Catalog No.
Product Name
Application
Product Information
Citations
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Succinate Dehydrogenase Inhibitor
SDH-IN-3 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 of 7.2 μg/mL. This compound exhibits significant antifungal activity against Nigrospora oryzae, with an EC50 of 1.9 μg/mL. SDH-IN-3 is suitable for research applications focused on anti-infection studies and the modulation of metabolic pathways in fungal pathogens. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-3 is a dual inhibitor targeting CYP51 and PD-L1, exhibiting potent antifungal activity with IC50 values of 0.205 μM and 0.039 μM, respectively. This compound induces early apoptosis in fungal cells by reducing levels of intracellular IL-2, NLRP3, and NF-κBp65 proteins. Additionally, CYP51/PD-L1-IN-3 causes mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately resulting in fungal lysis and cell death. This compound serves as a valuable tool for research in fungal infections and immune modulation. -
Succinate Dehydrogenase Inhibitor
Harzianopyridone is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 80 nM. Isolated from the fungus Trichoderma harzianum, this compound demonstrates significant antifungal, antibacterial, and herbicidal properties. Harzianopyridone is valuable for research applications exploring metabolic modulation and the study of fungal and bacterial pathways. -
Antifungal Agent/LOX-1 Inhibitor
Sclerotiorin is a reversible uncompetitive inhibitor of soybean lipoxygenase-1 (LOX-1), with an IC50 value of 4.2 μM. This compound exhibits significant antioxidant activity by scavenging free radicals (ED50: 0.12 μM) and inhibiting nonenzymatic lipid peroxidation. Additionally, Sclerotiorin demonstrates antifungal properties and the ability to inhibit platelet aggregation. It can be isolated from the fermented broth of Penicillium frequentans, making it a valuable reagent for research in antifungal mechanisms and oxidative stress studies. -
VEGFR-2/DHFR Inhibitor
VEGFR-2/DHFR-IN-2 is a dual inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) and Dihydrofolate Reductase (DHFR), exhibiting IC50 values of 0.623 μM and 9.085 μM, respectively. This compound demonstrates significant cytotoxic activity against various cancer cell lines, including C26, HepG2, and MCF7, with IC50 values ranging from 3.59 to 8.38 μM. VEGFR-2/DHFR-IN-2 is pertinent for research applications focused on cancer therapeutics and targeted inhibition of tumor angiogenesis. -
DHFR Inhibitor
DHFR-IN-1 is a selective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 40.71 nM. This compound demonstrates significant antibacterial activity against both gram-positive and gram-negative bacteria, as well as moderate antifungal properties. Additionally, DHFR-IN-1 exhibits a strong synergistic effect when combined with Levofloxacin, characterized by a fractional inhibitory concentration index (FIC) value of 0.249, making it a valuable candidate for further research in antimicrobial applications. -
Endogenous Metabolite
Citaldoxime is an endogenous metabolite recognized for its role as a γ-radiation-induced antifungal stress metabolite found in Citrus plants. This compound exhibits notable antifungal activity, making it valuable for studies focused on plant stress responses and fungal pathogen interactions. Research applications include investigating metabolic responses to environmental stressors and exploring potential antifungal mechanisms in plant systems. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-2 is a quinazoline compound that functions as a dual inhibitor of CYP51 and PD-L1, exhibiting IC50 values of 0.263 μM and 0.017 μM, respectively. It displays notable antifungal activity by triggering early apoptosis in fungal cells, leading to significant reductions in intracellular IL-2, NLRP3, and NF-κBp65 protein levels. Additionally, CYP51/PD-L1-IN-2 induces mitochondrial damage and reactive oxygen species (ROS) accumulation, culminating in fungal lysis and subsequent cell death. This compound is valuable for research exploring antifungal mechanisms and cancer immunotherapy. -
VEGFR-2/DHFR Inhibitor
