Catalog No.
Product Name
Application
Product Information
Citations
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Endogenous Metabolite
L-hydroxylysine dihydrochloride is an endogenous metabolite specific to collagen proteins, generated through the posttranslational hydroxylation of select lysine residues. This amino acid plays a crucial role in stabilizing the collagen triple helix and enhancing its structural integrity. L-hydroxylysine dihydrochloride is widely utilized in research applications focused on collagen synthesis, extracellular matrix studies, and understanding connective tissue disorders. -
Endogenous Metabolites
Glycerol-3-phosphate dehydrogenase from Saccharomyces cerevisiae is an enzyme that catalyzes the oxidation of glycerol-3-phosphate (G3P) to dihydroxyacetone phosphate (DHAP), playing a crucial role in glycerol metabolism and energy production. This rate-limiting enzyme is essential for glycerol production in Saccharomyces cerevisiae, facilitating its adaptation to high osmotic conditions through the regulation of glycerol levels. Glycerol-3-phosphate dehydrogenase is valuable for research in metabolic engineering and related studies of cellular adaptation and energy homeostasis. -
Endogenous Metabolite
2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is an endogenous metabolite derived from the endophytic fungus Phoma macrostoma found within the inner tissue of the medicinal plant Glycyrrhiza glabra Linn. This compound exhibits significant biological activity and may provide insights into plant-fungal interactions and the biosynthesis of secondary metabolites. Its research applications include investigations into natural product chemistry and the exploration of potential therapeutic benefits of compounds sourced from medicinal plants. -
Endogenous Metabolite
12α-Hydroxysteroid dehydrogenase from Bacillus sphaericus is an NAD-dependent enzyme that primarily targets bile acids, exhibiting activity on both bound and unbound forms. This enzyme plays a pivotal role in the metabolism of 12α-hydroxy bile acids and can be utilized to quantify their concentration in serum samples. Its application is significant in studies of bile acid metabolism and related pathophysiological conditions. -
Endogenous Metabolite
Radamide is a selective inhibitor of Grp94, targeting this chaperone protein to exhibit anti-migratory effects. It is primarily utilized in research related to Grp94-associated conditions, including glaucoma, cancer metastasis, and multiple myeloma. Additionally, Radamide derivatives have demonstrated enhanced potency and selectivity through optimized structure-activity relationship studies, making them valuable tools for investigating Grp94's role in various biological contexts. -
Endogenous Metabolite
SAR114137 is an endogenous metabolite known for its significant biochemical activity. It displays altered amorphous content characteristics during the physical processing of the crystalline active pharmaceutical ingredient, with a marked reduction in amorphous API content when subjected to various jet grinding techniques. SAR114137 also demonstrates good chemical stability in pharmaceutical formulations, making it a valuable reagent for research focused on drug formulation and stability assessments. -
Endogenous Metabolite
Diadenosine pentaphosphate pentalithium functions as an endogenous vasoactive purine dinucleotide. This compound plays a significant role in cellular signaling and is involved in various biological processes, particularly in vascular regulation and neurotransmission. It is commonly used in research focused on platelet activity, vasodilation mechanisms, and synaptic transmission across different cell types, including thrombocytes and neuronal cells. -
Endogenous Metabolite
AZD4877 hydrochloride is a selective inhibitor of the microtubule motor protein kinesin-5 (KSP), primarily utilized for its anti-tumor properties. By inhibiting dynein's function, AZD4877 disrupts mitotic spindle assembly, activating the spindle assembly checkpoint and resulting in cell cycle arrest during mitosis. This disruption may lead to apoptosis in rapidly dividing cancer cells, while potentially reducing the risk of peripheral neuropathy commonly associated with other microtubule-targeted therapies. AZD4877 plays a critical role in ensuring the formation of bipolar spindles and the accurate segregation of sister chromatids during cell division. -
Endogenous Metabolite
Decarestrictin A1 is an endogenous metabolite derived from the fungus Penicillium. This compound exhibits notable biological activity, making it valuable in research focused on fungal metabolism and secondary metabolite production. Decarestrictin A1 is useful for investigating the role of fungal metabolites in biochemical pathways and their potential applications in biotechnology and pharmacology. -
