Fig. 1 · Structure
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IWP-051
Soluble Guanylate Cyclase Agonist
IWP-051 is an agonist for soluble guanylate cyclase, with an EC50 of 290 nM. It effectively stimulates the production of cyclic guanosine monophosphate (cGMP) and shows a synergistic effect with nitric oxide (NO). This compound is suitable for research focusing on cardiovascular function, smooth muscle relaxation, and other cGMP-related signaling pathways. Moreover, IWP-051 demonstrates favorable pharmacokinetic properties in rat models, making it a valuable tool for in vivo studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 1354041-91-0 |
| Applications | Soluble Guanylate Cyclase Agonist |
| Formula | C17H11F2N5O2 |
| Molecular Weight | 355.30 |
| SMILES | O=C1NC(C2=NN(CC3=CC=CC=C3F)C(C4=NOC=C4)=C2)=NC=C1F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.