VEGFR-2/DHFR-IN-1 is a dual inhibitor of VEGFR-2 and dihydrofolate reductase (DHFR), exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. This compound demonstrates significant antibacterial activity against various strains, including Escherichia coli and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, VEGFR-2/DHFR-IN-1 shows potent cytotoxic effects on cancer cell lines C26, HepG2, and MCF7, with IC50 values between 2.97 and 7.12 μM. This reagent is applicable for research exploring cancer therapeutics and microbial resistance. -
Succinate Dehydrogenase Inhibitor
Succinate dehydrogenase-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH). This indene amino acid derivative exhibits significant antifungal activity in vitro, with effective concentrations against Rhizoctonia solani (EC50=0.1843 mg/L), Botrytis cinerea (EC50=0.4829 mg/L), and Sclerotinia sclerotiorum (EC50=0.1349 mg/L). It is a valuable tool for research applications focused on inhibiting SDH in microbial pathogens. -
Fungal Metabolite
Viridiol is a fungal metabolite derived from Trichoderma viride, primarily exhibiting antifungal properties. This compound demonstrates efficacy against various fungal pathogens, making it a valuable tool for research into fungal biology and antifungal drug development. Its applications include investigating mechanisms of antifungal resistance and exploring potential therapeutic strategies for fungal infections. -
CYP51/PD-L1 Inhibitor
CYP51/PD-L1-IN-1 is a dual inhibitor targeting both CYP51 and PD-L1, exhibiting an IC50 of 0.884 μM for CYP51 and 0.083 μM for PD-L1. This quinazoline compound demonstrates notable antifungal activity by inducing early apoptosis in fungal cells while significantly reducing intracellular levels of IL-2, NLRP3, and NF-κBp65. Additionally, CYP51/PD-L1-IN-1 contributes to mitochondrial damage and reactive oxygen species (ROS) accumulation, ultimately leading to fungal lysis and cell death. This compound is valuable for research focused on antifungal therapies and immune modulation. -
Antifungal Metabolite
Eucalyptacid A is an antifungal metabolite that demonstrates significant antifungal activity against Alternaria solani, with minimum inhibitory concentration (MIC) values ranging from 6.25 to 50 μM. This compound is suitable for research applications focused on antifungal mechanisms and studying phytopathogen interactions. Its effectiveness positions it as a valuable tool for investigating potential antifungal treatments in agricultural and biomedical research. -
Succinate Dehydrogenase Inhibitor
SDH-IN-8 is a potent inhibitor of succinate dehydrogenase (SDH), demonstrating an IC50 value of 27 nM in porcine SDH assays. This compound exhibits significant fungicidal activity, making it a valuable tool for investigating the role of SDH in fungal metabolism and potential therapeutic applications in fungal infections. Researchers may utilize SDH-IN-8 to explore mechanisms of SDH inhibition and its effects on cellular respiration and metabolic pathways. -
Antifungal Metabolite
Chaetosemin J is an antifungal metabolite with demonstrated inhibitory activity against several plant pathogenic fungi, including Botrytis cinerea, Alternaria solani, Magnaporthe oryzae, and Gibberella saubinettii. Its minimum inhibitory concentration (MIC) values range from 12.5 to 25 μM, indicating its potential utility in agricultural research and studies aimed at developing new antifungal agents. -
Antifungal Metabolite
Canadensolide is an antifungal metabolite derived from Penicillium canadense. It exhibits potent antifungal activity against various pathogenic fungi, making it valuable for studying fungal infections and developing antifungal strategies. Research applications include investigating mechanisms of action in fungal resistance and exploring potential therapeutic uses in clinical settings. -
Fungal Metabolite
dl-Aloesol is a natural fungal metabolite derived from Aspergillus species, primarily known for its diverse biological activities. It exhibits cytotoxic, antibacterial, anti-parasitic, antiviral, and antiproliferative properties, making it a valuable tool for research applications in microbiology, pharmacology, and medicinal chemistry. Its ability to scavenge free radicals further underscores its potential in studies focused on oxidative stress and cellular protection. -
