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iRucaparib-TP3

PARP1 Degrader

iRucaparib-TP3 is a selective degrader of PARP1, exhibiting a DC50 of 36 nM. This compound is instrumental in research focused on oncology, particularly in the context of BRCA-mutated cancers, as well as in the investigation of neurodegenerative diseases. Its ability to modulate PARP1 levels positions it as a valuable tool for understanding the mechanisms underlying these diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	2410557-01-4
Applications	PARP1 Degrader
Formula	C₄₆H₅₂FN₉O₈
Molecular Weight	877.96
SMILES	O=C1NCCC2=C(C3=CC=C(CN(C)CCCCC4=CN(CCOCCOCCOCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)N=N4)C=C3)NC8=CC(F)=CC1=C82

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.