Vrucaparib-TP4

Catalog No.: A29005
PARP1 PROTAC-type Degrader
Vrucaparib-TP4 is a PROTAC-type degrader that targets PARP1. It facilitates the ubiquitination and subsequent degradation of PARP1, making it a valuable tool in cancer research. This compound is particularly useful for investigating the role of PARP1 in tumor biology and evaluating therapeutic strategies that exploit the degradation pathway for potential anti-tumor effects.
Grouped product items
Size Stock
5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVrucaparib-TP4 is a PROTAC-type degrader that targets PARP1. It facilitates the ubiquitination and subsequent degradation of PARP1, making it a valuable tool in cancer research. This compound is particularly useful for investigating the role of PARP1 in tumor biology and evaluating therapeutic strategies that exploit the degradation pathway for potential anti-tumor effects.
Product Information
Catalog NumA29005
FormulaC58H75FN10O9S
Molecular Weight1107.34
CAS Number2410557-03-6
SMILESO=C1NCCC2=C(NC3=CC(F)=CC1=C32)C4=CC=C(C=C4)CN(CCCCC5=CN(N=N5)CCOCCOCCOCCOCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)O)=O)C(C)(C)C)=O)C
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