Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
Palmitoleic acid sodium is an endogenous metabolite that plays a crucial role in lipid metabolism and cell signaling. This fatty acid has been shown to possess potential neuroprotective effects, particularly in the context of cerebrovascular disorders. It is utilized in research for its ability to modulate inflammatory pathways and support cardiovascular health, making it a valuable tool for studies related to metabolic disease and stroke prevention. -
Endogenous Metabolite
Atrazine mercapturate is an endogenous metabolite of the herbicide Atrazine, detectable in urinary samples. This compound serves as a reliable biomarker for confirming human exposure to Atrazine, facilitating research into its environmental and health impacts. Its detection is critical for studies on herbicide metabolism and toxicity in various populations. -
Endogenous Metabolite
Circumdatin A is an endogenous metabolite isolated from a fungal culture, characterized through detailed NMR spectral analysis. It exhibits potential biological activities that are currently being investigated in various research applications, particularly in the fields of biochemistry and natural product chemistry. Its unique structural attributes may contribute to understanding metabolic pathways and fungal biosynthesis. -
Endogenous Metabolite
(S)-3,4-Dihydroxybutyric acid sodium is an endogenous metabolite primarily associated with the metabolism of gamma-aminobutyric acid (GABA). It is notably excreted at elevated levels in individuals with succinic semialdehyde dehydrogenase (SSADH) deficiency. This compound serves as a valuable biomarker for diagnostic research and metabolic studies related to GABAergic dysfunction and neurological disorders. -
Endogenous Metabolite
PMPMEase-IN-2 is an inhibitor of polyprenylated protein methylesterase, targeting the regulation of polyprenylated protein metabolism. This regulation is crucial for maintaining normal cellular function and survival, with dysregulation linked to degenerative diseases and cancer. PMPMEase-IN-2 holds potential applications in cancer research, providing a specific approach for investigating the modulation of polyprenylated protein pathways. -
Endogenous Metabolite
Uridine 5'-triphosphate tris salt acts primarily as an endogenous metabolite involved in cellular energy transfer and nucleotide synthesis. It plays critical roles in RNA synthesis and is essential for various biochemical pathways, including signal transduction and cellular metabolism. This reagent is widely utilized in research applications such as studying nucleoside triphosphate dynamics and investigating metabolic processes in cell biology. -
Endogenous Metabolite
Triflusulfuron-methyl is a selective herbicide that acts by inhibiting the enzyme acetolactate synthase (ALS), which is crucial for the biosynthesis of branched-chain amino acids. It demonstrates significant biological activity in controlling specific weed species by disrupting their growth and development. This compound is commonly used in agricultural research to study herbicide resistance mechanisms and assess crop safety against ALS inhibitors. -
Endogenous Metabolite
Moperone hydrochloride is a selective antagonist of the dopamine D2 receptor. It demonstrates significant biological activity in modulating dopaminergic neurotransmission, making it valuable in the research of psychiatric disorders such as schizophrenia and other dopamine-related conditions. This compound is essential for studies aimed at understanding the role of dopamine in mental health and the development of antipsychotic therapies. -
Endogenous Metabolite
sEH-IN-12 is a potent inhibitor of soluble epoxide hydrolase (sEH) that effectively blocks its activity. This compound demonstrates strong biological activity and has been utilized in the construction and selection of small molecule libraries. The development of sEH-IN-12 offers a valuable tool for drug discovery efforts aimed at targeting sEH for therapeutic interventions. -
Fungal Metabolite
Aculene A is a norsesquiterpene derived from the fungus Aspergillus aculeatus, primarily targeting fungal metabolic pathways. It exhibits significant biological activity, making it valuable for research applications in mycology and natural product studies. Aculene A may serve as a lead compound for investigating fungal interactions and the development of antifungal agents. -
Endogenous Metabolite
