Catalog No.
Product Name
Application
Product Information
Citations
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Glycosidase Inhibitor
Panosialin wA is a potent glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. Its ability to modulate these enzymes may have applications in research related to carbohydrate metabolism and pathogen interaction. While Panosialin wA does not inhibit the influenza virus, it exhibits a weak anti-microbial effect, making it a useful tool in studies of microbial activity. -
α-Glucosidase Inhibitor
N-Methyltetrachlorophthalimide is a potent inhibitor of α-glucosidase, exhibiting an IC50 of 22.1 μM. This compound is valuable for research focused on anti-diabetic mechanisms as well as antiviral applications, enabling the exploration of therapeutic strategies against conditions related to glycemic control and viral infections. -
Active Compound
Afegostat TFA is a pharmacological chaperone that selectively and reversibly binds to acid-β-glucosidase (GCase) within the endoplasmic reticulum. This interaction enhances the stability and activity of GCase, addressing enzyme deficiencies associated with Gaucher disease. Afegostat TFA is utilized in research exploring enzyme therapy and cellular mechanisms of lysosomal storage disorders. -
Natural product
Sumaresinolic acid is a natural product extracted from the root of Heterophyllum species. Its primary mechanism involves the inhibition of alpha-glucosidase, an enzyme implicated in carbohydrate metabolism. This compound exhibits significant biological activity in regulating blood glucose levels, making it valuable for research in diabetes and metabolic disorders. Its potential applications extend to studies on glycemic control and the development of therapeutic agents targeting carbohydrate metabolism. -
α-Glucosidase inhibitor
α-Glucosidase-IN-45 is an inhibitor targeting α-glucosidase, a key enzyme involved in carbohydrate metabolism. This novel indol-fused pyrano[2,3-D]pyrimidine compound exhibits significant biological activity by obstructing the enzyme's function, thereby influencing glucose absorption and metabolism. It is suitable for research applications related to diabetes, metabolic disorders, and carbohydrate enzyme modulation. -
α-glucosidase Inhibitor
1'-O-Methyl neochebulinate is a hydrolyzable tannin that functions as an α-glucosidase inhibitor, exhibiting an IC50 value of 59.5 μM. Isolated from the fruits of Terminalia chebula Retz, this compound significantly impedes the activity of α-glucosidase, making it relevant for studies in diabetes management and carbohydrate metabolism. Its inhibitory properties provide a useful tool for investigating potential therapeutic strategies for controlling postprandial glucose levels. -
Stable Isotope
Acarbose-d4 is a deuterium-labeled derivative of Acarbose, targeting alpha-glucosidases. This stable isotope maintains the biological activity of its parent compound, functioning as an antihyperglycemic agent with an IC50 of 11 nM. Acarbose-d4 is utilized in research to study glucose metabolism and the enhancement of hypoglycemic effects in combination therapies involving sulfonylureas or insulin. -
Glucosidase Inhibitor
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor with significant potential in glycosidase research. This compound is utilized for its ability to selectively inhibit glucosidase enzymes, making it valuable in studies exploring carbohydrate metabolism and related pathways. Additionally, it serves as a precursor for the preparation of affinity matrices, facilitating the binding of target proteins to resins for purification and analysis. -
α-Glucosidase Inhibitor
Sativanone is a potent α-glucosidase inhibitor, exhibiting an EC50 value of 0.357 mg/mL for rat α-glucosidase. Isolated from Dalbergia tonkinensis, this compound demonstrates antibacterial activity against Ralstonia solanacearum. Additionally, Sativanone exhibits anti-senescent and antioxidant properties, making it a valuable reagent for research in metabolic disorders, bacterial infections, and oxidative stress-related studies. -
Glycosidase Inhibitor
Panosialin D is a glycosidase inhibitor that selectively targets α,β-glucosidase and mannose glycosidase. This compound does not exhibit activity against the influenza virus; however, it demonstrates weak antimicrobial properties. It serves as a valuable reagent for research focused on glycosidase-related pathways and antimicrobial studies. -
α-glucosidase Inhibitor