Endogenous Metabolite
Glycerophosphoinositol (lysine) is an endogenous phospholipid metabolite that exhibits anti-inflammatory and anti-aging properties. It effectively inhibits UVB-induced prostaglandin E (PGE) secretion in human epidermal keratinocytes (NHEK), making it a valuable compound for research in dermatological applications. Its function in modulating inflammatory responses underscores its potential utility in studies related to skin health and disease. -
Endogenous Metabolite
H-0104 dihydrochloride is a selective inhibitor of Rho-associated protein kinase (ROCK), targeting pathways involved in ocular pressure regulation. This compound has been shown to effectively lower intraocular pressure (IOP) in preclinical models, specifically in monkey eyes. It warrants further investigation to elucidate the mechanisms underlying its IOP-lowering effects, which may not solely rely on ROCK inhibition. H-0104 dihydrochloride is valuable for research applications focused on glaucoma and other conditions associated with elevated IOP. -
Endogenous Metabolite
20-Hydroxy-leukotriene B4 is an endogenous metabolite that plays a role in various biological processes, particularly in immune responses and inflammation. This compound is primarily studied in the context of Sjögren-Larsson Syndrome, aiding in the understanding of its pathophysiology. Researchers utilize 20-Hydroxy-leukotriene B4 to explore its biological activity and potential therapeutic implications related to inflammatory conditions. -
Fungal Metabolite
F-14329 is a tetramic acid fungal metabolite that exhibits significant activity against various fungal strains. This compound serves as a valuable tool for researchers studying fungal biology and developing antifungal therapies. Its unique structure and mechanism of action make it an important candidate for investigations into fungal metabolism and resistance mechanisms. -
Endogenous Metabolite
NP603 is a potent inhibitor of Fibroblast Growth Factor Receptor 1 (FGFR1). It demonstrates significant anti-proliferative activity against endothelial cells, particularly in Human Umbilical Vein Endothelial Cells (HUVEC) stimulated by recombinant human FGF-2, with a minimum effective dose of 0.4 µM. This compound is valuable for research applications focused on angiogenesis and related signaling pathways. -
Endogenous Metabolite
Benanserin hydrochloride is a serotonin receptor antagonist that modulates psychopharmacological activity. It is utilized in research to investigate specific behavioral responses and to assess drug effects, particularly through the measurement of muscle movement and reaction time. This compound is effective for monitoring physiological changes in muscle function and provides reliable bioassay parameters for experimental applications in pharmacology and neuroscience. -
Endogenous Metabolite
ABT-418 is a selective ligand for neuronal nicotinic acetylcholine receptors, primarily targeting cognitive enhancement. It has been shown to improve spatial memory and reduce spatial discrimination deficits, particularly following ventricular damage. ABT-418 holds potential for research applications in attention deficit disorder and related cognitive impairments. -
Endogenous Metabolite
MNI-caged kainate is a photoprotective derivative of the endogenous neuroactive amino acid kainate, with a primary mechanism of action involving the activation of AMPA receptors. Upon photorelease, it elicits substantial inward currents in Purkinje cells, facilitating the investigation of fast synaptic transmission dynamics. MNI-caged kainate is employed in studies aimed at elucidating synaptic receptor mechanisms, significantly contributing to our understanding of excitatory neurotransmission. Its rapid photorelease kinetics, occurring in the sub-microsecond range, makes it an invaluable tool for real-time studies of synaptic activity. -
Fungal Metabolite
Cycloechinulin is a diketopiperazine fungal metabolite that exhibits antifungal properties. Its mechanism involves inhibition of fungal growth, making it valuable in the study of fungal biology and pathogenic mechanisms. Cycloechinulin is commonly used in research applications aimed at exploring novel antifungal therapies and understanding the biochemical pathways involved in fungal metabolism. -
Endogenous Metabolite
1-Oleoyl-2-linoleoyl-rac-glycerol is an endogenous metabolite classified as a diacylglycerol, featuring linoleic and oleic acid moieties. This compound plays a significant role in lipid metabolism and is involved in various signaling pathways within biological systems. It is commonly studied in research applications related to nutrition, food science, and the pharmacological effects of dietary lipids. -
Endogenous Metabolite
