Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
THP-PEG10-THP is a PEG-based PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, enabling the targeted degradation of specific proteins in cellular systems. THP-PEG10-THP is essential for researchers investigating protein regulation and therapeutic strategies for various diseases through targeted ubiquitination and proteasomal degradation. -
PROTAC Linkers
DSPE-PEG13-TFP ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of an E3 ligase recruiting module with a target protein ligand, promoting targeted protein degradation. Its application is crucial in advancing research focused on proteolysis and drug discovery, enabling the development of innovative therapeutic strategies. -
PROTAC Linker
Fluorescein-PEG3-NH-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances cellular permeability and stability, facilitating targeted degradation of specific proteins. It is primarily utilized in chemical biology research to study protein function and interactions through targeted protein degradation methods. -
PROTAC Linkers
Methyl acetate-PEG1-methyl acetate is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the formation of bifunctional molecules, enabling targeted protein degradation. Its unique structure enhances solubility and flexibility, making it suitable for diverse research applications in drug development and protein engineering. -
PROTAC Linker
OPSS-PEG8-COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the construction of bifunctional molecules that can selectively target and degrade proteins of interest via the ubiquitin-proteasome system. Its application is crucial for researchers investigating targeted protein degradation and developing novel therapeutic strategies in various diseases. -
PROTAC Linkers
Bromo-PEG1-NH2 hydrobromide is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound enables the targeted degradation of specific proteins by facilitating the assembly of E3 ligase complexes and the desired target proteins. It is a valuable tool in drug discovery and the development of novel therapeutic strategies focused on protein modulation. -
PROTAC linker
Biotin-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras). This compound facilitates the development of targeted protein degradation strategies, enabling the selective degradation of specific proteins within cells. Its biotinylated structure enhances the efficiency of target protein recruitment, making it a valuable tool for researchers investigating protein function and degradation pathways. -
PROTAC Linkers
DBCO-PEG1-NH-Boc is a PEG-based linkerso designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a dibenzocyclooctyne (DBCO) functional group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules. This reagent is integral in developing targeted protein degradation strategies, facilitating the specific modulation of protein levels in cellular studies. -
PROTAC Linkers
Decaethylene glycol dodecyl ether is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as a versatile scaffold for linking target proteins and E3 ligases, enhancing the selective degradation of specific proteins in cellular models. Its unique structure provides improved solubility and stability, making it an essential tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linkers
3,4-Dibromo-Mal-PEG4-Boc is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Its key mechanism involves facilitating the conjugation of target proteins to E3 ubiquitin ligases, thereby promoting targeted degradation. This compound is essential for researchers focusing on targeted protein degradation and related therapeutic development. -
PROTAC Linkers
N-(Azido-PEG3)-N-bis(PEG4-Boc) serves as a versatile PEG-based linker for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. Its azide group enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, while also facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is an effective tool in the design of targeted protein degradation strategies, promoting advancements in cellular and molecular biology research. -
PROTAC Linkers
Cbz-PEG5-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its structure facilitates the conjugation of target ligands to E3 ligase recruiters, enhancing the development of bifunctional compounds that promote targeted protein degradation. This reagent is essential for researchers focusing on the modulation of protein levels in various biological pathways. -
PROTAC Linker
5-(Biotinamido)pentylazide is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynes. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a valuable tool for chemical research in targeted protein degradation and related applications. -
PROTAC Linker
Mal-amido-PEG7-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its amide group facilitates the conjugation of partners targeting specific proteins for ubiquitin-mediated degradation. This linker enhances the solubility and biocompatibility of PROTAC compounds, making it valuable in drug discovery and therapeutic development targeting protein homeostasis. -
PROTAC Linkers
m-PEG3-OMs is a polyethylene glycol (PEG)-based linker specifically designed for the construction of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of E3 ligase-recruiting components to target proteins, enabling selective degradation through the ubiquitin-proteasome pathway. It is widely utilized in drug discovery and development research focused on targeted protein degradation. -
PROTAC Linker
Boc-NH-PEG7-Tos is a polyethylene glycol (PEG) based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This linker enhances the solubility and bioavailability of PROTAC compounds, improving their stability and efficacy in biological systems. It serves as a valuable tool for researchers exploring targeted protein degradation pathways and developing novel therapeutic strategies in drug discovery. -
PROTAC Linkers
