Catalog No.
Product Name
Application
Product Information
Citations
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AHR Antagonist
CB7993113 is a potent antagonist of the aryl hydrocarbon receptor (AHR), exhibiting an IC50 value of 0.33 μM. This compound effectively binds to the AHR protein and prevents its nuclear translocation, thereby inhibiting the biological effects mediated by this receptor. CB7993113 demonstrates significant inhibitory activity, reducing polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90%, respectively, making it a valuable tool for research into AHR-related signaling pathways and toxicological studies. -
AhR Ligand
10-Cl-BBQ is a high-affinity ligand for the aryl hydrocarbon receptor (AhR), exhibiting significant immunosuppressive activity. This compound facilitates the translocation of AhR from the cytosol to the nucleus and effectively activates AhR-regulated reporter genes at nanomolar concentrations. Its properties make 10-Cl-BBQ a valuable tool for research in immunology and toxicology, particularly in studies focusing on AhR signaling pathways. -
AHR Antagonist
AHR Antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, displaying IC50 values of 885 pM for human AHR and 2.03 nM for mouse AHR. This compound is valuable for investigations into cancer biology and the modulation of immune responses, making it an important tool for research in immunology and oncology. -
AhR Ligand
Benz[a]anthracene is an aromatic hydrocarbon receptor (AhR) ligand, displaying a pIC50 value of 7.319. As a polycyclic aromatic hydrocarbon (PAH), it is important for studies investigating AhR-mediated biological processes and environmental toxicity. This compound is also relevant in assessing pollution impacts, particularly in samples from areas influenced by industrial activities such as aluminum smelting. -
AhR Agonist
Indolokine A5 is a potent AhR (Aryl hydrocarbon receptor) agonist that plays a significant role in various biological processes. This compound is of particular interest in research applications involving immunology, toxicology, and cancer biology, where AhR activation may influence cellular responses and signaling pathways. Its ability to modulate AhR activity makes Indolokine A5 a valuable tool for studying the effects of environmental contaminants and endogenous ligands on cellular function. -
AhR Activator
3-OH-Kynurenamine (dihydroiodide) is an aryl hydrocarbon receptor (AhR) activator that modulates the immune response. It enhances the expression levels of indoleamine 2,3-dioxygenase 1 (Ido1) and transforming growth factor-beta 1 (Tgfb1). Research indicates that it can alleviate skin inflammation in psoriasis mouse models and mitigate kidney damage in nephrotoxic lupus mouse models, making it a valuable tool in studying immune-related conditions. -
AHR Modulator
DiMNF (3',4'-Dimethoxy-αNF) is a selective modulator of the aryl hydrocarbon receptor (AHR). Acting as a competitive ligand with an IC50 of 21 nM, it exhibits antagonistic properties that can be harnessed in anti-inflammatory research. DiMNF is valuable for investigating the role of AHR in various biological processes and potential therapeutic applications. -
AhR Agonist
N-Methylscatole is an aryl hydrocarbon receptor (AhR) agonist known for its ability to activate this important transcription factor. It exhibits weak agonistic activity and no significant antagonistic properties. This compound can be utilized in research involving AhR-mediated pathways and the study of environmental chemicals affecting biological systems. -
AHR Antagonist
AHR Antagonist 5 is a potent aryl hydrocarbon receptor (AHR) antagonist with an IC50 of less than 0.5 μM. This compound effectively inhibits tumor growth, particularly when used in conjunction with the checkpoint inhibitor anti-PD-1. It serves as a valuable tool for research in cancer biology and the development of combination therapies targeting the immune response. -
AhR antagonist
CHD-5 is a potent antagonist of the aryl hydrocarbon receptor (AhR). This compound effectively inhibits AhR-mediated signaling pathways, which are involved in various biological processes including cellular proliferation and immune responses. CHD-5 is valuable for researchers investigating the role of AhR in cancer biology, immunology, and toxicology. -
AhR Agonist
Corannulene is an agonist of the aryl hydrocarbon receptor (AhR), known for its ability to modulate cellular signaling pathways. This compound exhibits reduced cytotoxicity compared to Benzo[a]pyrene in hepatoma cells, making it a valuable tool in cancer research. Corannulene's unique properties may facilitate the exploration of AhR-related mechanisms in tumor biology and therapeutic interventions. -
