Catalog No.
Product Name
Application
Product Information
Citations
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sGC Activator
Avenciguat is a potent and orally active soluble guanylate cyclase (sGC) activator. By enhancing the production of cyclic guanosine monophosphate (cGMP), Avenciguat effectively improves nitric oxide (NO) signaling pathways. This compound is valuable for research on chronic kidney disease (CKD) and diabetic kidney disease (DKD), offering insights into therapeutic mechanisms and potential treatment strategies. -
sGC Activator
(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC). This compound has demonstrated the ability to mitigate renal damage progression in the ZSF1 rat model, suggesting its potential therapeutic application in diabetic nephropathy. The modulation of sGC activity may offer novel insights into the treatment of related renal disorders. -
SGC Agonist
SGC Agonist 2 is a selective agonist of soluble guanylate cyclase (SGC), an essential enzyme in the nitric oxide (NO) signaling pathway that produces cyclic GMP (cGMP). This compound demonstrates significant biological activity in modulating vasodilation and has implications for research into cardiovascular diseases, including heart failure, pulmonary hypertension, angina, and myocardial infarction, as well as fibrotic conditions such as renal fibrosis and systemic sclerosis. Its utility in investigating these pathologies makes SGC Agonist 2 a valuable tool for advancing cardiovascular and fibrosis-related research. -
Guanylate Kinase
Guanylate kinase is a key enzyme in the guanine salvage pathway, facilitating the conversion of guanosine monophosphate (GMP) and deoxyguanosine monophosphate (dGMP) through the transfer of a terminal phosphoryl group from ATP in a reversible, magnesium-dependent reaction. This enzyme plays a crucial role in nucleotide metabolism and is essential for maintaining nucleotide pools in cells. Research applications include studies on energy metabolism, synthetic biology, and the development of antiviral and anticancer therapies targeting nucleotide biosynthesis pathways. -
sGC Activator
sGC activator 1 is a potent activator of soluble guanylate cyclase (sGC), a key enzyme involved in the nitric oxide signaling pathway. By enhancing sGC activity, this compound increases intracellular levels of cyclic guanosine monophosphate (cGMP), leading to various biological effects such as vasodilation and smooth muscle relaxation. sGC activator 1 is utilized in research applications focused on cardiovascular diseases, neuroprotection, and cellular signaling mechanisms. -
NO Donor Agent
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor that releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells. This process increases cGMP levels, resulting in vasodilation. Additionally, RIG 200 significantly inhibits collagen-induced platelet aggregation in platelet-rich plasma (PRP), making it a valuable tool for research focused on thrombus prevention and cardiovascular studies. -
Guanylate Cyclase Activator
Nurandociguatum is a guanylate cyclase activator that enhances intracellular cGMP levels, leading to vasodilation and modulation of nitric oxide signaling. This compound is primarily utilized in cardiovascular research, particularly in studies investigating pulmonary hypertension and heart failure mechanisms. Its ability to stimulate guanylate cyclase makes it a valuable tool for exploring therapeutic strategies targeting vascular relaxation and nitric oxide pathways. -
sGC Agonist
S-3448 is a soluble guanylate cyclase (sGC) agonist that selectively activates both the heme-containing and heme-deficient forms of sGC, independent of nitric oxide and heme. This compound demonstrates significant biological activity in modulating intracellular signaling pathways related to vasodilation and cardiovascular function. S-3448 is valuable for research applications focused on cardiovascular diseases, including arterial hypertension and pulmonary hypertension, providing insights into potential therapeutic strategies. -
SGC Agonist
SGC Agonist 1 is a potent agonist of soluble guanylate cyclase (SGC), enhancing intracellular signaling pathways. It is characterized by improved solubility and high cell permeability, making it suitable for in vitro and in vivo studies. SGC Agonist 1 holds potential for research applications in cardiovascular disease, aiding in the exploration of therapeutic strategies for related conditions. -
sGC Activator
GSK2181236A is a soluble guanylate cyclase (sGC) activator that is resistant to nitric oxide. This compound promotes vasodilation, reduces mean arterial pressure, and mitigates the progression of cardiac hypertrophy. GSK2181236A is applicable in research focused on cardiovascular diseases, including hypertension and related pathologies. -
Guanylate Cyclase Activator
Guanylin (mouse, rat) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. This compound plays a crucial role in regulating electrolyte and fluid balance in the intestine. Guanylin is commonly used in research related to diarrheal diseases and gastrointestinal disorders, providing insights into mechanisms of fluid secretion and absorption. -
NO Donor