Thalicpureine is an endogenous metabolite known for its role as a secondary metabolite in various biological systems. This compound exhibits noteworthy biological activity, particularly in modulating metabolic pathways. Research applications include studies on plant physiology, natural product biosynthesis, and potential therapeutic effects associated with metabolic regulation. -
Endogenous Metabolite
MRS2802 is a selective agonist for the P2Y14 receptor, exhibiting an EC50 value of 63 nM. This compound effectively activates the receptor and may influence platelet function regulation. Its selectivity and activity make MRS2802 a valuable tool for investigating the biological roles and pharmacological characteristics of P2Y receptors. Additionally, MRS2802 may serve as a lead compound in the development of novel antiplatelet therapeutics. -
Endogenous Metabolite
1,3-Diphenethylurea is an endogenous metabolite known for its anti-cancer properties. This compound demonstrates the capability to inhibit tumor growth, making it valuable for cancer research. Its mechanism of action provides insights into novel therapeutic strategies aimed at combating various types of cancer. -
Endogenous Metabolite
PAT-494 is an autotaxin (ATX) inhibitor that demonstrates significant anti-lyso-phosphatidic acid (LPA) activity in biochemical and plasma assays. This compound effectively reduces LPA levels in rat plasma upon oral administration, making it a valuable tool for studying LPA-related biological processes. Structural and activity studies have revealed a novel binding mode of PAT-494, allowing it to effectively occupy the hydrophobic pockets and channels of ATX, thereby providing insights into ATX modulation in various pathological conditions. -
Endogenous Metabolite
Lysinoalanine, an endogenous metabolite, is an amino acid derived from the alkali treatment of native and dinitrophenylated forms of ribonuclease. This compound plays a significant role in various biochemical processes and serves as an important research tool in studies of protein modification and metabolism. Its unique characteristics make it valuable for investigating modifications in protein structure and function. -
Endogenous Metabolite
AKR1C2/3-IN-2 is a selective inhibitor targeting the aldo-keto reductase 1C3 (AKR1C3). This compound effectively inhibits AKR1C3-mediated production of testosterone and induction of prostate-specific antigen (PSA), thereby interfering with the endocrine functions of prostate cancer cells. Its selectivity for AKR1C3 over other aldo-keto reductases suggests its potential utility in addressing drug-resistant prostate cancer. Additionally, AKR1C2/3-IN-2 shows no inhibitory activity against cyclooxygenase (COX) isomerases, reinforcing its specificity in prostate cancer research applications. -
Endogenous Metabolite
KB 5666 is a benzoxazine derivative that inhibits lipid peroxidation, demonstrating significant neuroprotective effects. This compound effectively protects CA1 neurons from post-ischemic damage when administered shortly before or after ischemia, exhibiting a dose-dependent response within one hour of treatment. Furthermore, KB 5666 preserves microtubule-associated protein 2 immunoreactivity in CA1 pyramidal cells and maintains [3H]PDBu binding activity post-ischemia. These properties make KB 5666 a valuable reagent for studying ischemic conditions and their cellular consequences in neurological research. -
Endogenous Metabolite
8-Hydroxyguanine hydrochloride is an endogenous metabolite that serves as a key marker for oxidative DNA damage. Formed through the attack of hydroxyl radicals on guanine, this compound is associated with mutagenesis, particularly leading to a G to T transversion. It is widely utilized in research applications focused on DNA repair mechanisms and the study of oxidative stress in cellular environments. -
Endogenous Metabolite
LY 135114 free base is an endogenous metabolite associated with antitumor activity. As a metabolite of LY 195448, a phenylethanolamine compound, LY 135114 demonstrates potential efficacy in cancer research. Its biological activity may be valuable in studies focused on cancer inhibition and therapeutic applications. -
Endogenous Metabolite
Echiumine is a dehydropyrrolizidine alkaloid derived from the plant Echium plantagineum, functioning primarily as an endogenous metabolite. This compound exhibits notable hepatotoxicity, making it of interest in studies related to liver function and toxicology. Its stability and persistence from honey to mead underscore its relevance in researching dietary and environmental exposures to toxic metabolites. -
Endogenous Metabolite