hCYP1B1 Inhibitor
hCYP1B1-IN-2 is a highly selective inhibitor of the human cytochrome P450 1B1 enzyme (hCYP1B1). It demonstrates remarkable potency in inhibiting hCYP1B1 activity, with an IC50 value of 0.040 nM, alongside a Ki value of 21.71 pM, indicating effective mixed inhibition. This compound also effectively disrupts aryl hydrocarbon receptor (AhR) transcription activities, making it a valuable tool for research applications focused on cancer and toxicology. -
AHR Inhibitor
AHR-IN-1 is a selective aryl hydrocarbon receptor (AHR) inhibitor, exhibiting an IC50 of less than 0.5 μM. This compound is useful for investigating the role of AHR in various biological processes, including immune response modulation and xenobiotic metabolism. AHR-IN-1 serves as a valuable tool for researchers studying the mechanisms by which AHR influences cellular signaling and gene expression. -
AHR Antagonist
AHR Antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist with a 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide structure, exhibiting an IC50 of 82.2 nM. This compound demonstrates significant anti-cancer properties, making it a valuable tool for research on cancer biology and therapeutic applications targeting AHR pathways. Its ability to modulate AHR signaling may offer insights into mechanisms driving tumor progression and potential treatment strategies. -
AhR Agonist
AhR Agonist 8 is a potent agonist of the Aryl Hydrocarbon Receptor (AhR) with an EC50 value of 0.154 nM. This compound serves as a valuable tool for investigating the biological processes linked to psoriasis and atopic dermatitis. Its high affinity and specificity make AhR Agonist 8 suitable for research applications targeting immune modulation and skin-related disorders. -
hCYP1B1 Inhibitor
CYP1B1-IN-10 is a potent and selective inhibitor of human cytochrome P450 1B1 (hCYP1B1), exhibiting an IC50 value of 0.11 μM. This compound plays a significant role in the investigation of hormone-dependent tumors, including breast and ovarian cancers. Its specificity makes it a valuable tool for studying the therapeutic potential in oncology research. -
AhR Agonist
AhR Agonist 6 is a potent agonist for the aryl hydrocarbon receptor (AhR), exhibiting an EC50 of 0.01 nM. This compound effectively activates AhR signaling pathways, making it valuable for investigating the receptor's role in toxicology, immune response, and cellular differentiation processes. Its high potency allows for precise modulation of AhR-related biological activities in various research applications. -
AhR Activator
3-OH-Kynurenamine is an aryl hydrocarbon receptor (AhR) activator that modulates immune responses. This compound enhances the expression of immune regulatory genes such as Ido1 and Tgfb1, demonstrating therapeutic potential in reducing skin inflammation in psoriasis mouse models, as well as alleviating kidney damage in nephrotoxic lupus mouse models. Its unique biological activity makes it valuable for research involving immune modulation and inflammatory diseases. -
AhR Agonist
AhR agonist 7 is a potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 13 nM. This compound effectively activates AhR signaling pathways, making it valuable for research into toxicology, immunology, and cancer biology. AhR agonist 7 can be utilized to study the effects of AhR activation on gene expression and cellular responses. -
AHR Agonis
L-Kynurenine sulfate is an aryl hydrocarbon receptor (AHR) agonist that promotes AHR-mediated signaling pathways. It has been shown to stimulate the polarization of naive T cells towards the anti-inflammatory regulatory T cell (Treg) phenotype, enhancing immune tolerance mechanisms. This compound is valuable for research focused on immunology, inflammation, and therapeutic approaches in autoimmune diseases. -
CYP1A1 Inducer
1,2,3,4,7,8,9-Heptachlorodibenzofuran is a potent inducer of CYP1A1 and CYP1B1 gene expression in human peripheral blood lymphocytes, promoting aryl hydrocarbon receptor repressor (AhRR) transcription. This compound enhances ethoxyresorufin-O-deethylase (EROD) activity, serving as a reliable biomarker for CYP1A1 activation. Additionally, it displays immunosuppressive properties by decreasing the number of splenic plaque-forming cells in mice while increasing aryl hydrocarbon hydroxylase (AHH) activity in liver microsomes. 1,2,3,4,7,8,9-Heptachlorodibenzofuran is valuable for research in immunology, metabolic disorders, and environmental toxicology. -