Enhydrin is a naturally occurring α-glucosidase inhibitor derived from the leaves of Smallanthus sonchifolius. It demonstrates potent inhibitory activity with an IC50 value of 34.17 μg/mL, making it relevant for the management of postprandial hyperglycemia. Research indicates that Enhydrin can effectively reduce blood glucose levels in diabetic rat models, supporting its potential application in diabetes research and therapy development. -
α-Glucosidase Inhibitor
Cembrene A is an α-glucosidase inhibitor derived from the soft coral S. crassa, demonstrating an IC50 value of 30.31 μM. This compound exhibits minimal cytotoxicity in human normal hepatocyte (LO2) cells, with an IC50 greater than 100 μM. Cembrene A is a valuable reagent for research focused on diabetes and the modulation of carbohydrate metabolism. -
Alpha-Glucosidase Inhibitor
Acarbose sulfate is a potent alpha-glucosidase inhibitor, exhibiting an IC50 of 11 nM. This antihyperglycemic agent is utilized in research to investigate its potential to enhance the hypoglycemic effects of sulfonylureas or insulin. Its mechanism of action involves the modulation of carbohydrate absorption, making it valuable in studies related to diabetes and blood glucose regulation. -
α-Glucosidase Inhibitor
Arisanschinin D is an inhibitor of α-Glucosidase, a critical enzyme involved in carbohydrate metabolism. This compound can be isolated from Schisandra arisanensis and is of particular interest for research in diabetes management and metabolic disorders. Its ability to modulate enzyme activity makes it a valuable tool for studying the effects of carbohydrate absorption and glucose homeostasis. -
Glycosidase Inhibitor
Cefetrizole is an α-Glucosidase inhibitor that exhibits potent enzymatic activity, with an IC50 of 2.1 μM and a Ki value of 0.578 μM. This compound is primarily utilized in research applications focused on carbohydrate metabolism and associated disorders. Its ability to inhibit glycosidase activity makes it a valuable tool for investigating enzymatic pathways and developing therapeutic strategies. -
Iron-containing Protein
Hemoglobin is an iron-containing protein found in red blood cells that primarily functions in oxygen transport and binding. It plays a crucial role in gas exchange by transporting carbon dioxide, nitric oxide, hydrogen sulfide, and sulfide. Additionally, hemoglobin acts as an inducer of heme oxygenase-1 (HO-1), contributing to antioxidant defense in tissues by absorbing excess oxygen. Its biological activity makes it a valuable reagent for studies in oxygen metabolism, respiratory physiology, and redox signaling. -
Heme Oxygenase Inhibitor
Zn(II) Mesoporphyrin IX is a potent inhibitor of heme oxygenase, particularly affecting the enzymatic activity in bone marrow. This compound demonstrates significant biological activity by inhibiting the growth of erythroid and myeloid progenitor cells, as well as blocking rhG-CSF-induced mobilization of these cells into peripheral blood. Zn(II) Mesoporphyrin IX is suitable for research applications involving hematopoietic regulation. However, its photochemical properties and potential toxicity to hematopoietic growth warrant careful consideration in experimental designs. -
Negative Control for Zn (II) Protoporphyrin
Cu(II) Protoporphyrin IX serves as a negative control for Zn(II) Protoporphyrin, which acts as an inhibitor of heme oxygenase. Heme oxygenase plays a significant role in various biological processes, including tumor cell resistance to chemotherapy, modulation of free radical formation, and management of inflammation. This reagent is valuable for studies investigating the pathways linked to vascular repair and the mechanistic understanding of heme oxygenase-related processes. -
Heme Oxygenase (HO) Inducer
Mn(III) Protoporphyrin IX Chloride is a potent inducer of heme oxygenase (HO) that enhances the expression of δ-aminolevulinate synthase and HO genes in chick embryo liver cells at a concentration of 10 μM. This metalloporphyrin is relevant for studying heme biosynthesis and degradation pathways. Additionally, Mn(III) protoporphyrin IX chloride has been utilized in the development of nanobialys for magnetic resonance imaging (MRI) of fibrin clots in vitro, as well as in the synthesis of metalloporphyrin conjugates with microperoxidase activity, further expanding its applications in chemical research. -
HO-1 Inducer
Probucol dithiobisphenol (DTBP) is a potent inducer of heme oxygenase 1 (HO-1) with notable antioxidant properties. It effectively inhibits atherosclerotic lesions in the aorta of Apoe−/− mice and promotes re-endothelialization, thereby reducing restenosis in rabbit arterial injury models. This compound is orally active, making it a valuable reagent for investigating vascular health and potential therapeutic applications in cardiovascular diseases. -
