Catalog No.
Product Name
Application
Product Information
Citations
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PDE5 Inhibitor
Vardenafil hydrochloride trihydrate is a selective and orally active phosphodiesterase-5 (PDE5) inhibitor, exhibiting an IC50 of 0.7 nM. It also demonstrates inhibitory effects on PDE1 and PDE6 with IC50 values of 180 nM and 11 nM, respectively, while showing minimal activity against PDE3 and PDE4 (IC50s >1000 nM). By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil hydrochloride trihydrate elevates cGMP levels. This compound is primarily utilized in research related to erectile dysfunction as well as conditions such as hepatitis and diabetes. -
Endogenous Metabolite
Spermine is an endogenous metabolite known for its antioxidant and anti-inflammatory properties. It exhibits inhibitory effects on certain bacterial strains, particularly Staphylococcus aureus, and induces neurotoxicity in a dose-dependent manner in striatal cells. Additionally, spermine can reversibly inhibit DNA synthesis, mixed lymphocyte responses, and cytolytic lymphocyte induction in murine spleen cell cultures. Spermine tetrahydrochloride serves as a nitric oxide donor, modulating platelet activation in a concentration-dependent manner, while also demonstrating inhibitory effects on primary human embryo lung fibroblasts in vitro. -
PDE3/PDE4/PDE5/HRH1 Inhibitor
Fenspiride hydrochloride is a non-steroidal anti-inflammatory agent and an antagonist of the H1-histamine receptor. It selectively inhibits phosphodiesterase activities, including PDE3, PDE4, and PDE5, with -log IC50 values of 3.44, 4.16, and approximately 3.8, respectively. This compound is valuable for research applications focused on respiratory diseases, highlighting its potential in therapeutic investigations and the modulation of inflammatory responses. -
Carbonic Anhydrase Inhibitor
Fluorometholone acetate is a synthetic glucocorticoid corticosteroid that functions as a potent inhibitor of carbonic anhydrase (CA). It displays inhibition with IC50 values of 2.18 μM for human carbonic anhydrase I (hCA-I) and 17.5 μM for human carbonic anhydrase II (hCA-II). This compound exhibits significant anti-inflammatory properties, making it valuable for research in external ocular inflammation and related therapeutic applications. -
PDE Inhibitor
Pentoxifylline is a non-selective phosphodiesterase (PDE) inhibitor with significant haemorheological properties. It exhibits immune modulation, anti-inflammatory, anti-fibrinolytic, and anti-proliferative activities, making it a valuable tool in biomedical research. Pentoxifylline is particularly applicable in studies of peripheral vascular disease, cerebrovascular disease, and other conditions associated with impaired regional microcirculation. -
Rare Aldopentose
D-Arabinopyranose is a rare aldo-pentose that serves as a precursor to D-arabinose in its open-chain form. This compound exhibits significant biological activity, including antidepressant effects and growth inhibition in Caenorhabditis elegans with an IC50 of 7.5 mM. D-Arabinose penetrates the blood-brain barrier, specifically modulating the metabolism of D-ribose and D-fructose, while also demonstrating antibacterial properties by inhibiting biofilm synthesis. Additionally, it activates the ACSS2-PPARγ/TFEB-CRTC1 axis via the lysosomal AXIN-LKB1-AMPK pathway, leading to antidepressant-like outcomes. -
HMG-CoA Reductase (HMGCR) Inhibitor
Pravastatin is a competitive inhibitor of HMG-CoA reductase (HMGCR), playing a critical role in the regulation of cholesterol biosynthesis. With an IC50 value of 5.6 μM, it effectively reduces cholesterol levels and is commonly utilized in cardiovascular research. This compound is valuable for studies investigating lipid metabolism and the pharmacological modulation of cholesterol levels in various biological systems. -
Hydrocholeretic Agent
Dehydrocholic acid sodium is a hydrocholeretic agent that enhances bile production and secretion. It possesses the ability to modulate autophagy, decrease serum levels of amylase and lipase, protect hepatic function, and regulate cholesterol metabolism. This compound is particularly relevant for research on acute biliary pancreatitis and obstructive jaundice, providing insights into its potential therapeutic benefits in liver and pancreatic disorders. -