SE 175 is an organic nitrate compound that functions as a nitric oxide (NO) donor through the reductive conversion of its nitrate group. Its primary mechanism involves the stimulation of endothelial soluble guanylate cyclase, resulting in pronounced aortic vasorelaxation, with an EC50 value of 0.20 µM. This compound is valuable for research investigating vascular biology and cardiovascular function, particularly in studies related to NO-mediated signaling pathways. -
Soluble Guanylate Cyclase Agonist
IWP-051 is an agonist for soluble guanylate cyclase, with an EC50 of 290 nM. It effectively stimulates the production of cyclic guanosine monophosphate (cGMP) and shows a synergistic effect with nitric oxide (NO). This compound is suitable for research focusing on cardiovascular function, smooth muscle relaxation, and other cGMP-related signaling pathways. Moreover, IWP-051 demonstrates favorable pharmacokinetic properties in rat models, making it a valuable tool for in vivo studies. -
Guanylate Cyclase Inhibitor
2-Chloro-ATP functions as a soluble guanylate cyclase inhibitor, impacting intracellular signaling pathways. This compound elevates intracellular calcium concentrations at low concentrations, utilizing a mechanism that does not rely on inositol phosphate production. It is valuable for studies investigating the role of guanylate cyclase in various physiological and pathological conditions. Researchers can utilize 2-Chloro-ATP to understand the modulation of calcium signaling in cellular processes. -
sGC Activator
A-350619 is a selective activator of soluble guanylate cyclase (sGC), resulting in elevated intracellular levels of cyclic guanosine monophosphate (cGMP). This compound has been demonstrated to significantly induce penile erection, highlighting its potential therapeutic applications in erectile dysfunction research. Further studies may explore its effects on vascular smooth muscle relaxation and other cGMP-related biological processes. -
sGC Activator
A-350619 hydrochloride is a soluble guanylate cyclase (sGC) activator that enhances intracellular cGMP levels. This compound exhibits significant biological activity in the modulation of vasodilation and neurotransmission, making it relevant for research into erectile dysfunction and related vascular disorders. Its role in enhancing sGC activity makes it a valuable tool for investigating therapeutic strategies targeting nitric oxide signaling pathways. -
Histamine H1 Receptor Antagonist
Terfenadine N-oxide is a histamine H1 receptor antagonist with an IC50 value of 2.73 μM, also exhibiting inhibition of the hERG potassium channel with an IC50 of 0.698 μM. This compound is valuable for investigating histamine-related allergic diseases and the role of hERG channels in arrhythmias. Its dual activity makes it a useful tool for research in pharmacology and toxicology related to allergic responses and cardiac rhythm disturbances. -
ICMT Inhibitor
ICMT-IN-1 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.0013 μM. This compound has been shown to effectively induce the accumulation of ICMT in the cytoplasm of HCT-116 cells. Additionally, ICMT-IN-1 exhibits significant antiproliferative activity against various cancer cell lines that express K-Ras and N-Ras, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-30 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.27 μM. This compound is essential for studying the role of ICMT in various biological processes, including protein modification and signaling pathways. Its inhibition can be utilized in research focused on cancer, neurodegeneration, and other diseases associated with abnormal protein prenylation. -
ICMT Inhibitor
ICMT-IN-28 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 0.008 μM. This compound effectively disrupts the ICMT-mediated methylation of isoprenylated proteins, playing a critical role in cellular signaling pathways. ICMT-IN-28 is utilized in studies investigating the regulation of protein function and has potential applications in cancer research and other areas of cell biology. -
ICMT Inhibitor
ICMT-IN-52 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.052 μM. This compound plays a crucial role in research on post-translational modifications and protein maturation related to oncogenesis and cellular signaling. Its ability to effectively inhibit ICMT makes it a valuable tool for studying the biological implications of ICMT activity in various disease models. -
ICMT Inhibitor
ICMT-IN-5 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.3 μM. This compound modulates protein localization and activity through the inhibition of ICMT, making it valuable for studying signal transduction pathways and post-translational modifications. ICMT-IN-5 is suitable for research applications focused on cancer biology, neurobiology, and other fields where ICMT plays a critical role in regulating protein function. -
ICMT Inhibitor
ICMT-IN-34 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.17 μM. This compound exhibits significant biological activity in the modulation of protein methylation, influencing various cellular processes. It is valuable for research applications aimed at elucidating the roles of ICMT in signal transduction and cancer biology. -
ICMT Inhibitor
ICMT-IN-51 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.55 μM. This compound is essential for studying the role of ICMT in post-translational modifications of proteins, particularly in signaling pathways related to cancer and other diseases. Its utility in biochemical assays makes it a valuable tool for researchers investigating the therapeutic potential of ICMT modulation. -
