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Lerzeparib

PARP Inhibitor

Lerzeparib is a potent inhibitor of poly(ADP-ribose) polymerase (PARP), demonstrating significant antineoplastic activity. By obstructing the PARP enzyme, Lerzeparib effectively disrupts DNA repair mechanisms in cancer cells, leading to increased cellular apoptosis. This compound is primarily utilized in cancer research to explore therapeutic strategies for tumors with homologous recombination deficiencies, such as BRCA-mutated cancers.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2459693-01-5
Applications	PARP Inhibitor
Formula	C₂₁H₂₀FN₃O₂
Molecular Weight	365.40
SMILES	O=C1C2=C3C(CON1)=C(C4=CC=C([C@]5(CCCN5)C)C=C4)NC3=CC(F)=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.