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PARP1-IN-39

PARP1 Inhibitor

PARP1-IN-39 is a potent inhibitor of PARP1, exhibiting an IC50 of 0.22 nM, and an IC50 of 1.57 nM in human breast cancer cells. This compound is valuable for investigating cancers associated with DNA repair deficiencies, including those linked to BRCA1/2 mutations, and is applicable in studies of breast, ovarian, pancreatic, and prostate cancers. PARP1-IN-39 facilitates research into targeted therapies that exploit the vulnerabilities of cancer cells with defective DNA repair mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3054988-47-2
Applications	PARP1 Inhibitor
Formula	C₂₄H₁₉F₃N₈O₂
Molecular Weight	508.46
SMILES	CCNC(C1=CC=C(N2C=C3CN(CC3=N2)CC4=C(C5=C(N6N=CC(F)=C6C(N5)=O)C=C4)F)C(F)=N1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.