4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal recognized as a biomarker for oxidative and nitrosative stress. It acts as both a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) and can modulate various signaling pathways by forming covalent adducts with nucleophilic sites on proteins, nucleic acids, and membrane lipids. This compound is implicated in cancer biology, particularly through its influence on mitochondrial function, making it a valuable tool for research in cellular stress responses and oncogenesis.
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal recognized as a biomarker for oxidative and nitrosative stress. It acts as both a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2) and can modulate various signaling pathways by forming covalent adducts with nucleophilic sites on proteins, nucleic acids, and membrane lipids. This compound is implicated in cancer biology, particularly through its influence on mitochondrial function, making it a valuable tool for research in cellular stress responses and oncogenesis.
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