CYP51 Inhibitor
CYP51-IN-19 is a potent inhibitor of cytochrome P450 51 (CYP51), a critical enzyme involved in sterol biosynthesis in fungi. This compound induces the generation of reactive oxygen species (ROS), leading to significant fungicidal activity. It is primarily utilized in antifungal research and the development of therapeutic agents targeting fungal infections. -
Carbonic Anhydrase Probe
(+)-Xylariamide A is a potent probe for carbonic anhydrases, specifically targeting the β-carbonic anhydrases found in mycobacterial and fungal pathogens. It demonstrates significant inhibitory activity, making it a valuable tool for studying the role of carbonic anhydrases in microbial physiology and pathogenicity. Research applications include investigating antifungal and antibacterial mechanisms, as well as exploring therapeutic strategies against resistant strains. -
Herbicide
Triclopyr is a foliar systemic herbicide primarily targeting broadleaf and woody plants. It disrupts plant growth by mimicking natural plant hormones, leading to uncontrolled growth and eventual plant death. This compound is essential in research applications focused on invasive species management and ecosystem restoration. Due to its potent biological activity, caution is advised when handling Triclopyr. -
Fungal Metabolite
Homogentisic acid lactone is a fungal metabolite that exhibits significant fungicidal activity, notably against the plant pathogenic fungus Fusarium graminearum. This compound is derived from the fungus WF5 and serves as a valuable substrate for assessing serum paraoxonase/arylesterase 1 (PON1) activity in biochemical research. Its unique mode of action and biological properties make it an important tool in studies related to fungal pathogenesis and enzyme activity assessment. -
Succinate Dehydrogenase Inhibitor
Isofetamid is a potent inhibitor of succinate dehydrogenase, primarily utilized as a fungicide. It demonstrates effective control against a range of fungal pathogens, including gray mold, white mold, and powdery mildew. This compound is valuable for research related to plant fungal diseases, contributing to the understanding of fungal inhibition mechanisms and disease management strategies. -
Anti-inflammation/Infection Agent
β-Amyrone is a triterpene compound recognized for its anti-inflammatory properties, primarily through the inhibition of cyclooxygenase-2 (COX-2) expression. It demonstrates significant antifungal activity and exhibits antiviral effects against the Chikungunya virus. Additionally, β-Amyrone inhibits α-glucosidase and acetylcholinesterase (AChE) activities, making it a valuable compound for research in inflammation, infectious diseases, and obesity-related studies. -
Fungicide and Herbicide
Akardite II is a nitrocellulose stabilizer that functions as a scavenger for nitrogen oxides (NOx). It exhibits broad-spectrum biological activity as both a fungicide and herbicide, effectively controlling various plant pathogens and weeds. Akardite II is utilized in agricultural research applications aimed at enhancing crop protection and increasing yield by mitigating unwanted flora and fungal infections. -
Antifungal Agent
Eleutherol is a naphthalene derivative derived from E. americana, exhibiting significant antifungal properties. It effectively targets various yeast species, including Candida albicans, C. tropicalis, Saccharomyces cerevisiae, and Cryptococcus neoformans, with minimum inhibitory concentration (MIC) values ranging from 7.8 µg/mL to 250 µg/mL. Additionally, Eleutherol inhibits α-glucosidase activity, presenting an IC50 greater than 1.00 mM, indicating its potential for further research in antifungal applications and enzyme inhibition studies. -
Sulfonylurea Herbicide, Photosynthetic System Inhibitor, Acetolactate Synthase (ALS) Inhibitor, Branched-chain Amino Acids (BCAAs) Inhibitor