Neogen, also known as Jadinol PU, is an endogenous metabolite that plays a crucial role in immune system restoration and hematopoiesis. It demonstrates significant activity in supporting the recovery of immune functions following cytotoxic treatments. This compound is particularly useful in research focused on improving outcomes for patients undergoing chemotherapy. -
Endogenous Metabolite
Antiarrhythmic agent-3 is an endogenous metabolite that enhances the efficacy of antiarrhythmic treatments while improving the inhibition index. Its antiarrhythmic properties are associated with its hydrophobicity, reflected in its log P value. Additionally, its potential central nervous system toxicity is linked to the interplay between its hydrophobic characteristics and acid constant (pKa). This compound is primarily utilized in research related to cardiac rhythm management and toxicity studies. -
Endogenous Metabolite
12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies. -
Endogenous Metabolite
(2R)-Pasireotide (diaspartate) is a potent somatostatin analog with a primary mechanism of action targeting somatostatin receptor 5 (SST5). It demonstrates a 40-fold higher affinity for SST5 compared to other somatostatin analogs, making it a valuable tool for studying somatostatin signaling pathways. This compound is primarily used in research applications focused on neuroendocrine tumors and other conditions influenced by somatostatin receptor activity. -
Endogenous Metabolite
C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is an endogenous metabolite characterized by a long-chain fatty acid (24:1) linked to a 1-deoxysphingoid backbone. This lipid molecule accumulates in conditions such as obesity and type 2 diabetes, contributing to cellular toxicity due to its inability to be further metabolized into complex sphingolipids. Research applications include studies of lipid metabolism, obesity, and the pathophysiology of metabolic disorders, particularly in differentiated adipocytes. -
Endogenous Metabolite
5-trans Prostaglandin F2α is an endogenous metabolite with a significant role in cardiovascular physiology. It is primarily involved in the modulation of vascular tone and plays a critical role in inflammatory responses. This compound is essential for researching myocardial infarction and other cardiovascular disorders as it provides insights into the underlying metabolic and physiological mechanisms. -
Endogenous Metabolite
Propane-1,2,3-triyl tritricosanoate is a triacylglycerol that serves as an internal standard for the quantification of fatty acids. It contains tricosanoic acid at all three acyl positions and has applications in studying the triglyceride component of human aortic endothelial cells (HAECs) cultured in media supplemented with stearic and/or oleic acid. This reagent is essential for accurately assessing lipid metabolism and fatty acid composition in complex biological systems. -
Endogenous Metabolite
4,7,10,13,16-Docosapentaenoic acid is an endogenous metabolite that plays a crucial role in cellular signaling and lipid metabolism. Its biological activity includes anti-inflammatory properties and modulation of oxidative stress. This compound is valuable in research focusing on metabolic disorders, cardiovascular diseases, and inflammation-related studies. -
Endogenous Metabolite
SKF 106760 is a potent antagonist of the platelet fibrin receptor glycoprotein IIb/IIIa, demonstrating significant antiplatelet and antithrombotic activities. This compound effectively inhibits platelet aggregation in vitro and prevents thrombus formation within stenotic carotid arteries. Additionally, SKF 106760 exhibits efficacy against aspirin-resistant thrombi that occur in high-grade stenosis conditions, making it a valuable tool for investigating antithrombotic therapies in cardiovascular research. -
pheromone
(Z)-6-Heneicosen-11-one is a naturally occurring pheromone primarily isolated from the moth species Orgyia detrit. This compound plays a crucial role in insect communication and mating behaviors, making it valuable for studies in entomology and chemical ecology. Its unique properties can be utilized in research applications focused on behavioral assays and the study of pheromone signaling pathways in various organisms. -
Endogenous Metabolite