ATP ditromethamine is an endogenous metabolite primarily involved in energy storage and metabolism. This compound provides the metabolic energy essential for driving metabolic pumps and acts as a crucial coenzyme in cellular processes. Additionally, ATP ditromethamine functions as an important signaling molecule in immune responses and inflammatory pathways, making it valuable for research in cellular metabolism and immunology. -
Endogenous Metabolite
Secaubryenol is a naturally occurring metabolite classified as a 3,4-secocycloartane triterpene, derived from Coussarea macrophylla. It has demonstrated the absence of cytotoxic effects at concentrations up to 10 μg/mL, suggesting its potential as a safe compound for biological applications. Secaubryenol can be utilized in research exploring plant-derived metabolites and their effects on biological systems. -
Endogenous Metabolite
N-Trifluoroacetyladriamycin (AD-41) is a chemotherapeutic agent that primarily targets tumor cells through its antitumor activity. This compound is notable for its significant accumulation in various tissues, including the small intestine, liver, kidneys, spleen, large intestine, lung, and heart, which correlates with its biological efficacy. As a metabolite of Valrubicin, it plays a crucial role in the inhibition of bladder cancer and is relevant in studies investigating metabolic pathways and antitumor mechanisms associated with its derivatives. -
Endogenous Metabolite
D-Ribose 5-phosphate is an endogenous metabolite and a key intermediate in the oxidative branch of the pentose phosphate pathway (PPP). It plays a crucial role in nucleotide and nucleic acid synthesis, making it essential for cellular processes involving DNA and RNA. This compound is valuable for research focused on metabolic pathways, cellular metabolism, and the biochemistry of nucleotides. -
Fungal Metabolite
Maximiscin is a fungal metabolite known for its ability to induce DNA damage. It exhibits selective cytotoxic activity specifically against a subtype of triple-negative breast cancer, making it a valuable compound for cancer research. Its unique mechanism of action and targeted effects provide insights into potential therapeutic applications for challenging malignancies. -
Fungal Secondary Metabolite
Herbaridine B is a fungal secondary metabolite derived from the endophytic fungus Anteaglonium FL0768, which was isolated from the photosynthetic tissues of Selaginella arenicola. This compound exhibits notable biological activity, making it a valuable tool for research in mycology and phytopathology. Its potential applications include studying fungal metabolomics and interactions between endophytes and their host plants. -
Endogenous Metabolite
Protein-arginine deiminase is an enzyme that catalyzes the conversion of peptidyl-arginine to peptidyl-citrulline through hydrolysis. This post-translational modification plays a significant role in various biological processes, including gene regulation, cellular signaling, and the modulation of immune responses. It is particularly relevant in the study of inflammatory diseases and autoimmune conditions, making it a valuable reagent for research applications in biochemistry and molecular biology. -
Endogenous Metabolite
Eprozinol hydrochloride is an endogenous metabolite with antibronchoconstrictor activity. This compound is primarily utilized in the study of bronchospasm and related respiratory disorders. Its mechanism of action makes it a valuable tool for researchers investigating bronchial hyperreactivity and potential therapeutic approaches for asthma and other obstructive pulmonary conditions. -
Endogenous Metabolite
Heptanoyl-L-carnitine chloride is an acylcarnitine that acts as an endogenous metabolite. This compound is known to induce exercise-related changes in the human metabolome, particularly in plasma and skeletal muscle tissues. Its biological activity makes it a valuable reagent for research into metabolic processes and the effects of physical activity on metabolism. -
Endogenous Metabolite
1,3-Distearoyl-2-palmitoyl glycerol is an endogenous metabolite primarily involved in the composition of triglycerides. This compound has been extensively analyzed using various chromatographic techniques, contributing to the characterization of bovine milk fat and identifying a total of 120 distinct triglycerides. Its study offers valuable insights into lipid metabolism and dairy science research applications. -
α-Glucosidase Inhibitor
(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate functions as a selective α-glucosidase inhibitor, exhibiting an IC50 of 10.53 μg/mL. This compound demonstrates significant anti-hepatic fibrosis and anti-diabetic activities, while also inhibiting the proliferation of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. Isolated from the ester derivatives of Impatiens balsamina L. flowers, it serves as a valuable reagent for research focusing on hepatic fibrosis and type 2 diabetes. -
Endogenous Metabolite
