Fig. 1 · Structure
Documents & Downloads
PARP7-IN-12
PARP7 Inhibitor
PARP7-IN-12 is a potent inhibitor of PARP7, exhibiting an IC50 value of 7.836 nM. This compound demonstrates significant potential in cancer research by modulating poly(ADP-ribose) polymerase activity, which is associated with DNA damage response pathways. PARP7-IN-12 may serve as an effective tool for elucidating the role of PARP7 in tumor biology and for developing therapeutic strategies targeting PARP-related pathways in cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2819700-92-8 |
| Applications | PARP7 Inhibitor |
| Formula | C23H27ClF3N5O5 |
| Molecular Weight | 545.94 |
| SMILES | CC1=C2C(N3[C@@](CCO2)([H])CN(CC3)C(CCOC[C@H](C)OC4=C(C(NN=C4)=O)C(F)(F)F)=O)=NC=C1Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.