Nicosulfuron is a selective sulfonylurea herbicide that acts as an inhibitor of acetolactate synthase (ALS) within the photosynthetic system. It effectively disrupts the synthesis of branched-chain amino acids (BCAAs), which is beneficial for maize cultivation by enhancing adaptability through glycolysis and the tricarboxylic acid cycle. Additionally, Nicosulfuron demonstrates antifungal properties and its degradation is dependent on glucose concentration when interacting with Plectosphaerella cucumerina AR1 in a planktonic environment. This compound is widely used in agricultural research for studying herbicide efficacy and metabolic pathways. -
FAAH/MAGL Inhibitor
1-Monomyristin serves as a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), with IC50 values of 18 μM and 32 μM, respectively. It effectively inhibits the hydrolysis of 2-oleoylglycerol via MAGL, exhibiting antibacterial and antifungal activities against pathogens such as Staphylococcus aureus, Aggregatibacter actinomycetemcomitans, and Candida albicans. Additionally, 1-Monomyristin demonstrates lethality to brine shrimp and shows marginal cytotoxicity against prostate cancer cells. This reagent is suitable for research focused on bacterial and fungal infections, as well as various cancer types, including renal cancer, prostate adenocarcinoma, and pancreatic cancer. -
Fungal CYP51 Inhibitor
VT-1598 is an orally active and selective inhibitor of fungal cytochrome P450 51 (CYP51). It exhibits potent antifungal activity against Candida auris, making it a valuable tool for research into fungal infections. Additionally, VT-1598 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications, facilitating the study of various biological interactions. -
Fungal Metabolite
Cladosporin is a fungal metabolite with potent antibiotic and antifungal properties. It demonstrates significant inhibitory activity against a range of dermatophytes, plant pathogens, and bacteria. Additionally, Cladosporin exhibits antimalarial effects by targeting cytoplasmic lysine-tRNA synthetase in Plasmodium (PfKrs1), making it a valuable compound for research in microbial resistance and antimalarial studies. -
Bacterial Inhibitor
5,6-Dihydroxyindole is a bacterial inhibitor known for its broad-spectrum antibacterial, antifungal, antiviral, and antiparasitic activities. As a precursor in melanin synthesis, it exhibits cytotoxic properties, demonstrating significant toxicity against a variety of pathogenic organisms. This compound is valuable for research applications focused on antimicrobial resistance and the development of novel therapeutic agents. -
MAO Inhibitor
Phenelzine sulfate is an irreversible, orally active monoamine oxidase (MAO-A and MAO-B) inhibitor, primarily utilized as an antidepressant agent. It enhances levels of neurotransmitters, including serotonin, norepinephrine, and dopamine, while inhibiting GABA transaminase and primary amine oxidase, and sequestering reactive aldehydes. Additionally, Phenelzine sulfate suppresses oxidative stress and lipogenesis and inhibits LSD1 (Ki: 5.6 μM). Its applications extend across research into neurological, metabolic, and oncological diseases, particularly in the context of depression, anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson's disease, Alzheimer's disease, inflammatory pain, obesity, and prostate cancer. -
EGFR/HER2/DHFR Inhibitor
EGFR/HER2/DHFR-IN-1 is a selective inhibitor targeting the epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and dihydrofolate reductase (DHFR). This compound demonstrates potent antitumor efficacy, with IC50 values of 0.153 μM for EGFR, 0.108 μM for HER2, and 0.291 μM for DHFR. EGFR/HER2/DHFR-IN-1 effectively arrests the cell cycle at the G1/S phase and promotes apoptosis in MCF-7 breast cancer cells, making it a valuable reagent for cancer research and therapeutic development. -
DHFR Inhibitor
DHFR-IN-4 is a potent inhibitor of dihydrofolate reductase (DHFR) with an IC50 value of 123 nM. In addition to its primary activity, DHFR-IN-4 exhibits inhibitory effects on epidermal growth factor receptor (EGFR) and HER2, with IC50 values of 246 nM and 357 nM, respectively. This compound demonstrates significant cytotoxic potency across a broad spectrum of cancer cell lines, making it a valuable tool for cancer research and drug development. -
HSP90/EGFR Inhibitor