CYP1A1/1B1 Activator
1,2,3,4,7,8-Hexachlorodibenzofuran is a selective activator of the CYP1A1 and CYP1B1 enzymes. It induces the expression of these cytochrome P450 enzymes and aryl hydrocarbon receptor repressor (AhRR) in human peripheral blood lymphocytes. This compound also stimulates ethoxyresorufin-O-deethylase activity, achieving approximately 20% of the response observed with TCDD at a BMR20TCDD of 0.115-0.143 nM. Its ability to modulate these pathways makes it a valuable tool for studying biological responses to environmental pollutants and the mechanisms of xenobiotic metabolism. -
AHR Activator
AhR modulator-2 is an AHR activator with an EC50 of 0.028 μM in HepG2-Lucia cells. This compound is valuable for investigating the role of the aryl hydrocarbon receptor (AHR) in various diseases, including skin disorders and cancer. Its ability to modulate AHR activity makes it a useful tool in the study of AHR-mediated signaling pathways and associated pathologies. -
Phenylurea Herbicide
Neburon is a phenylurea herbicide that primarily functions by inhibiting photosynthetic electron transport, leading to the disruption of algal growth. This compound activates the aryl hydrocarbon receptor (Ahr) and Notch1 signaling pathways, resulting in the induction of oxidative stress and apoptosis. Prolonged exposure has been associated with significant male reproductive toxicity and cardiotoxicity in zebrafish, making this reagent valuable for studies on environmental impact and toxicological assessments. -
AhR Agonist
Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist that functions at low picomolar concentrations. It is known to inhibit Hedgehog-induced osteoblast differentiation and Wnt3A-induced osteoblast differentiation in C3H10T1/2 cells. Additionally, Picoberin has the ability to upregulate genes responsible for encoding phase I and II metabolic enzymes, making it a valuable reagent for research into cellular differentiation and metabolic processes. -
AHR Antagonist
AHR Antagonist 6 is an aryl hydrocarbon receptor (AHR) antagonist that inhibits AHR signaling pathways. This compound has demonstrated key biological activity in modulating immune responses and is utilized in cancer research to investigate the role of AHR in tumor microenvironments. Researchers can employ AHR Antagonist 6 to explore therapeutic strategies targeting AHR-mediated pathways in various cancer models. -
COX/5-LOX Inhibitor
Phenethyl ferulate is a potent inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), displaying IC50 values of 4.35 μM and 5.75 μM, respectively. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammation-related pathways. Its ability to modulate these key enzymes positions it as a promising candidate for studies focused on inflammatory diseases and therapeutic interventions. -
5-LOX/COX Inhibitor
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), exhibiting IC50 values of 3.5 μM and 3.1 μM, respectively, in RBL-1 cells. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research into inflammatory pathways and related diseases. Its dual inhibition of leukotriene and prostaglandin synthesis positions FPL 62064 as a pertinent reagent for studies focusing on inflammation and related therapeutic interventions. -
Muscarinic Receptor/Phospholipase C Activator
(S)-Albuterol is a selective muscarinic receptor agonist that acts as a phospholipase C activator. It is known to elevate intracellular free calcium levels in airway smooth muscle, enhancing muscle contraction. This compound is widely utilized in research applications focusing on airway physiology and the mechanisms underlying bronchoconstriction. -
Drug metabolite
SCH-720881 is the active metabolite of Rolapitant, a selective and long-acting neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. This compound exhibits significant anti-emetic properties, making it valuable for studies involving nausea and vomiting. SCH-720881 provides insights into the pharmacological effects of NK1 receptor modulation in various preclinical models, thereby facilitating research into anti-emetic therapies. -
Fungal Secondary Metabolite
Benzomalvin B is a fungal secondary metabolite that serves as a less active analog of Benzomalvin A. It exhibits weak activity against substance P, making it a compound of interest for research into neuropeptide signaling and related biological processes. Its properties may facilitate studies in pain modulation and the exploration of therapeutic avenues in neurobiology. -
