Fig. 1 · Structure
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PARP-1-IN-23
PARP-1 Inhibitor
PARP-1-IN-23 is a selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP-1), exhibiting an IC50 of 12.38 nM. This compound demonstrates significant antitumor activity in vivo, making it a valuable tool for studying the mechanisms of cancer progression and treatment. Its inhibition of PARP-1 suggests potential applications in enhancing the efficacy of chemotherapy and targeting cancer cell survival pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2976497-48-8 |
| Applications | PARP-1 Inhibitor |
| Formula | C22H18BrN3O5S |
| Molecular Weight | 516.36 |
| SMILES | BrC1=CC(C2=NC3=C(C=CC=C3N2)C(N)=O)=CC(OC)=C1OS(=O)(C4=CC=CC=C4C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.