Acid-C1-PEG5-Boc is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the construction of effective degraders by connecting a target protein ligand with an E3 ligase ligand, enhancing cellular proteolysis of target proteins. Its versatility makes it suitable for various applications in chemical biology and drug development, particularly in studies aimed at targeted protein degradation. -
PROTAC Linkers
m-PEG8-azide is a PEG-based linker specifically designed for PROTAC synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, m-PEG8-azide is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) when used with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for researchers engaged in targeted protein degradation studies. -
PROTAC Linkers
Tos-PEG4-CH2COOH is a PEG-derived linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its structural properties facilitate the formation of PROTACs that can effectively target specific proteins for selective degradation. This compound is integral to research applications focused on protein modulation and targeted protein degradation strategies in drug discovery and development. -
PROTAC Linker
Bis-PEG2-Boc is a polyethylene glycol-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the assembly of bifunctional molecules to promote targeted protein degradation, enabling the efficient study of protein function and regulation. This reagent is essential for researchers exploring innovative therapeutic approaches in drug discovery and development. -
PROTAC Linker
Bis-propargyl-PEG9 is a PEG-based linker designed for the synthesis of PROTACs, facilitating the development of targeted protein degradation strategies. This compound enables the construction of bivalent ligands, particularly for estrogen receptors, enhancing the efficacy of cellular target engagement. As a click chemistry reagent containing an alkyne group, Bis-propargyl-PEG9 is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Biotin-PEG6-Boc is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables the efficient conjugation of biotin to target proteins, facilitating selective degradation via the ubiquitin-proteasome pathway. Its application in PROTAC development supports research in targeted protein degradation and therapeutic intervention in various diseases. -
PROTAC Linker
5-[Boc(methyl)amino]pentanal is a bifunctional linker designed for use in the synthesis of PROTACs. This compound features an alkyl amine structure that facilitates robust target protein degradation through the ubiquitin-proteasome system. It is ideal for applications in chemical biology research focused on targeted protein modulation and therapeutic development. -
PROTAC Linker
NHS-PEG4-(m-PEG4)3-ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between targeting ligands and E3 ligase recruiters, enhancing the development of targeted protein degradation strategies. Its application is significant in chemical biology research, particularly in studies aimed at modulating protein levels within cells. -
PROTAC Linkers
Acid-PEG25-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by optimizing the conjugation of various protein tags and ligands. Its use is pivotal in research applications aimed at exploring novel therapeutic strategies through protein modulation and degradation pathways. -
PROTAC Linkers
m-PEG4-sulfonic acid functions as a PEG-based linker for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands and E3 ligases, enhancing the cellular delivery and degradation of specific protein targets. It is particularly valuable for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Azide-PEG3-C1-Ala is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatile linker is essential for studying targeted protein degradation and enhancing the efficacy of therapeutic agents. -
PROTAC Linker
Bis-PEG7-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that target specific proteins for degradation, thereby enabling the selective modulation of protein levels within cellular systems. Its unique structure enhances solubility and biocompatibility, making it suitable for various research applications in chemical biology and therapeutic development. -
PROTAC Linkers
Bis-Mal-PEG6 is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This bifunctional molecule facilitates the conjugation of ligands to E3 ligases, enabling targeted degradation of proteins within cells. Its application in PROTAC development supports research in areas such as targeted protein degradation and therapeutic development. -
PROTAC Linkers
MS-PEG12-THP is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the efficient conjugation of target proteins to E3 ubiquitin ligases, thereby enhancing the degradation of specific proteins in cellular contexts. Its applications include drug development and the study of targeted protein degradation mechanisms, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linkers
PEG4-MS is a polyethylene glycol (PEG) based linker designed specifically for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the formation of covalent bonds, enhancing the stability and solubility of the resultant PROTAC molecules. PEG4-MS plays a crucial role in targeted protein degradation studies and drug discovery research, aiding in the development of novel therapeutic agents. -
PROTAC Linkers
N-Boc-piperazine-C3-COOH is a chemical linker utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds, specifically designed for target protein degradation. This compound facilitates the assembly of bifunctional molecules that engage and ubiquitinate target proteins, promoting their degradation via the proteasome. Its application is significant in research focused on modulating immune checkpoints such as PD-1/PD-L1 through PROTAC PD-1/PD-L1 degrader-1 development. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononynes (BCN), making it a versatile tool for bioconjugation and targeted protein degradation studies. -
PROTAC linker
