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PD98059

MEK Inhibitor

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Catalog No. A10705

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD98059 10mg A10705-10
€47.50
PD98059 50mg A10705-50
€104.50
PD98059 100mg A10705-100
€180.50
PD98059 200mg A10705-200
€332.50
PD98059 10mM * 1mL in DMSO A10705-10mM-D
€52.25

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.

PD98059

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Publications citing Adooq Products
PD98059 Citations (3)
  • Tsai CC, .et al. Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells, Biochim Biophys Acta Mol Cell Res, 2018, Oct 13. pii: S0167-4889(18)30452-X PMID: 30321617
  • Kim MH, .et al. C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation, Oncol Rep, 2018, Nov;40(5):2977-2987 PMID: 30226616
  • Onozato D, .et al. Efficient Generation of Cynomolgus Monkey Induced Pluripotent Stem Cell-Derived Intestinal Organoids with Pharmacokinetic Functions, Stem Cells Dev, 2018, Aug 1;27(15):1033-1045 PMID: 29742964

Chemical Information

Catalog Num A10705
Actions Inhibitor
M. Wt 267.3
Formula C16H13NO3
Solubility DMSO>32mg/mL Water<1mg/mL Ethanol>3mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 167869-21-8
Synonyms N/A
SMILES code COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
Chemical Name 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Biological Activity

Description
 PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
Targets
MEK1 (Cell-free assay)
2 μM

Solubility

Solubility (25°C) * In vitro DMSO 14 mg/mL heating (52.37 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.41 mL 187.06 mL 374.11mL
0.5 mM 7.48 mL 37.41 mL 74.82 mL
1 mM 3.74 mL 18.71 mL 37.41 mL
5 mM 0.75 mL 3.74 mL 7.48 mL

*The above data is based on the productmolecular weight 267.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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