YCH1899 is an orally active PARP inhibitor, demonstrating a potent IC50 of less than 0.001 nM for PARP1/2. This compound exhibits significant antiproliferative effects against Capan-1 cells resistant to Olaparib and Talazoparib, with IC50 values of 0.89 nM and 1.13 nM, respectively. YCH1899 also presents favorable pharmacokinetic properties in rat models, making it a valuable tool for research in cancer therapeutics and resistance mechanisms.
YCH1899 is an orally active PARP inhibitor, demonstrating a potent IC50 of less than 0.001 nM for PARP1/2. This compound exhibits significant antiproliferative effects against Capan-1 cells resistant to Olaparib and Talazoparib, with IC50 values of 0.89 nM and 1.13 nM, respectively. YCH1899 also presents favorable pharmacokinetic properties in rat models, making it a valuable tool for research in cancer therapeutics and resistance mechanisms.
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