Endogenous Metabolite
D-Glucuronic acid is an endogenous metabolite that plays a crucial role in the synthesis of anti-inflammatory proteoglycans. It is implicated in promoting embryonic development and inhibiting cell aggregation. This compound can be metabolized to ethyl glucuronide, which activates Toll-like receptor 4 (TLR4), associated with pain signaling. D-Glucuronic acid and its derivative glucurono-lactone are recognized for their potential as liver detoxifiers and exhibit anti-tumor activity, making them important tools in various biological research applications. -
Endogenous Metabolite
Spermine tetrahydrochloride is a polyamine that serves as a nitric oxide donor, modulating platelet activation in a concentration-dependent manner. This endogenous metabolite exhibits a range of biological activities, including antioxidant and anti-inflammatory properties, and demonstrates inhibitory effects on primary human embryo lung fibroblasts in vitro. Additionally, spermine influences immune responses by reversibly inhibiting DNA synthesis and lymphocyte activation in murine spleen cell cultures. Its antibacterial properties include inhibition of certain bacterial strains, notably Staphylococcus aureus, while also eliciting neurotoxic effects in the striatum in a dose-dependent fashion. -
PDE5 Inhibitor
Vardenafil hydrochloride is a selective phosphodiesterase-5 (PDE5) inhibitor, exhibiting an IC50 of 0.7 nM. This compound demonstrates moderate inhibition of PDE1 and PDE6, with IC50 values of 180 nM and 11 nM, respectively, while showing minimal activity against PDE3 and PDE4. By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil hydrochloride effectively elevates cGMP levels. It serves as a valuable tool in research related to erectile dysfunction, hepatitis, and diabetes. -
CYP3A4 Inhibitor
Escholtzine perchlorate is a potent CYP3A4 inhibitor derived from the alkaloid Eschscholzia californica. This compound demonstrates significant biological activity, with an IC50 value for CYP3A4 of 13.4 μM and an EC50 value for the 5-HT1A receptor of 11 μM. Escholtzine perchlorate is primarily utilized in research focused on anxiety and depression, offering valuable insights into pharmacological mechanisms related to these conditions. -
5-HT6R/MAO-B Inhibitor
5-HT6R/MAO-B modulator 1 is a selective antagonist of the 5-HT6 receptor with Gs signaling activity and serves as an irreversible inhibitor of monoamine oxidase B (MAO-B). This compound demonstrates glioprotective effects and has the capability to reverse memory deficits induced by scopolamine. Additionally, it features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, making it a versatile tool for chemical biology applications. -
Hsp90 Inhibitor
Conglobatin is a macrolide dilactone that functions as an Hsp90 inhibitor. It selectively binds to the N-terminal domain of Hsp90, effectively disrupting the Hsp90-Cdc37 complex formation. This compound demonstrates significant apoptotic activity in human breast cancer cells and esophageal squamous cell carcinoma cells, and it exhibits notable antitumor efficacy in vivo, making it a potential candidate for cancer research applications. -
Herbicide
Fomesafen is an orally active herbicide that primarily targets protoporphyrinogen oxidase (PPO). This compound is effective in inducing apoptosis and increasing reactive oxygen species (ROS), which contributes to its herbicidal activity. In addition to its application in managing broadleaf weeds in soybean fields, rubber plantations, and orchards, it has been associated with developmental toxicity, immunotoxicity, and neurotoxicity, as well as the induction of precancerous lesions and hepato-porphyria in murine models. -
Endogenous Metabolite
D-Glucaric acid tetrahydrate is an endogenous metabolite that serves as an important product of the mammalian D-glucuronidation pathway. This compound exhibits notable biological activities, including the induction of apoptosis and the reduction of expression of myelin-related genes in the hippocampus, such as Mbp and Plp1. Additionally, D-Glucaric acid tetrahydrate demonstrates cholesterol-lowering and anti-tumor properties, making it relevant for research applications in neurological diseases and cancer biology. -