HO-1 Inhibitor
Heme Oxygenase-1-IN-3 is a selective inhibitor of heme oxygenase-1 (HO-1), characterized by a dissociation constant (Kd) of 141 nM. This compound is valuable for investigating the role of HO-1 in cancer progression and neurodegenerative diseases. Its specificity makes it an essential tool for researchers studying the mechanism of HO-1 and its implications in various pathological conditions. -
Herbicide
Glufosinate ammonium is a phosphinic acid analogue of glutamic acid, primarily functioning as a herbicide. Upon uptake by plant cells, it is converted into L-phosphinothricin (PT), which disrupts amino acid synthesis, leading to the inhibition of protein synthesis. This compound demonstrates neurotoxic effects, making it significant in studies related to herbicidal activity and plant defense mechanisms. Its applications extend to agricultural research and the investigation of herbicide resistance in crops. -
CYP2C9/CYP3A4 Inhibitor
AR-C141990 functions as a dual inhibitor of CYP2C9 and CYP3A4, exhibiting IC50 values of 16 μM for both enzymes. This compound is recognized for its significant bioactivity, particularly as it inhibits the monocarboxylate transporter MCT1 with a Ki value of 4.8 nM. AR-C141990 is employed in research applications focused on drug metabolism and pharmacokinetics, as well as studies investigating interactions between drugs and metabolic pathways. -
CYP1B1 Activator
17-HETE is a metabolite of arachidonic acid produced via cytochrome P-450 pathways, comprising the 17R-HETE and 17S-HETE enantiomers. It acts as an allosteric activator of cytochrome P450 1B1 and an ATPase inhibitor, thereby playing a significant role in the induction of cardiac hypertrophy. This compound is valuable for research in cardiovascular biology and cytochrome P450 enzyme activity. -
CYP1B1 Activator
17(S)-HETE is a metabolite of arachidonic acid produced via cytochrome P-450 pathways. This compound functions as an allosteric activator of cytochrome P450 1B1 and inhibits ATPase activity, which may contribute to the induction of cardiac hypertrophy. 17(S)-HETE is primarily utilized in research focusing on cardiovascular biology and cytochrome P450 enzyme functions. -
Endogenous Metabolite
Cotinine, a primary metabolite of nicotine, acts as an endogenous biomarker for tobacco exposure. This alkaloid exhibits vasodepressor activity and has demonstrated antiproliferative effects when combined with nicotine against conditions such as pterygium. Additionally, (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, facilitating dopamine release. Due to its diverse biological activities, cotinine is employed in research focused on cardiovascular and inflammatory diseases. -
11β-HSD2 Inhibitor
18β-Glycyrrhetyl-3-O-sulfate is a potent inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), exhibiting an IC50 value of 0.10 µM in rat kidney microsomes. As the principal metabolite of Glycyrrhetinic acid, this compound serves as a substrate for organic anion transporters OAT1 and OAT3. Its anti-inflammatory properties make it a valuable tool for studying pseudohyperaldosteronism and related conditions in biochemical and pharmacological research. -
Endogenous Metabolite
Estradiol 3-sulfate 17-glucuronide potassium is an endogenous metabolite derived from estradiol, specifically targeting the multidrug resistance protein (MRP). It is known to inhibit MRP-mediated transport of 17β-Estradiol 17-(β-D-Glucuronide) with an inhibition constant (Ki) of 22 μM. This compound is useful in studying the pharmacokinetics of estrogenic compounds and understanding their role in hormone metabolism and transport mechanisms. -
CRM1 Degrader
CRM1 Degrader 1 is a targeted agent that selectively degrades chromosome region maintenance 1 (CRM1), a nuclear exporter critical for the transport of various tumor suppressor proteins. By inducing apoptosis in gastric carcinoma cells, CRM1 Degrader 1 demonstrates significant anti-proliferative effects, making it a valuable tool for cancer research. This compound is primarily used to explore therapeutic strategies aimed at regulating CRM1-related pathways in cancer biology. -
Drug Metabolite
α-Hydroxy etizolam is the primary metabolite of Etizolam, exhibiting a similar pharmacological profile and high affinity for benzodiazepine receptors. This compound plays a significant role in understanding the metabolic pathways and effects of Etizolam in biological systems. It is utilized in biochemical research to investigate the pharmacodynamics and pharmacokinetics associated with anxiolytic and sedative activities. -
