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PARP1-IN-28

PARP Inhibitor

PARP1-IN-28 is a potent inhibitor of Poly(ADP-ribose) polymerase 1 (PARP1), a crucial enzyme involved in DNA repair and cellular response to stress. This compound exhibits significant anti-proliferative activity and is particularly relevant in cancer research, enabling studies on tumor cell viability and resistance mechanisms. Its application extends to assessing the efficacy of combination therapies in oncology, particularly in contexts involving homologous recombination deficiency.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2855059-11-7
Applications	PARP Inhibitor
Formula	C₂₃H₂₆N₆O₂
Molecular Weight	418.49
SMILES	O=C(C1=NC=C(N2CCN(CC2)CC3=CC4=C(C=C(C5CC5)C(N4)=O)N=C3)C=C1)NC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.