Herbicide
Glyphosate-13C2,15N is a stable isotope-labeled derivative of glyphosate, an herbicide that specifically inhibits the shikimate pathway, crucial for the biosynthesis of aromatic amino acids in plants. This compound is used in research to study the metabolic processes in plants and assess the environmental fate of glyphosate. Its isotopic labeling allows for precise tracking and analysis in various experimental settings, enhancing understanding of herbicide behavior and plant interactions. -
Enpp/Carbonic Anhydrase Inhibitor
Enpp/Carbonic anhydrase-IN-2 is a potent inhibitor of ecto-nucleotide pyrophosphatase/phosphodiesterase (Enpp) and carbonic anhydrases, exhibiting IC50 values of 1.13 µM for NPP1, 1.07 µM for NPP2, 0.74 µM for NPP3, 0.33 µM for CA-IX, and 0.68 µM for CA-XII. This compound demonstrates significant antiproliferative effects on cancer cells while maintaining low cytotoxicity toward normal cell lines. Additionally, Enpp/Carbonic anhydrase-IN-2 has been shown to induce apoptosis, making it a valuable tool for cancer biology research and therapeutic development. -
PPARγ Agonist
Ankaflavin is an orally active peroxisome proliferator-activated receptor gamma (PPARγ) agonist, derived from Monascus-fermented red rice. This compound demonstrates selective cytotoxicity in cancer cells, inducing apoptosis and facilitating cell death. Additionally, Ankaflavin exhibits notable anti-inflammatory, anti-cancer, anti-atherosclerotic, and hypolipidemic properties, making it useful for various research applications in cancer biology and metabolic disorders. -
15-lipoxygenase Inhibitor
4-MMPB is a selective inhibitor of 15-lipoxygenase, exhibiting an IC50 of 18 μM. It demonstrates competitive inhibition with IC50 values of 19.5 μM for soybean 15-lipoxygenase and 19.1 μM for human 15-lipoxygenase-1. This compound may hold promise for research applications focused on prostate cancer, providing insights into the role of 15-lipoxygenase in tumor biology. -
HMG-CoA Reductase Inhibitor
Pitavastatin sodium is a potent inhibitor of hydroxymethylglutaryl-CoA (HMG-CoA) reductase, significantly reducing cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. This compound serves as an effective inducer of low-density lipoprotein-cholesterol (LDL-C) receptors in hepatocytes. In addition to its primary role in cholesterol regulation, pitavastatin sodium exhibits various biological activities, including anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective, and reno-protective effects, making it valuable for diverse research applications in lipid metabolism and disease. -
Anti-inflammatory Agent
(-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that serves as an anti-inflammatory agent through the inhibition of α-glucosidase. This compound exhibits hypoglycemic properties and demonstrates chemopreventive potential by inducing apoptosis and causing G2/M phase cell cycle arrest. Its biological activities make it a valuable tool for research in inflammation and metabolic disorders. -
IDO1/TrxR1 Inhibitor
ZC0109 is a potent dual inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1), exhibiting IC50 values of 50 nM and 3.0 μM, respectively. This compound is effective in inducing reactive oxygen species (ROS) accumulation and causing cell cycle arrest at the G1/S phase, ultimately leading to apoptosis in cancer cells. ZC0109 is a valuable reagent for research applications focused on cancer therapy and the modulation of immune response through IDO1 and TrxR1 inhibition. -
5-Lipoxygenase Inhibitor
CNB-001 is a potent inhibitor of 5-lipoxygenase (5-LOX), demonstrating strong oral bioavailability. This compound effectively reduces 5-LOX expression and enhances proteasome activity, leading to the inhibition of soluble Amyloid-β accumulation and ubiquitinated protein aggregates. It also exhibits neuroprotective properties by inhibiting apoptosis and reactive oxygen species (ROS) production while stabilizing mitochondrial membrane potential. Additionally, CNB-001 addresses insulin resistance and enhances glucose uptake, making it valuable for research into inflammation, neurological disorders, and metabolic diseases such as Alzheimer's disease, stroke, and diabetes. -
CypA Inhibitor
