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PARP1-IN-18

PARP1 Inhibitor

PARP1-IN-18 is a potent inhibitor of the poly(ADP-ribose) polymerase 1 (PARP1) enzyme, demonstrating an IC50 value of 2.7 nM. This compound exhibits significant anticancer activity, making it a valuable tool for research applications targeting DNA repair mechanisms and cancer therapeutics. PARP1-IN-18 can be utilized to explore PARP-mediated cellular processes and evaluate its potential in combination therapies for various malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2958609-64-6
Applications	PARP1 Inhibitor
Formula	C₂₄H₂₃F₄N₅O₂
Molecular Weight	489.47
SMILES	O=C(NC1CC1)C2=CC=C(N3CCN(CC4=CC=C(C=C(C(F)F)C(N5)=O)C5=C4F)CC3)C(F)=N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.