Boc-piperazine-C13-OTs is a versatile PROTAC linker designed for facilitating targeted protein degradation. This compound enables the construction of bifunctional molecules that can selectively degrade specific proteins, thereby offering significant potential in therapeutic applications. It is particularly useful in the synthesis of NC-R17 for various biochemical and cellular studies in the field of drug discovery and development. -
PROTAC Linkers
N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based linker designed for use in the synthesis of PROTAC (PROteolysis TArgeting Chimeras) molecules. This compound facilitates the conjugation of target proteins to E3 ligases, promoting the ubiquitination and degradation of specific proteins. Its application in research enhances the development of targeted protein degradation strategies in cellular studies and drug discovery. -
PROTAC Linker
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker featuring a terminal azide group. This unique compound enables the synthesis of PROTACs and serves as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups, making it a valuable tool for chemical biology research and therapeutic development. -
PROTAC Linker
Amino-PEG8-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism targets the recruitment of E3 ubiquitin ligases, facilitating the ubiquitination and degradation of specific proteins. This reagent is essential for developing novel therapeutic strategies aimed at modulating protein levels and has significant applications in chemical biology and drug discovery research. -
PROTAC Linkers
Tos-PEG2-CH2-Boc is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of molecular conjugates that can effectively engage specific target proteins for degradation via the ubiquitin-proteasome system. It is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies in drug discovery. -
PROTAC Linkers
Bis-PEG17-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation research. It is suitable for studies aiming to modulate specific protein levels within cellular systems, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linker
Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the formation of hybrid molecules capable of targeting specific proteins for degradation via the ubiquitin-proteasome pathway. Its structural attributes support enhanced solubility and bioavailability, making it suitable for various applications in chemical biology and therapeutic research. -
PROTAC Linker
Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC linker designed to facilitate targeted protein degradation by connecting EED-targeting ligands to E3 ligases. This compound enhances the efficacy of PROTACs by optimizing their pharmacokinetic profiles. Its structure enables effective dimerization of target proteins, making it useful in studies related to protein degradation pathways and drug discovery efforts in cancer and other diseases. -
PROTAC Linker
N-(Amino-PEG3)-N-bis(PEG3-acid) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of complex biomolecular constructs by providing a flexible and water-soluble connection, enhancing cellular permeability and targeting specificity. It is ideal for applications in drug discovery and development focused on targeted protein degradation. -
PROTAC Linker
S-Acetyl-PEG3-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and bioavailability of PROTAC molecules, facilitating targeted protein degradation in various biological contexts. Applications include drug discovery and development, where PROTACs are utilized to selectively degrade disease-associated proteins, thus offering potential therapeutic advantages in oncology and other therapeutic areas. -
PROTAC Linkers
Methyltetrazine-PEG5-triethoxysilane is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. It serves as a crucial component in the development of novel therapeutic strategies aimed at modulating protein expression and activity in various biological systems. -
PROTAC Linker
Cis-3-Aminocyclobutanecarboxylic acid serves as a PROTAC linker, enabling the construction of targeted protein degraders. Its unique structural properties facilitate the development of PROTACs that induce selective protein degradation, a promising approach in therapeutic research. This compound is essential for studies focused on targeted protein modulation and may enhance the efficacy of novel therapeutic strategies. -
PROTAC Linkers
m-PEG10-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates effective targeting and degradation of specific proteins within cellular environments. Its key biological activity enables the formation of functional PROTACs, making it a valuable tool for researchers investigating novel approaches to protein regulation and targeted therapies. -
PROTAC Linkers
Mal-PEG5-C2-NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules that can selectively target and degrade specific proteins via the ubiquitin-proteasome pathway. Its application in PROTAC development enables researchers to explore targeted protein degradation as a therapeutic strategy in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Amino-Tri-(m-PEG4-ethoxymethyl)-methane is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary role is to facilitate the effective linkage between target proteins and E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome system. This compound supports research applications in targeted protein degradation, offering a valuable tool for investigating therapeutic strategies in various diseases. -
PROTAC Linkers
Ald-Ph-PEG6-Boc is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the respective target proteins. Its unique structure aids in enhancing the solubility and bioavailability of PROTACs, making it a valuable tool for researchers investigating targeted protein degradation and related therapeutic strategies. -
PROTAC Linker
m-PEG8-C10-phosphonic acid is a PEG-based linker specifically designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by enhancing their solubility and binding properties. It plays a critical role in targeted protein degradation research applications, offering potential insights into therapeutic strategies for modulating protein levels within cells.