HL001 is an oral small molecule inhibitor targeting Cyclophilin A (CypA) and acting as a receptor antagonist for Lysophosphatidic acid 1 (LPA1). This compound induces cell cycle arrest and apoptosis in tumor cells via p53 stabilization, achieved by down-regulating G3BP1 and promoting reactive oxygen species production and DNA damage. HL001 disrupts the MDM2-p53-72R interaction in a CypA-dependent manner, demonstrating significant antitumor activity. Additionally, HL001 serves as a valuable tool in the investigation of pulmonary fibrosis. -
PDE3A Modulator
Nauclefine is an indole alkaloid derived from Nauclea officinalis, serving as a modulator of phosphodiesterase 3A (PDE3A). This compound has been shown to promote apoptosis in cancer cells via a PDE3A-SLFN12-dependent death pathway. Its biological activity makes Nauclefine a valuable tool for research into cancer therapeutics and the understanding of apoptotic mechanisms. -
Cathepsin Inhibitor
TS-24 is a selective inhibitor of cathepsin S, demonstrating an IC50 value of 4.3 μM. This compound has been shown to exhibit radiosensitizing effects in wild-type BRCA1 and triple-negative breast cancer (TNBC) xenograft models, primarily by inducing apoptotic pathways. TS-24 is suitable for research applications focused on cancer therapeutic development and understanding cathepsin-mediated biological processes. -
α-Glucosidase Inhibitor
Malabaricone B is a naturally occurring phenolic compound that functions as an α-glucosidase inhibitor, exhibiting an IC50 of 63.7 µM. This compound demonstrates significant biological activities, including anticancer, antimicrobial, antioxidant, and antidiabetic effects. It is suitable for research applications focused on metabolic regulation and the investigation of glycemic control. -
Phospholipase A2 Inhibitor
(2E)-OBAA is a selective inhibitor of phospholipase A2 (PLA2) with an IC50 value of 70 nM. This compound effectively induces apoptosis in human umbilical vein endothelial cells (HUVECs) and demonstrates its capacity to inhibit melittin-induced Ca2+ influx in Trypanosoma brucei, exhibiting an IC50 of 0.4 μM. (2E)-OBAA is valuable for research focused on cell signaling, apoptosis, and parasitology. -
PPARγ Inhibtior
Perfluorotetradecanoic acid (PFTeDA) is a potent PPARγ inhibitor, demonstrating a binding affinity to the human PPARγ ligand-binding domain with an IC50 of 22.8 μM and a Kd of 157.8 μM. It has been shown to impair Leydig cell function through the induction of oxidative stress and apoptosis. Additionally, PFTeDA stimulates corticosterone biosynthesis while inhibiting aldosterone production, making it a valuable tool for researching steroidogenesis and related metabolic pathways. -
Phospholipase D Inhibitor
PLD-IN-1 is a selective inhibitor of phospholipase D, exhibiting an IC50 of 1.97 μM. This compound reduces the expression of immune evasion markers such as CD24, CD47, and PD-L1 while promoting calreticulin, thereby enhancing phagocytosis of lung cancer cells by macrophages. PLD-IN-1 demonstrates significant cytotoxic effects on various lung cancer cell lines, including A549, HCC44, H460, and HCC15, with IC50 values ranging from 18.44 to 24.85 μM. Additionally, it induces apoptosis, inhibits cell migration, enhances M1 macrophage polarization, and exhibits antitumor efficacy in mouse models, making it a valuable tool for cancer research. -
IDO-1/NS2B-NS3 Inhibitor
Palmatine is a selective, irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO-1), exhibiting IC50 values of 3 μM against HEK 293-hIDO-1 and 157 μM against rhIDO-1. Additionally, Palmatine effectively inhibits the West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. This compound demonstrates diverse biological activities including anti-cancer, anti-oxidation, anti-inflammatory, neuroprotective, antibacterial, and antiviral effects, making it a valuable tool for research in cancer biology, inflammation, and infectious diseases. -
Ahr Agonist
AHR Agonist 3 is a potent agonist of the aryl hydrocarbon receptor (AhR) that induces cell cycle arrest and apoptosis by activating tumor-suppressive transcriptional programs. It effectively inhibits the growth of stem cells in triple-negative breast cancer (TNBC) while demonstrating low cytotoxicity towards normal human primary cells. This compound is a valuable tool for cancer research, particularly in studies focused on TNBC and the mechanisms underlying AhR-mediated signaling pathways. -