Wighteone, a prenylated isoflavone, acts as an HSP90 and EGFR inhibitor, specifically targeting the EGFR L858R/T790M mutations. This compound effectively reduces HSP90 expression, inhibits EGF-induced phosphorylation of EGFR, and disrupts downstream signaling through ERK and AKT pathways. Wighteone demonstrates significant biological activity by inducing cell cycle redistribution, inhibiting proliferation, and triggering apoptosis in various cancer cell lines. It is relevant for research on HER2-positive breast cancer, leukemia, non-small cell lung cancer with specific mutations, and also displays antifungal properties. -
PPAR Inhibitor
AZ0108 is a selective inhibitor of poly(ADP-ribose) polymerases (PARPs), including PARP1, PARP2, PARP3, PARP6, TNKS1, and TNKS2. It displays potent inhibitory activity with IC50 values of <0.03 μM for PARP1 and PARP2, and exhibits significant biological effects such as preventing centrosome clustering with an EC50 of 0.053 μM. Additionally, AZ0108 demonstrates cytotoxicity in OCI-LY-19 cells, with a GI50 value of 0.017 μM, and shows favorable pharmacokinetic properties in rat and mouse models, making it a valuable tool for cellular and molecular biology research focused on DNA repair and cancer therapeutic studies. -
Poly(ADP-ribose) Synthetase Inhibitor
2-Methylquinazolin-4-ol is a potent competitive inhibitor of poly(ADP-ribose) synthetase, exhibiting a Ki value of 1.1 μM. Additionally, it functions as an inhibitor of mammalian aspartate transcarbamylase (ATCase) with an IC50 of 0.20 mM. This compound has significant applications in research focused on cellular stress responses, DNA repair mechanisms, and metabolic regulation. -
PPAR-1 Inhibitor
AZD-9574-acid is a selective PPAR-1 inhibitor that serves as a crucial building block for the development of PROTAC molecules. Its inhibition of PPAR-1 demonstrates significant potential in the regulation of metabolic pathways and inflammatory responses. This compound is essential for researchers exploring targeted protein degradation and its applications in therapeutic development. -
Endogenous Metabolite
Purine, an endogenous metabolite, serves as a fundamental building block of nucleic acids. It plays a role in inhibiting the activation of poly(ADP-ribose) polymerase (PARP) and provides protection against oxidant-induced cellular injury. Purine is utilized in research related to cancer and neurological disorders, highlighting its significance in studying cellular processes and treatments for various diseases. -
MAO Inhibitor
Tranylcypromine-d5 hydrochloride is a deuterium-labeled derivative of the irreversible, nonselective monoamine oxidase (MAO) inhibitor, Tranylcypromine. It exhibits potent antidepressant activity by inhibiting MAO, thereby increasing levels of neurotransmitters such as serotonin and norepinephrine in the brain. Additionally, this compound has been identified as a lysine-specific demethylase 1 (LSD1) inhibitor, demonstrating efficacy in reducing lesion growth and alleviating generalized hyperalgesia in mouse models of induced endometriosis. It serves as a valuable tool in neurological and pain research applications. -
HSP90/LSD1 Inhibitor
HSP90/LSD1-IN-1 is a dual inhibitor targeting HSP90 and LSD1, effectively disrupting their interaction and function. This compound demonstrates significant antiproliferative activity in prostate cancer cell lines, exhibiting GI50 values of 0.24 μM for PC-3 and 0.30 μM for DU145. It is a valuable tool for research into therapeutic strategies against prostate cancer and the role of chaperone proteins and histone demethylases in tumor biology. -
Endogenous Metabolite
α-Hydroxyglutaric acid is an endogenous metabolite that acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET enzyme family responsible for converting 5-methylcytosine (5mC) to hydroxymethylcytosine (5hmC). This compound is instrumental in epigenetic research, influencing histone modification and DNA methylation processes. Its role in metabolic pathways also makes it valuable for studying glioma metabolism and hypoxia-related conditions. -
Autophagy Inducer