5,7-Dihydroxy-11-ketotetranorprostanoic acid is an endogenous metabolite of prostaglandin F2α, serving as a precursor to tetranor-PGF metabolites. This compound plays a significant role in various biological pathways related to prostaglandin metabolism. While it exhibits minimal activity in blood pressure and smooth muscle stimulation assays, it is valuable for research in prostaglandin-related studies and urinary metabolite profiling. -
Fungal Metabolite
7-Hydroxypestalotin is a fungal metabolite known for its ability to modulate biological pathways. This compound exhibits significant antifungal activity, making it a valuable tool in the study of fungal biology and pathogen resistance. Its unique properties can be utilized in various research applications, including the development of antifungal agents and the exploration of fungal metabolism. -
Endogenous Metabolite
Inosine oxime is an endogenous metabolite that plays a role in cellular metabolism, primarily generated through the activity of cytochrome P450, oxidative stress, or altered nucleotide biosynthesis. This compound exhibits toxic and mutagenic effects in both prokaryotic and eukaryotic cells, making it a valuable tool for research into cellular responses to stress and mutagenesis. Its utility extends to studies investigating metabolic pathways and the impact of metabolites on cellular function. -
Endogenous Metabolite
Roxatidine hydrochloride is an anti-ulcer agent that primarily targets the inhibition of gastric acid secretion. This compound effectively prevents the formation of duodenal and gastric ulcers while alleviating ulcer-related pain. With a favorable safety profile, Roxatidine hydrochloride demonstrates effective therapeutic potential even at lower doses compared to similar agents, making it a valuable tool for gastroenterological research. -
Endogenous Metabolite
BCM-599 is an endogenous metabolite that functions as a hepatitis B virus (HBV) capsid assembly inhibitor. It demonstrates potent antiviral activity with an IC50 value of 0.88 μM and a CC50 value of 144 μM in HepG2.2.15 cells. When administered in conjunction with lamivudine, BCM-599 exhibits a synergistic effect, enhancing the reduction of viral concentration. This compound is a valuable tool for investigating combined strategies for the treatment of HBV infection. -
Endogenous Metabolite
Mannose 1-phosphate is an endogenous metabolite that serves as a critical precursor in glycosylation pathways. It participates in the synthesis of GDP-mannose via the action of the enzyme GDP-mannose pyrophosphorylase. This compound is integral for research applications focusing on glycoprotein biosynthesis and metabolic pathways involving mannose derivatives. -
Endogenous Metabolite
Trimoxamine hydrochloride is an antihypertensive agent that functions primarily by inhibiting vasoconstriction, leading to a reduction in blood pressure. This compound is valuable for the management of hypertension-related diseases and cardiovascular disorders. Its primary mechanism as an endogenous metabolite underlines its potential role in clinical and research applications targeting cardiovascular health. -
Endogenous Metabolite
Sabiporide mesylate is a selective inhibitor of sodium-hydrogen exchange, primarily targeting NHE1. This compound exhibits cardioprotective properties, rendering it an important reagent for studies on myocardial ischemia and myocardial infarction. Its ability to modulate sodium and hydrogen ion transport makes it useful in exploring cellular mechanisms linked to cardiac stress responses. -
Endogenous Metabolite
4-Amino-L-phenylalanine hydrochloride is an endogenous metabolite that serves as a precursor in various biochemical pathways. Its biological activity includes modulation of neurotransmitter synthesis and regulation of metabolic processes. This compound is primarily utilized in research involving amino acid metabolism, neurobiology, and the broader study of physiological functions related to phenylalanine derivatives. -
Endogenous Metabolite
Ethylenediaminediacetic acid (EDDA) serves as a key ligand, effectively enhancing the antiproliferative activities of metal complexes. These complexes demonstrate significant antiproliferative effects in the MCF-7 cancer cell line and exhibit the capacity to interact with DNA, as analyzed through circular dichroism (CD) and electron paramagnetic resonance (EPR) spectroscopy. Additionally, EDDA and its metal complexes can induce cell cycle arrest at the G(0)/G(1) phase, highlighting their potential application in cancer research. Structural analysis of EDDA contributes valuable insights into its biological mechanisms and interactions. -
Endogenous Metabolite