Enpp/Carbonic Anhydrase Inhibitor
Enpp/Carbonic Anhydrase-IN-1 is a potent inhibitor of ecto-nucleotide triphosphate diphosphohydrolase (ENPP) and carbonic anhydrase, exhibiting IC50 values of 1.36 μM for NPP1, 1.35 μM for NPP2, 3.00 μM for NPP3, 0.88 μM for CA-II, and 1.02 μM for CA-IX. This compound demonstrates significant antiproliferative effects on cancer cells while displaying low cytotoxicity to normal cells. Additionally, Enpp/Carbonic Anhydrase-IN-1 has been shown to induce apoptosis, making it a valuable tool for cancer research and therapeutic investigations. -
Carbonic Anhydrase Inhibitor
Zonisamide sodium is a potent carbonic anhydrase inhibitor, effectively targeting hCA II and hCA V with Kis of 35.2 nM and 20.6 nM, respectively. This compound exhibits neuroprotective properties by promoting anti-apoptotic mechanisms and enhancing the expression of manganese superoxide dismutase (MnSOD). Additionally, Zonisamide sodium has been shown to upregulate Hrd1, contributing to improved cardiac function in animal models of cardiac hypertrophy. Its diverse biological activities make it suitable for investigations related to seizures, Parkinson's disease, and cardiovascular research. -
HSP90/mTOR Inhibitor
HSP90/mTOR-IN-1 is a potent inhibitor targeting both Hsp90 and mTOR, exhibiting IC50 values of 69 nM and 29 nM, respectively. This compound effectively suppresses the proliferation of SW780 cells by over-activating the PI3K/AKT/mTOR signaling pathway. In addition to inducing apoptosis and autophagy through selective inhibition, HSP90/mTOR-IN-1 demonstrates significant in vivo anti-tumor activity. It serves as a valuable reagent for research applications focused on bladder cancer. -
PAI-1 Inhibitor
TM5441 sodium is a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1), demonstrating IC50 values ranging from 13.9 to 51.1 μM. It has been shown to induce intrinsic apoptosis in various human cancer cell lines, making it a valuable tool in cancer research. Additionally, TM5441 sodium mitigates cardiac hypertension and vascular senescence induced by Nω-nitro-l-arginine methyl ester, suggesting potential therapeutic applications in cardiovascular studies. -
Antitumor
3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor known for its antitumor properties. It effectively induces apoptosis in tumor cells, contributing to its potential as a therapeutic agent in cancer research. Additionally, 3-Hydroxybakuchiol exhibits moderate inhibitory activity against α-glucosidase, with an IC50 value of 345 μM, further expanding its applications in biological studies. -
Carbonic Anhydrase Inhibitor
hCAIX/XII-IN-5 is a selective inhibitor of carbonic anhydrases IX and XII, demonstrating Ki values of 93.9 nM and 85.7 nM, respectively. This compound exhibits notable anti-proliferative effects on cancer cells, leading to cell cycle delay and the induction of apoptosis. hCAIX/XII-IN-5 is a valuable tool for elucidating the roles of carbonic anhydrases in cancer biology and for developing targeted therapeutic strategies. -
PPARγ Ligand
CAY10506 is a potent ligand of peroxisome proliferator-activated receptor gamma (PPARγ) that induces cell death and reactive oxygen species (ROS) production through a PPARγ-dependent mechanism. This compound demonstrates radiosensitizing properties, enhancing apoptosis induced by gamma radiation and facilitating caspase-3-mediated cleavage of poly (ADP-ribose) polymerase (PARP). CAY10506 is applicable in cancer research, particularly in studies focused on PPARγ signaling pathways and radiation therapy augmentation. -
NAMPT Inhibitor
(E/Z)-Daporinad hydrochloride is a potent inhibitor of nicotinamide phosphoribose transferase (NAMPT). By specifically targeting NAMPT, this compound induces apoptosis through the gradual depletion of intracellular NAD+. (E/Z)-Daporinad hydrochloride is utilized in research to explore mechanisms in cancer biology and inflammatory diseases. -
IDO/Tubulin Inhibitor