ICMT Inhibitor
ICMT-IN-7 is a potent inhibitor of isoprenylcysteine methyltransferase (ICMT), with an IC50 of 0.015 μM. This compound effectively induces the accumulation of ICMT in the cytoplasm of HCT-116 cells and demonstrates significant inhibitory effects on the proliferation of various cancer cell lines that express K-Ras and N-Ras. ICMT-IN-7 is valuable for research applications targeting ICMT-related pathways in cancer biology. -
ICMT Inhibitor
ICMT-IN-6 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.09 μM. This compound effectively disrupts ICMT activity, which plays a critical role in protein prenylation processes. ICMT-IN-6 is valuable for studying the biological implications of ICMT inhibition and its potential therapeutic applications in cancer and other diseases involving dysregulated protein prenylation. -
ICMT Inhibitor
ICMT-IN-50 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.31 μM. This compound is utilized in research to investigate the role of ICMT in post-translational modifications and its impact on protein function and signaling pathways. Suitable for studies involving cancer biology and therapeutic development, ICMT-IN-50 provides a valuable tool for understanding ICMT's biological significance. -
ICMT Inhibitor
ICMT-IN-24 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.19 μM. This compound is utilized in research to explore the role of ICMT in post-translational modifications and its implications in various cellular processes. Its ability to inhibit ICMT makes it a valuable tool for studying protein activity and signaling pathways related to cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-15 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.032 μM. By blocking the activity of ICMT, this compound disrupts post-translational modifications of proteins involved in signaling pathways. ICMT-IN-15 is utilized in research focused on understanding the role of protein methylation in cellular processes and disease mechanisms, making it a valuable tool for studies in cancer, neurobiology, and other fields. -
ICMT Inhibitor
ICMT-IN-13 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.47 μM. This compound is crucial for studying the role of ICMT in post-translational modifications of proteins, particularly in oncogenic signaling pathways. Its application in chemical biology can provide insights into the regulation of protein function and potential therapeutic strategies targeting cancer progression. -
ICMT Inhibitor
ICMT-IN-46 is an inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.556 μM. This compound plays a critical role in modulating protein prenylation processes, impacting various signaling pathways. It is suitable for research applications focused on cellular signaling, protein modification, and the investigation of diseases where ICMT activity is a key factor. -
ICMT Inhibitor
ICMT-IN-37 is a selective inhibitor of Isoprenylcysteine methyltransferase (ICMT), exhibiting an IC50 of 0.308 μM. This compound is instrumental for investigating the role of ICMT in various cellular processes, including protein localization and signaling pathways. Its application extends to studies on post-translational modifications and the functional implications of ICMT inhibition in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-27 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.1 μM. This compound effectively disrupts the post-translational modification of proteins that rely on ICMT activity. It is primarily utilized in studies involving protein regulation, signal transduction, and cancer research, enabling scientists to explore the role of ICMT in various biological processes. -
ICMT Inhibitor
ICMT-IN-20 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.682 μM. This compound is instrumental in the study of post-translational modifications in proteins, facilitating research into their role in various cellular processes. ICMT-IN-20 is applicable in investigations of signal transduction pathways and may contribute to the understanding of certain diseases where ICMT activity is disrupted. -
ICMT Inhibitor
ICMT-IN-44 is a selective inhibitor of isopeptidase cyseel methyltransferase (ICMT) with an IC50 value of 0.167 μM. This compound is designed to disrupt the methylation of cyseel proteins, thereby influencing post-translational modifications and cellular signaling pathways. ICMT-IN-44 is valuable in biochemical research for studying the role of ICMT in various physiological and pathological processes, making it a useful tool in drug discovery and development. -
ICMT Inhibitor
ICMT-IN-36 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), showing an IC50 value of 0.181 μM. This compound is valuable for researchers investigating ICMT’s role in protein modification and its implications in cancer and other diseases. Its applications include studying protein stability and signaling pathways related to post-translational modifications. -
ICMT Inhibitor