Loperamide hydrochloride is an opioid receptor agonist that functions primarily as an autophagy inducer. This compound selectively inhibits human intestinal carboxylesterases (hiCE), contributing to its anti-diarrheal properties. Its unique mechanism of action makes Loperamide hydrochloride a valuable reagent for studies related to gastrointestinal motility and autophagy modulation in various biological contexts. -
Hsp90 Inhibitor
PU24FCl is a selective inhibitor of the heat shock protein 90 (Hsp90). This compound demonstrates significant anti-cancer activity, promoting tumor regression by disrupting chaperone activity critical for the stability and function of multiple oncogenic clients. Notably, PU24FCl selectively accumulates in tumor tissues while being rapidly eliminated from normal tissues, enhancing its therapeutic potential in cancer research applications. -
Endogenous Metabolite
Homovanillic acid, a key metabolite of dopamine, serves as an important biomarker in various neurological and metabolic disorders. Elevated or altered levels of homovanillic acid have been implicated in conditions such as aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency. This compound is valuable for research applications focused on neurochemistry and metabolic diseases, enabling the study of dopamine metabolism and related pathologies. -
MAO-B Inhibitor
Desmethoxyyangonin is a selective inhibitor of monoamine oxidase B (MAO-B), with an IC50 value of 0.123 µM. This kavalactone, derived from the Piper methysticum plant, exhibits notable anti-inflammatory properties through the inhibition of Jak2/STAT3 and IKK signaling pathways. Additionally, Desmethoxyyangonin plays a role in inducing CYP3A23 expression and contributes to skeletal muscle relaxation, making it a valuable tool for research in neuropharmacology and inflammation. -
PPAR Activator
Alpinetin is a flavonoid that acts as a PPAR-γ activator, demonstrating significant anti-inflammatory and hepatoprotective properties. It effectively inhibits lipopolysaccharide (LPS)-induced inflammation and protects against LPS-induced renal injury by modulating TLR4 expression and activating the Nrf2 pathway. Its diverse biological activities make Alpinetin a valuable reagent for research into tumor biology, cardiovascular health, and neuroprotection. -
Partial PPARγ Agonist
Oroxin A is a partial agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It enhances PPARγ transcriptional activity through binding to the PPARγ ligand-binding domain. Additionally, Oroxin A demonstrates inhibitory effects on α-glucosidase and possesses antioxidant properties. Its anti-breast cancer potential is attributed to the induction of endoplasmic reticulum stress-mediated cellular senescence, making it a valuable tool for research in metabolic and cancer biology. -
PPAR Activator
Angeloylgomisin H is a PPAR-γ activator derived from the lignin extract of Schisandra rubriflora. This compound has demonstrated the ability to enhance insulin-stimulated glucose uptake, making it a valuable candidate for research in metabolic disorders and diabetes. Its mechanism of action may provide insights into therapeutic strategies aimed at improving insulin sensitivity and glucose metabolism. -
PDE IV Inhibitor/A1AR Antagonist
Doxofylline is an orally active phosphodiesterase IV (PDE IV) inhibitor and adenosine A1 receptor (A1AR) antagonist. It exhibits anti-inflammatory properties by reducing mitochondrial reactive oxygen species (ROS) production and modulating various cellular pathways, including the NLRP3-TXNIP inflammasome activation. This compound is valuable for research related to respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and bronchospasm. -
PDE Inhibitor
Flavoxate hydrochloride is a competitive inhibitor of phosphodiesterase (PDE), providing significant antispasmodic effects through its action as a muscarinic acetylcholine receptor (mAChR) antagonist. In addition to its PDE inhibition, it exhibits moderate calcium antagonistic properties and local anesthetic effects. Flavoxate hydrochloride is utilized in research focused on overactive bladder (OAB) and related lower urinary tract infections, contributing to a better understanding of these conditions and potential therapeutic approaches.
