Fig. 1 · Structure
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(S,R,S,R)-AHPC-Me
VHL Ligand
(S,R,S,R)-AHPC-Me is a ligand for the von Hippel-Lindau (VHL) protein, promoting its recruitment in cellular processes. This compound is valuable for research applications involving the regulation of hypoxia-inducible factors (HIFs) and the study of oxygen sensing pathways. Its unique properties enable researchers to explore the mechanisms of VHL-mediated ubiquitination and degradation of target proteins, contributing to a better understanding of various cancers and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2055344-67-5 |
| Applications | VHL Ligand |
| Formula | C23H32N4O3S |
| Molecular Weight | 444.59 |
| SMILES | CC(C)(C)[C@H](N)C(N1[C@@H](C[C@H](C1)O)C(N[C@@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.