Endogenous Metabolite
Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine that serves as a modulator of glycine transport. It exhibits inhibitory activity on the GlyT2 receptor, reducing glycine responses by 16.8% at concentrations up to 3 μM. This compound is of interest in research focusing on neurotransmitter regulation and metabolic processes related to acylcarnitines. -
Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC) is an endogenous metabolite primarily involved in cholesterol homeostasis within the brain. As a potent and selective positive allosteric modulator of N-methyl-D-aspartate receptors (NMDARs), 24S-OHC functions through a unique mechanism distinct from other allosteric modulators. Its high levels in both the brain and circulation make it a valuable tool for research into neurological functions and disorders related to cholesterol metabolism and synaptic transmission. -
Acetylcholinesterase Inhibitor, Butyrylcholinesterase Inhibitor, Carbonic Anhydrase I/II Inhibitor, α-Glycosidase Inhibitor
Vescalagin is a hexahydroxyphenol that acts as an inhibitor of acetylcholinesterase and butyrylcholinesterase, as well as carbonic anhydrases I and II, and α-glycosidase. It demonstrates potent inhibitory activity with Ki values of 5.87 nM for AChE, 3.89 nM for BChE, 11.75 nM for hCA I, 16.23 nM for hCA II, and 16.08 nM for α-glycosidase. Vescalagin exhibits non-competitive inhibition for hCA I, hCA II, and α-glycosidase, while also reducing hyperglycemia and hypertriglyceridemia in dietary models. Additionally, it possesses anti-inflammatory and antioxidant activities, making it a valuable compound for research in diabetes and metabolic disorders. -
Endogenous Metabolite
3-Hydroxyisobutyric acid sodium is an endogenous metabolite involved in the metabolic pathways of L-valine and thymine. It serves as a mediator in endothelial cell fatty acid transport and has implications in insulin resistance. Additionally, this compound can inhibit key enzymes involved in energy metabolism in the cerebral cortex of young rats. Elevated levels of 3-Hydroxyisobutyric acid sodium are associated with conditions such as 3-hydroxyisobutyric aciduria, diabetes, and ketoacidosis, making it a significant target for research on metabolic disorders. -
Stable Isotope
Verapamil-d3 hydrochloride is a deuterium-labeled derivative of the calcium channel blocker, verapamil hydrochloride. It serves as a potent inhibitor of P-glycoprotein (P-gp) and CYP3A4, facilitating detailed pharmacological studies. This stable isotope is primarily utilized in research related to hypertension, cardiac arrhythmias, and angina, providing insight into drug metabolism and transport mechanisms in various biological systems. -
IDO1 Inhibitor
IDO1-IN-19 is a selective inhibitor of Indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 value of 8.64 μM for CYP2C9. In addition, it modulates cardiac ion channels with IC50 values of 12 μM for IKr, 40 μM for INa, and 8.3 μM for ICa. This compound is valuable for investigating the mechanisms of cancer biology and has potential applications in cancer therapeutics. -
IDHP Isomer
(R)-IDHP is an isomer of isovaleryl-DL-3-hydroxybutyric acid, functioning primarily by inhibiting Ca2+ release and modulating Ca2+ inward flow in both voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. This compound exhibits vasorelaxant properties and is valuable in research focused on cardiovascular disease mechanisms and treatments. Its biological activity makes it a useful tool for investigating vascular dynamics and related pathophysiological conditions. -
Oxidative/Nitrosative Stress Biomarker
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal recognized as a biomarker for oxidative and nitrosative stress. It acts as both a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) and can modulate various signaling pathways by forming covalent adducts with nucleophilic sites on proteins, nucleic acids, and membrane lipids. This compound is implicated in cancer biology, particularly through its influence on mitochondrial function, making it a valuable tool for research in cellular stress responses and oncogenesis. -
ALDH Inhibitor
4-Diethylaminobenzaldehyde is a reversible inhibitor of aldehyde dehydrogenases (ALDHs), exhibiting a Ki value of 4 nM specifically for ALDH1. This compound has demonstrated significant anti-androgenic activity with an IC50 of 1.71 μM. Its inhibitory effects on ALDH activities make it a valuable tool in biological research, particularly in studies focused on metabolic processes and hormonal regulation. -
ALDH1 Inhibitor