IDO/Tubulin-IN-2 is a potent inhibitor targeting both indoleamine 2,3-dioxygenase (IDO) and tubulin. This compound exhibits significant anticancer activity, demonstrated by its effect on various cell lines, including U87, HepG2, A549, HCT-116, and LO2, with IC50 values of 0.43, 0.036, 0.041, 0.095, and 1.04 μM, respectively. IDO/Tubulin-IN-2 is valuable for research applications in cancer biology, particularly in elucidating mechanisms of tumorigenesis and therapeutic resistance. -
PDE1 Inhibitor
PDE1-IN-6 is a selective phosphodiesterase 1 (PDE1) inhibitor with an IC50 of 7.5 nM. It effectively inhibits cell proliferation and induces apoptosis in acute myelogenous leukemia (AML) cells. This compound serves as a valuable tool in cancer research, particularly in studies focused on signaling pathways involved in leukemia progression and treatment. -
PKM2 Inhibitor
MTP is a potent inhibitor of pyruvate kinase M2 (PKM2) that induces apoptosis in cancer cells through the modulation of caspase-3 activation. Additionally, MTP promotes autophagy and enhances reactive oxygen species (ROS) generation, while also inhibiting JAK2 signaling pathways. This compound is particularly valuable for research applications focused on oral squamous cell carcinoma and related cancer studies. -
TrxR Inhibitor
PAO-Nap is a selective thioredoxin reductase (TrxR) inhibitor modified with a naphthalimide fluorophore linked via aminocaproic acid. This compound induces oxidative stress-mediated apoptosis in HL-60 cells, making it a valuable tool for studying apoptotic pathways and oxidative stress mechanisms in cancer research. Its unique fluorescent properties also facilitate real-time monitoring of cellular responses to TrxR inhibition. -
PDE6/NAMPT Inhibitor
PDEδ/NAMPT IN-1 is a potent dual inhibitor targeting phosphodiesterase 6 (PDE6) with a binding affinity of 0.410 nM and nicotinamide phosphoribosyl transferase (NAMPT) with an IC50 of 2.21 nM. This compound effectively disrupts KRAS-related signaling pathways and hampers the synthesis of nicotinamide adenine dinucleotide (NAD+), leading to apoptosis in KRAS mutant pancreatic cancer cells. PDEδ/NAMPT IN-1 holds significant potential for advancing research in KRAS mutant pancreatic cancer. -
Monoamine Oxidase Inhibitor
Harmol hydrochloride is a potent monoamine oxidase inhibitor that functions as a transcription factor EB (TFEB) activator. It demonstrates significant biological activities, including the induction of cell mitosis, autophagy, and apoptosis. Additionally, Harmol hydrochloride promotes the degradation of α-synuclein by modulating the autophagy-lysosomal pathway, making it relevant in studies of neurodegenerative diseases. Its diverse pharmacological effects also extend to anti-tumor, anti-depressant, and anti-aging activities, and it has shown promise in alleviating motor impairments in models of Parkinson's disease. -
Cathepsin B/CANP Inhibitor
NCO-700 is a potent dual inhibitor of cathepsin B and calcium-activated neutral protease (CANP), exhibiting IC50 values of 0.8 μM and 46 μM, respectively. This compound effectively reduces myocardial fibrin degradation by inhibiting protease activity and demonstrates significant anti-tumor effects on hormone-independent cancer cells, including prostate cancer, by inducing apoptosis. NCO-700 serves as a valuable tool for investigating mechanisms underlying myocardial ischemia and exploring novel treatments for refractory hormone-independent tumors. -
IDO1/TrxR Inhibitor
ZC0101 is a potent dual inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase (TrxR), exhibiting IC50 values of 0.084 μM and 7.98 μM, respectively. This compound demonstrates significant biological activity by inducing apoptosis and promoting reactive oxygen species (ROS) accumulation in cancer cells. ZC0101 is a valuable tool for research applications aimed at understanding cancer cell metabolism and exploring therapeutic strategies targeting IDO1 and TrxR pathways. -
Hsp-Cdc Inhibitor
Hsp90-Cdc37-IN-2 is a selective inhibitor of the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). This compound exhibits potent anti-proliferative activity against cancer cell lines A549, MCF-7, HOS, and HepG2, with IC50 values ranging from 0.41 to 0.94 μM. Hsp90-Cdc37-IN-2 effectively disrupts mitochondrial membrane potential, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase in A549 cells, making it a valuable tool for cancer research and therapeutic investigations.
