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S-3448

sGC Agonist

S-3448 is a soluble guanylate cyclase (sGC) agonist that selectively activates both the heme-containing and heme-deficient forms of sGC, independent of nitric oxide and heme. This compound demonstrates significant biological activity in modulating intracellular signaling pathways related to vasodilation and cardiovascular function. S-3448 is valuable for research applications focused on cardiovascular diseases, including arterial hypertension and pulmonary hypertension, providing insights into potential therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	254877-04-8
Applications	sGC Agonist
Formula	C₂₅H₂₆ClN₃O₇S₃
Molecular Weight	612.14
SMILES	O=C(NC1=CC=C(S(=O)(N2CCSCC2)=O)C=C1)C3=CC(OC)=C(OC)C=C3NS(=O)(C4=CC=C(Cl)C=C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.