Endogenous Metabolite
Sorbitol-6-phosphate 2-dehydrogenase from Escherichia coli is a key enzyme that facilitates the conversion of D-sorbitol 6-phosphate to D-fructose 6-phosphate. This dehydrogenase exhibits a significantly faster rate of oxidation of D-sorbitol 6-phosphate, being ten times more efficient than the reduction of D-fructose 6-phosphate. It is vital for various metabolic pathways and cellular processes, making it a valuable reagent for research in metabolic engineering and enzymology studies. -
Endogenous Metabolite
1-1(Z)-Octadecenyl-2-docosahexaenoyl-sn-glycero-3-PE (18:0p/22:6-PE) is an endogenous metabolite that serves as a key structural component in cellular membranes. This lipid, identified in rat brain tissue through mass spectrometry imaging, exhibits unique structural and distribution properties. It has implications in research focused on lipid metabolism and neurobiology, facilitating the exploration of fatty acid chain isomers and their roles in physiological processes. -
Endogenous Metabolite
3-(3-Hydroxyphenyl)-3-hydroxypropanoic acid is an endogenous metabolite identified in urine that plays a significant role in biological processes. It is utilized in research related to autism, aiding in the investigation of metabolic pathways and potential biomarkers. This compound may provide insights into the biochemical alterations associated with neurodevelopmental disorders. -
Endogenous Metabolite
PG 9 maleate is an endogenous metabolite that primarily enhances central cholinergic transmission, resulting in analgesic effects. This compound demonstrates protective activity against memory loss induced by agents such as scopolamine and dicyclomine within a defined dosage range. Notably, PG 9 maleate exhibits significant selectivity for the M4/M1 receptor subtypes, suggesting a potential mechanism underlying its analgesic and neuroprotective properties. Additionally, it promotes acetylcholine release, thereby enhancing its overall biological efficacy. -
PNMT Inhibitor
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 0.3 μM. This compound is primarily utilized in research exploring psychiatric disorders associated with Alzheimer's disease and Parkinson's disease. Its mechanism of action makes it a valuable tool for studying the role of PNMT in neurodegenerative conditions. -
Endogenous Metabolite
Prosulfocarb is an effective herbicide that targets selective weed species in winter cereals. Its primary mechanism involves the inhibition of the biosynthesis of essential fatty acids in plants. This compound is instrumental in managing biotic resistance among weed populations, contributing to more effective agricultural practices. Research applications include studies on environmental impact, residue transfer, and the volatility effects that influence contamination patterns in target and non-target areas. -
Endogenous Metabolite
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a modified phospholipid that serves as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). With an IC50 value of 2 μM at a substrate concentration of 0.5 mM, Thioetheramide-PC interacts with both the catalytic and activation sites of the enzyme, exhibiting tighter binding to the activation site. This unique dual interaction may facilitate phospholipase activation at low concentrations, making Thioetheramide-PC a valuable tool for studying sPLA2-related biological processes and mechanisms. -
Endogenous Metabolite
AZD-3199 is an ultra-long-acting beta2 adrenergic agonist primarily targeting the beta2 adrenergic receptor. It exhibits significant bronchodilator activity, making it a candidate for therapeutic use in asthma and chronic obstructive pulmonary disease (COPD) research. Its prolonged action facilitates investigations into novel treatment strategies for managing these respiratory conditions. -
Endogenous Metabolite
Dabrafenib carboxylic acid is the carboxylate metabolite of dabrafenib, primarily functioning as an endogenous metabolite. This compound retains the capacity to modulate signaling pathways associated with MAPK/ERK pathway alterations. It serves as a valuable tool for studying the pharmacokinetics and biological effects of dabrafenib in cancer research, particularly in the context of melanoma and other tumors with BRAF mutations. -
Endogenous Metabolite
