Win 18446 is a selective inhibitor of the testes-specific enzyme ALDH1a2, exhibiting an IC50 of 0.3 μM. This compound effectively reverses spermatogenesis across various species and disrupts the biosynthesis of retinoic acid from retinol within the testes. It is valuable for research applications focused on reproductive biology and the modulation of retinoid signaling pathways.
Win 18446 is a selective inhibitor of the testes-specific enzyme ALDH1a2, exhibiting an IC50 of 0.3 μM. This compound effectively reverses spermatogenesis across various species and disrupts the biosynthesis of retinoic acid from retinol within the testes. It is valuable for research applications focused on reproductive biology and the modulation of retinoid signaling pathways.
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