CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), demonstrating an IC50 of 29 nM. This compound also exhibits inhibitory effects on ALDH-1 with an IC50 of 1.3 μM. CVT-10216 has been shown to reduce excessive alcohol consumption in alcohol-preferring rat models and exhibits anxiolytic properties, making it valuable for research into alcohol use disorders and anxiety-related conditions.
CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2), demonstrating an IC50 of 29 nM. This compound also exhibits inhibitory effects on ALDH-1 with an IC50 of 1.3 μM. CVT-10216 has been shown to reduce excessive alcohol consumption in alcohol-preferring rat models and exhibits anxiolytic properties, making it valuable for research into alcohol use disorders and anxiety-related conditions.
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