ABD-3001 is a selective inhibitor of aldehyde dehydrogenase 1 (ALDH1). It has demonstrated potential in the study of refractory or relapsed acute myeloid leukemia and high-risk myelodysplastic syndrome. This compound may serve as a valuable tool for elucidating the role of ALDH1 in hematological malignancies and developing targeted therapies. -
Acohol use disorder
Lefelsiran sodium is a small interfering RNA (siRNA) that targets aldehyde dehydrogenase 2 (ALDH2). It is utilized in research to investigate the mechanisms underlying alcohol use disorder. By downregulating ALDH2, Lefelsiran sodium may provide insights into metabolic pathways associated with alcohol consumption and the potential therapeutic approaches for treating alcohol-related conditions. -
ALDH1a2 Inhibitor
Win 18446 is a selective inhibitor of the testes-specific enzyme ALDH1a2, exhibiting an IC50 of 0.3 μM. This compound effectively reverses spermatogenesis across various species and disrupts the biosynthesis of retinoic acid from retinol within the testes. It is valuable for research applications focused on reproductive biology and the modulation of retinoid signaling pathways. -
ALDH18A1 Inhibitor
YG1702 is a selective inhibitor of ALDH18A1, a key enzyme involved in the biosynthesis of polyamines. This compound has demonstrated significant inhibitory effects on the proliferation of MYCN-amplified neuroblastoma cells and leads to down-regulation of MYCN expression. YG1702 binds to ALDH18A1 with high affinity, suggesting it may alter the enzyme’s activity and function. This reagent is valuable for research applications focused on neuroblastoma and cellular growth regulation. -
ALDH-2 Inhibitor
CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), demonstrating an IC50 of 29 nM. This compound also exhibits inhibitory effects on ALDH-1 with an IC50 of 1.3 μM. CVT-10216 has been shown to reduce excessive alcohol consumption in alcohol-preferring rat models and exhibits anxiolytic properties, making it valuable for research into alcohol use disorders and anxiety-related conditions. -
ALDH3A1 Inhibitor
ALDH3A1-IN-3 is a selective inhibitor of the enzyme ALDH3A1, exhibiting a Ki value of 4.7 μM and an IC50 value of 16 μM. This compound shows no inhibitory activity against ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2 in vitro. ALDH3A1-IN-3 is suitable for investigations in cellular oxidation processes and cancer research, making it a valuable tool for studying the role of ALDH3A1 in various biological contexts. -
ALDH3A1 Inhibitor
ALDH3A1-IN-1 is a potent inhibitor of the aldehyde dehydrogenase 3A1 (ALDH3A1) enzyme, exhibiting an IC50 of 1.61 μM. This compound demonstrates superior efficacy compared to DEAB in targeting patient-derived primary prostate tumor epithelial cells, both as a standalone treatment and in combination with docetaxel. ALDH3A1-IN-1 is a valuable tool for investigating ALDH3A1's role in cancer biology and therapeutic resistance. -
ALDH1B1 Inhibitor
IGUANA-1 is a selective inhibitor of ALDH1B1, exhibiting potent activity against this target. It demonstrates minimal mitochondrial toxicity, making it suitable for various experimental applications. Its antitumor properties position IGUANA-1 as a valuable compound for cancer research and drug development. -
ALDH1A3 Inhibitor
ALDH1A3-IN-3 is a potent inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3), exhibiting an IC50 of 0.26 μM. This compound shows potential as a research tool for studying prostate cancer and can aid in understanding the role of ALDH1A3 in tumor biology. However, it functions as a substrate for ALDH3A1, which may limit its specificity as a selective inhibitor. -
ALDH1A3 Inhibitor
ALDH1A3-IN-1 is a potent inhibitor of aldehyde dehydrogenase 1A3 (ALDH1A3), exhibiting an IC50 value of 0.63 μM and a Ki of 0.46 μM. This compound plays a significant role in cancer research, particularly in the study of prostate cancer, by modulating metabolic pathways associated with tumor progression. Researchers can utilize ALDH1A3-IN-1 to explore the implications of ALDH1A3 inhibition in cellular and molecular contexts pertaining to oncology. -
ALDH1A1 Inhibitor
CM037 is a highly selective and competitive inhibitor of the enzyme ALDH1A1, with an IC50 of 4.6 μM. By blocking the catalytic activity of ALDH1A1, CM037 inhibits the activation of the HIF-1α/VEGF signaling pathway. This reagent is primarily utilized to investigate the role of ALDH1A1 in the regulation of cancer stem cells and angiogenesis, particularly in breast cancer models, highlighting its potential to obstruct tumor angiogenesis and stem cell properties.