Ranelic acid is an endogenous metabolite with metal cation chelating activity. It plays a vital role in the inhibition of osteoporosis and the enhancement of bone mineral density. Additionally, derivatives of ranelic acid display complex and highly substituted thiophene ring structures, providing potential avenues for further research in bone health and related metabolic pathways. -
Endogenous Metabolite
KBP-5493 is an endogenous metabolite that can be detected in biological fluids such as urine and plasma. This compound plays a significant role in metabolic pathways and may provide insights into various physiological processes. Its detection is essential for research applications in metabolomics and biomarker discovery. -
Fungal Metabolite
Stephacidin B is a fungal metabolite that exhibits significant cytotoxic activity against various human tumor cell lines. Notably, it demonstrates the strongest cytotoxic effects against testosterone-dependent LNCaP prostate cancer cells. This compound can be utilized in cancer research applications to explore therapeutic strategies and mechanisms of action related to prostate cancer. -
Endogenous Metabolite
SU9518 is a selective tyrosine kinase inhibitor targeting PDGFRα, demonstrating significant anti-fibrotic properties. This compound effectively inhibits the progression of proliferative vitreoretinopathy (PVR) in rabbit models involving fibroblasts and Müller cells, showing promising results without discernible toxicity. SU9518 holds potential for therapeutic applications in PVR and other proliferative ocular disorders characterized by fibrosis and gliosis. -
Endogenous Metabolite
PF-05387252 is a potent and selective inhibitor of IRAK4, effectively targeting endogenous Toll-like receptor (TLR) signaling pathways. This compound exhibits significant anti-inflammatory activity in experimental models, suggesting potential therapeutic applications in conditions such as psoriasis. While PF-05387252 has demonstrated efficacy in reducing inflammation in animal studies, its effectiveness in clinical settings for psoriasis has yet to be established. -
Herbicide
Pinoxaden is a selective post-emergence herbicide that targets a wide range of annual grass weeds. As a member of the phenylpyrazolines class, it effectively inhibits specific enzymes involved in the biosynthesis of plant growth regulators, disrupting normal growth processes in target species. Its primary applications include agricultural settings where control of grass weeds is essential for crop management and yield improvement. -
Endogenous Metabolite
Darexaban maleate is a direct factor Xa inhibitor, primarily utilized in the research of venous thromboembolism prevention. Its major metabolite, Darexaban glucitol, exhibits pharmacological activity and is formed in the human liver and intestine via UGT1A9 and UGT1A10-mediated glucitolation. The glucitolation exhibits a K(m) value greater than 250 μM in the liver, while in the intestine, it displays substrate inhibition kinetics with a K(m) of 27.3 μM. The presence of fatty acid-free bovine serum albumin significantly lowers the unbound K(m) values in human liver microsomes and UGT1A9. -
Endogenous Metabolite
13-cis-Vitamin A palmitate is an endogenous metabolite and a geometrical isomer of vitamin A palmitate. Exhibiting approximately 75% of the biological activity of all-trans-vitamins A palmitate, this compound is crucial in various physiological processes, including vision and cellular differentiation. It serves as an important research tool in studies focused on retinoid metabolism and its implications in health and disease. -
Endogenous Metabolite
α-Triglycidyl isocyanurate is an antitumor agent that primarily targets DNA by alkylating and cross-linking its structure, thereby inhibiting DNA replication. This compound demonstrates significant cytotoxic effects and maintains stability in fresh human plasma and whole blood, indicating favorable biocompatibility. Metabolism predominantly occurs in rat liver via an NADPH-independent pathway, and the complexity of its metabolic processes allows for a partial restoration of cytotoxicity under specific conditions. Its properties make α-Triglycidyl isocyanurate a valuable reagent for cancer research and therapeutic studies. -
Endogenous Metabolite
1,3-Dipalmitoyl-2-linoleoylglycerol is a triacylglycerol characterized by the presence of palmitic acid at the sn-1 and sn-3 positions and linoleic acid at the sn-2 position. This compound serves as an endogenous metabolite involved in various biological processes, including cellular signaling and lipid metabolism. It is relevant for research applications focused on lipid biochemistry, metabolism studies, and the exploration of membrane dynamics.
