869-21-8 |
Formula | C16H13NO3 |
M. Wt | 267.3 |
Purity | >98% |
SMILES | COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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