ICMT-IN-12 is a selective inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT) with an IC50 value of 0.42 μM. This compound demonstrates important biological activity by blocking ICMT-mediated post-translational modifications, which play a crucial role in protein function and stability. ICMT-IN-12 is applicable in studies focusing on signaling pathways and cellular processes influenced by protein prenylation, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-8 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.652 μM. This compound is primarily utilized in research applications focusing on protein prenylation and related signaling pathways. Investigating ICMT's role can provide insights into its potential implications in cancer and other diseases linked to dysregulated protein modification. -
ICMT Inhibitor
ICMT-IN-21 is a potent inhibitor of isoprenylcysteine O-methyltransferase (ICMT), with an IC50 value of 8.8 μM. This compound features a sulfonamide-modified farnesyl cysteine structure, with key farnesyl and carboxylic acid motifs critical for its inhibitory activity. ICMT-IN-21 is valuable for investigating the role of ICMT in post-translational modifications and cellular signaling processes, providing insights into potential therapeutic interventions. -
ICMT Inhibitor
ICMT-IN-17 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.38 μM. This compound disrupts the methylation of isoprenylated proteins, which is crucial for their membrane localization and function. ICMT-IN-17 serves as a valuable tool in research aimed at understanding the role of protein methylation in various cellular processes and its implications in disease states. -
ICMT Inhibitor
ICMT-IN-26 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.36 μM. This compound is utilized in biochemical research to investigate the role of ICMT in protein modification and signal transduction pathways. Its inhibition profile makes it a valuable tool for studying diseases associated with dysregulated protein methylation. -
ICMT Inhibitor
ICMT-IN-16 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.131 μM. This compound is utilized in research to elucidate the role of ICMT in protein modification and signal transduction pathways. Its inhibition can provide insights into various cellular processes, making it a valuable tool for studies focused on cancer biology and other related fields. -
ICMT Inhibitor
ICMT-IN-41 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.069 μM. This compound has demonstrated significant potential in regulating post-translational modifications of proteins, making it valuable for studies related to cell signaling and protein stability. It is particularly relevant in research focused on cancer biology and the roles of protein modification in disease pathways. -
ICMT Inhibitor
ICMT-IN-31 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.0038 μM. This compound effectively disrupts protein farnesylation, influencing cellular processes such as signal transduction and protein localization. ICMT-IN-31 is particularly valuable for research in cancer biology and the study of post-translational modifications. -
ICMT Inhibitor
ICMT-IN-54 is an adamantyl analogue that functions as an inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 12.4 μM. This compound effectively inhibits the methylation of BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) in Saccharomyces cerevisiae expressing ICMT, thereby demonstrating its potential to interfere with ICMT-mediated methylation processes. ICMT-IN-54 is a valuable tool for research into the roles of ICMT in cellular signaling and protein modification. -
ICMT Inhibitor
ICMT-IN-18 is a potent inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT), demonstrating an IC50 of 0.066 μM. This compound is valuable for investigating the role of ICMT in post-translational modifications and protein processing. Its applications extend to studies of cancer biology and signal transduction pathways where altered protein function may influence disease progression. -
ICMT Inhibitor
ICMT-IN-40 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.031 μM. This compound disrupts protein modification by inhibiting cysteine methylation, a critical process for the function and stability of various proteins involved in cellular signaling. ICMT-IN-40 is useful in research applications focused on studying protein prenylation and its implications in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-11 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.031 μM. This compound is valuable for research into protein post-translational modifications and their implications in various cellular processes. It is particularly useful in studies focused on cancer biology and signaling pathways involving prenylated proteins. -
ICMT Inhibitor
ICMT-IN-29 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.019 μM. This compound exhibits significant inhibitory activity and can be utilized in research applications aimed at elucidating the role of ICMT in protein modification and cellular signaling pathways. Its ability to selectively inhibit ICMT makes it a valuable tool for studying the implications of isoprenylation in various biological contexts. -
ICMT Inhibitor
ICMT-IN-38 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.049 μM. This compound is valuable for investigating the role of ICMT in post-translational modifications and its implications in various biological processes. Research applications include studies on cancer biology and cellular signaling pathways, where modulation of ICMT activity may reveal novel therapeutic targets.