Deutarserine is a deuterium-modified analogue of the endogenous metabolite D-serine. It acts as a co-agonist at the NMDA receptor, playing a crucial role in neurotransmission and neuromodulation. This compound is primarily utilized in research focused on schizophrenia and other neuropsychiatric disorders, aiming to elucidate the pathways and therapeutic potential associated with D-serine in adult populations. -
Endogenous Metabolite
Oxogestone phenpropionate is an endogenous metabolite with a primary mechanism of action as a progesterone receptor modulator. This compound is utilized in research to investigate hormone regulation and the physiological effects of progesterone in various biological systems. Its applications extend to studies related to reproductive biology and endocrine function. -
Endogenous metabolites
13,14-dihydro-15(R)-Prostaglandin E1 serves as an analog of 13,14-dihydro-Prostaglandin E1, featuring a hydroxyl group at C-15 in the R configuration. This compound is primarily engaged in research applications focused on endogenous metabolites. Its unique structural characteristics allow for investigations into prostaglandin signaling pathways and their physiological implications. -
Endogenous Metabolite
Guanoxyfen nitrate is a targeted inhibitor of the serine protease TMPRSS2, which is essential for the entry of coronaviruses into host cells. This compound exhibits significant biological activity by inhibiting TMPRSS2-mediated proteolytic processes, thereby diminishing viral infectivity. Additionally, guanoxyfen nitrate effectively suppresses vasoconstrictor responses to sympathetic nerve stimulation, making it a valuable reagent for research in virology and cardiovascular physiology. -
Fungal Metabolite
Beauverolide Ka is a cyclodepsipeptide metabolite derived from the Beauveria bassiana fungus. This compound enhances glucose uptake in cultured rat L6 myoblasts at a concentration of 50 μM and demonstrates protective effects on HEI-OC1 cells at 10 μM. Additionally, Beauverolide Ka exhibits dose-dependent biological activity in both L6 myoblasts and myotubes, making it a valuable reagent for research in cellular metabolism and neuroprotection. -
Endogenous Metabolites
NAD Synthetase is an enzyme that catalyzes the final step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). This enzyme demonstrates differing Km values for its substrates, with values of 200 μM for NAD, 11 μM for ATP, and 0.65 μM for ammonia in Escherichia coli, and 170 μM for NAD, 190 μM for ATP, and 64 μM for ammonia in yeast. NAD Synthetase is applicable for enzymatic assays targeting ATP, ammonia, urea, or creatinine, and is suitable for enzymatic cycling methods. Furthermore, it holds promise for advancing research in metabolic diseases, cancer, aging, and neurodegenerative disorders. -
Fungal Metabolite
Banksialactone A is a fungal metabolite derived from Aspergillus banksianus. This compound exhibits significant antifungal activity, making it a valuable tool for investigating fungal biology and potential therapeutic applications. Research involving Banksialactone A can contribute to understanding fungal metabolism and the development of antifungal agents. -
Endogenous Metabolite
sn-Glycerol 3-phosphate biscyclohexylammonium salt is a key endogenous metabolite involved in glycolysis and lipid metabolism. It is produced through the NADH-dependent activity of cytosolic sn-Glycerol 3-phosphate dehydrogenase, converting dihydroxyacetone phosphate into sn-Glycerol 3-phosphate. This compound is essential for glyceroneogenesis, contributing significantly to lipid synthesis and energy production, making it valuable for research in metabolic pathways and lipid-related studies. -
Endogenous Metabolite
AZD-3289 is a potent β-secretase 1 (BACE1) inhibitor, aimed at modulating the production of β-amyloid protein. Its primary biological activity involves reducing β-amyloid accumulation in the brain, which may contribute to slowing the progression of Alzheimer's disease. AZD-3289 is primarily utilized in research focused on neurodegenerative disorders, with potential applications in enhancing cognitive function by targeting the underlying mechanisms of Alzheimer's pathology. -
Endogenous Metabolite
Flucythrinate is a synthetic pyrethroid that exerts its effects primarily through binding to the vitamin D nuclear receptor (VDR), exhibiting a binding affinity score of -11.0 kcal/mol. This compound possesses endocrine suppressive properties and has been suggested as a multi-target ligand capable of interacting with various proteins implicated in breast cancer. Flucythrinate's efficacy in binding site prediction and affinity estimation has been validated through rigorous screening methods, making it a valuable reagent for research in cancer biology and endocrine disruption studies.
