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Form	MW
(S,R,S)-AHPC dihydrochloride This page	503.49
(S,R,S)-AHPC free base	430.567
(S,R,S)-AHPC hydrochloride	467.02

(S,R,S)-AHPC dihydrochloride

VHL Ligand

(S,R,S)-AHPC dihydrochloride is a VH032-based ligand that facilitates the recruitment of the von Hippel-Lindau (VHL) protein. This compound can be conjugated to various target proteins, such as BCR-ABL1, using a linker to create PROTACs like GMB-475. GMB-475 demonstrates significant biological activity by inducing degradation of BCR-ABL1, exhibiting an IC50 of 1.11 μM in Ba/F3 cells. This compound is valuable for research in targeted protein degradation and therapeutic development.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2137142-47-1
Applications	VHL Ligand
Formula	C₂₂H₃₂Cl₂N₄O₃S
Molecular Weight	503.49
Synonyms	VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride
SMILES	O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.