Fig. 1 · Structure
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KCL-440
PARP Inhibitor
KCL-440 is a potent PARP inhibitor that effectively penetrates the central nervous system, exhibiting an IC50 of 68 nM for PARP-1 inhibition. This compound is primarily utilized in research exploring DNA repair mechanisms, cancer therapy, and neurodegenerative disease models, making it a valuable tool for studying therapeutic strategies targeting cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 651029-09-3 |
| Applications | PARP Inhibitor |
| Formula | C18H18N2O2 |
| Molecular Weight | 294.35 |
| SMILES | O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.