MIPS1455 is a light-activated ligand that targets the M1 muscarinic acetylcholine receptor, exhibiting irreversible binding at the allosteric site. This compound demonstrates significant potential in modulating receptor activity, with applications in researching cognitive deficits and allosteric interactions. MIPS1455 may serve as a valuable molecular tool for further exploration of receptor pharmacology and related therapeutic implications. -
Endogenous Metabolite
AZD-6605 is a potent, reversible inhibitor targeting matrix metalloproteinases MMP2, MMP9, MMP12, and MMP13, exhibiting high selectivity. This compound was optimized for enhanced activity, solubility, and drug metabolism and pharmacokinetics (DMPK) properties by modifying the zinc hydroxide binding group found in traditional inhibitors. AZD-6605 is valuable for investigating the roles of these metalloproteinases in various biological processes and disease states, making it suitable for research applications in inflammation, cancer, and tissue remodeling studies. -
Endogenous Metabolite
1,2-Distearoyl-3-arachidoyl-rac-glycerol is an endogenous metabolite involved in the study of triglyceride composition, particularly in bovine milk fat. This compound has been identified and quantified through various analytical methods, contributing to a better understanding of lipid profiles in dairy research. Its applications extend to investigations into lipid metabolism and the nutritional properties of milk-derived products. -
Endogenous Metabolite
Cinosulfuron is a selective herbicide that targets specific enzyme activity to effectively inhibit a range of broadleaf weeds. Its use in agricultural practices enhances crop yield and quality by managing weed infestations, thereby promoting optimal growth conditions for desirable plants. This compound serves as a crucial tool in effective farmland management and sustainable agriculture. -
Endogenous Metabolite
A-62198 is a selective renin inhibitor that exhibits significant antihypertensive properties. It effectively reduces mean arterial pressure (MAP) in anesthetized, salt-deprived primate models in a dose-dependent manner. Notably, A-62198 also demonstrates a statistically significant decrease in plasma renin activity (PRA) across all administered doses, making it a valuable tool for research in cardiovascular pharmacology and hypertension studies. -
Endogenous Metabolite
NSC-84096 is an endopeptidase activity inhibitor that effectively inhibits the enzymatic activity of botulinum neurotoxin type A light chain (rBoNT/A-LC). Its ability to block this neurotoxin in vitro suggests a significant potential for use in research focused on botulism and related neurotoxic disorders. The mechanism of action for NSC-84096 may facilitate the development of small molecule therapeutics targeting these hazardous toxins. -
Endogenous Metabolite
Deoxygerfelin, an endogenous metabolite derived from A. versicolor, exhibits significant phenolic antioxidant properties. It effectively scavenges free radicals, demonstrated through its activity in Trolox equivalent antioxidant capacity (TEAC) assays. This compound can be utilized in research applications aimed at studying oxidative stress and its effects on cellular processes. -
Endogenous Metabolite
p18SMI-21 is an innovative inhibitor targeting the INK4C protein, effectively blocking the biological activity of p18. This compound exhibits a significant reduction in the proteolytic activity of pepsin, demonstrating its potential as an anti-gastric acid agent. Its inhibitory efficacy is notably influenced by dosing and requires direct contact with the substrate to maintain its effect. p18SMI-21 is valuable for researchers investigating gastric acid dynamics and the regulatory mechanisms of p18 in cellular metabolism. -
Endogenous Metabolite
Gletimbetasin is a thymosin β4 analog that functions primarily as an endogenous metabolite. This compound exhibits notable anti-inflammatory activity, making it a valuable tool for investigating the molecular mechanisms underlying inflammation. Its applications extend to studies focused on wound healing, tissue regeneration, and cellular responses to stress, providing insights into potential therapeutic strategies for inflammatory diseases. -
Endogenous Metabolite
