Fig. 1 · Structure
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PARP1-IN-29
PARP-1 Inhibitor
PARP1-IN-29 is a potent PARP-1 inhibitor with an IC50 of 6.3 nM, demonstrating strong efficacy in modulating DNA damage repair pathways. Labeled with [18F], this compound is suitable for positron emission tomography (PET) imaging, allowing for targeted visualization of PARP-1 activity in tumors. Its applications extend to oncology and imaging research, providing valuable insights into cancer biology and treatment response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1567375-93-2 |
| Applications | PARP-1 Inhibitor |
| Formula | C18H16FN3O2 |
| Molecular Weight | 325.34 |
| SMILES | O=C1NCCN2C(C3=CC=C(OCCF)C=C3)=NC4=CC=CC1=C42 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.