(5aS,6R,6aR)-MK-8666 functions as a selective agonist of the GPR40 receptor, primarily targeting pancreatic β cells and intestinal enteroendocrine cells to enhance fatty acid-induced insulin secretion. This compound has been investigated for its potential in the treatment of type 2 diabetes, demonstrating significant reductions in blood glucose levels. Despite its therapeutic promise, development ceased during Phase I clinical trials due to concerns regarding liver safety. -
Endogenous Metabolite
PSI 352707 is an endogenous metabolite of sofosbuvir, functioning as an antiviral compound. It demonstrates significant activity against chronic hepatitis C virus infections, exhibiting favorable safety and tolerability profiles. PSI 352707 is utilized in research related to antiviral drug mechanisms and hepatitis C treatment strategies. -
Endogenous Metabolite
Pemetrexed tromethamine (dihydrochloric) dihydrate is an endogenous metabolite targeting folate metabolism, primarily utilized as a chemotherapeutic agent. It exhibits potent anti-cancer activity, making it effective in the treatment of pleural mesothelioma and non-small cell lung cancer. This compound is instrumental in cancer research, particularly in studies focused on folate pathway inhibitors and their therapeutic implications. -
Endogenous Metabolite
7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde. -
Endogenous Metabolites
8-Iso-15-keto prostaglandin F2β is an endogenous metabolite derived from 8-Iso PGF2β through the 15-hydroxy-PG dehydrogenase pathway. This compound is known to exhibit vasoconstrictive properties in pulmonary veins, particularly in canine and porcine models. It serves as a valuable tool for investigating the physiological roles of prostaglandins and their metabolites in cardiovascular research. -
Endogenous Metabolite
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite primarily found in cerebrospinal fluid. This compound serves as a valuable tool in the investigation of Parkinson's Disease, aiding in the understanding of its biochemical pathways and potential therapeutic targets. Its presence and activity in neurobiological contexts make it significant for research aimed at elucidating the mechanisms underlying neurodegenerative disorders. -
Endogenous Metabolite
AVE-8063 hydrochloride is an endogenous metabolite that modulates inflammatory responses, making it relevant for research in inflammatory bowel disease (IBD). This compound exhibits potential therapeutic mechanisms that can enhance precision targeting in contemporary treatment strategies for IBD. Its application in scientific studies may contribute to a better understanding of the inflammatory processes involved in gastrointestinal disorders. -
Endogenous Metabolite
(-)-Carveol is a natural unsaturated monocyclic monoterpene alcohol known for its ability to regulate neural excitability. This compound can modulate neural activity through structural changes, making it significant for the development of targeted therapeutic agents. Additionally, (-)-Carveol serves roles as a fragrance in cosmetic applications and as a flavor additive in the food industry, highlighting its versatility in various research contexts. -
Endogenous Metabolite
11-Deoxyprostaglandin F2β is an endogenous metabolite that serves as an analog of PGF2β, generated through the cyclooxygenase metabolism of arachidonic acid. This compound is known to induce a dose-dependent release of hexose-containing mucin, making it useful in research related to mucin secretion and related physiological processes. It is applicable in studies investigating inflammatory responses and the modulation of lipid signaling pathways. -
Endogenous Metabolite
C16 1-Deoxyceramide (m18:1/16:0) is an endogenous metabolite that serves as a lipid molecule characterized by a long-chain fatty acid (16:0) linked to a 1-deoxysphingoid backbone. This compound has been shown to accumulate in conditions such as obesity and type 2 diabetes, where it is toxic due to its inability to be further metabolized into more complex sphingolipids. Research indicates that C16 1-Deoxyceramide levels increase in differentiated adipocytes, suggesting its potential role in metabolic disorders and lipid signaling pathways. -
Endogenous Metabolite
Tiracizine hydrochloride is an endogenous metabolite identified as a Class I antiarrhythmic agent, primarily targeting myocardial function. It exhibits a significant reduction in myocardial contractility, making it relevant for research into ischemic heart disease and related cardiac conditions. This compound may prove beneficial for understanding mechanisms underlying heart disease management and the assessment of cardiac function.
